背景:口腔白斑(OLK)是一种常见的口腔潜在恶性疾病。仅OLK的全球患病率于2003年发表,而患病率在不同研究中有所不同。近年来,大规模的总结和定义相关的分析没有得到足够的重视。本研究旨在对口腔白斑的患病率研究进行系统评价,并评估其发生的诱发因素。
方法:在数据库(Pubmed,Embase,Scopus,和WebofScience)为1996年1月至2022年12月发表的OLK研究。估计的患病率计算和偏倚风险分析使用STATA16.0。
结果:我们获得了69项研究,包括1,263,028名参与者,来自28个国家,六大洲患病率为1.39%,从0.12到33.33%不等。在基于人群的研究中,OLK的总体汇总估计患病率为2.23%,1.36%用于以诊所为基础的人群研究,特定人群为9.10%。不同大洲的合并患病率为0.33%至11.74%,基于人群的计算具有统计学差异。男性OLK的估计患病率高于女性。那些吸烟和饮酒的人比那些不吸烟的人有更高的患病率。
结论:结合69项已发表研究的数据,OLK的患病率确定为1.39%,合并估计的全球患病率为3.41%.不同大陆和不同定义的患病率相对一致和稳定。在男性中发现了更高的汇总估计患病率,那些60岁以上的人,吸烟者,酒精消费者。本系统评价中纳入的研究结果表明,在不同的定义和大洲,患病率相对一致和稳定。这可能有助于制定口腔白斑的全球治疗和预防策略。
Oral leukoplakia(OLK) is a common oral potentially malignant disorder. The global prevalence of solely OLK was published in 2003, while the prevalence varied among different studies. In recent years, large-scale summary and definition-related analyses obtain insufficient attention. This study aimed to perform a systematic
review of prevalence studies of oral leukoplakia and assess predisposing factors of its occurrence.
The search terms (\"Oral leukoplakia\" OR OLK OR leukoplakia) AND (prevalence OR incidence OR epidemiology) were searched in databases (Pubmed, Embase, Scopus, and Web of Science) for OLK studies published from January 1996 until December 2022. The estimated prevalence calculation and risk of bias analysis used STATA 16.0.
We obtained 69 studies, including 1,263,028 participants, from 28 countries, and 6 continents. The prevalence was 1.39%, varying from 0.12 to 33.33%. The overall pooled estimated prevalence of OLK was 2.23% for population-based studies, 1.36% for clinic-based population studies, and 9.10% for specific populations. The pooled prevalence in different continents ranged from 0.33 to 11.74% with a statistical difference in the population-based calculation. The estimated prevalence of OLK was higher in males than in females. Those who smoked and consumed alcohol had a higher prevalence than those who did not.
Combining data from 69 published studies, the prevalence of OLK was determined as 1.39% and the pooling estimated global prevalence was 3.41%. The prevalence was relatively consistent and stable across different continents and different definitions. A higher pooled estimated prevalence was found among males, those aged over 60 years old, smokers, and alcohol consumers. The results from the included studies in this systematic
review revealed that the prevalence was relatively consistent and stable across various definitions and continents, which may help in developing global treatment and prevention strategies for oral leukoplakia.