我们在2004-2013年期间对圣彼得堡9家医院的36例毛霉菌病患者进行了前瞻性观察。最常见的基础疾病是急性白血病（64％），主要危险因素是中性粒细胞减少(92%)和淋巴细胞减少(86%)。在50%的患者中，侵袭性曲霉病1-65天后诊断为毛霉菌病。毛霉菌病的主要临床形式是肺部（64％），而在50％的病例中发现了两个或两个以上的器官受累。毛霉菌病最常见的病因是根霉病。(48%)。12周生存率为50%。联合治疗（棘白菌素两性霉素B形式）和从潜在疾病中恢复可显着提高生存率。
We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004-2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1-65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve-week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
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