利什曼病是一种被忽视的疾病,贫困,和复杂的疾病与日益严重的社会和公共卫生问题。总的来说,利什曼病是一种可治愈的疾病;然而,皮肤利什曼病(CL)治疗无反应病例的增加。CL治疗结果的有效和被忽视的决定因素之一是治疗依从性差(PTA)。PTA是利什曼原虫治疗的一个被忽视和普遍的现象。本研究旨在通过比较伊朗的常规统计方式和机器学习分析,探讨依从性差对无反应性治疗的影响。总的来说,190例,包括50名无反应患者(病例组),随机选择140例ACL缓解患者(对照组)。记录每种情况下包括25个查询(Q)的数据收集表,并通过R软件和遗传算法(GA)方法进行分析。复杂治疗方案(Q11),关于疾病和治疗的文化和观点(Q8),生活压力,绝望和负面情绪(Q22),治疗的不良反应(Q13),和长持续时间的病变(Q12)是最普遍的显著变量,抑制有效的治疗依从性的两种方法,按重要性递减顺序。在固有的算法方法中,类似于统计方法,最显著的特征是复杂的治疗方案(Q11).提供有关ACL的基本知识以及对慢性病患者和对化学药物有误解的患者的治疗是与疾病无反应直接相关的重要问题。此外,早期发现患者,以防止疾病的持续时间长和治疗过程,努力减少治疗的副作用,积极思考的诱导,医务人员给压力和焦虑的患者带来希望,和家人可以帮助患者坚持治疗。
Leishmaniasis is an overlooked, poverty-stricken, and complex disease with growing social and public health problems. In general, leishmaniasis is a curable disease; however, there is an expansion of unresponsive cases to treatment in cutaneous leishmaniasis (CL). One of the effective and ignored determinants in the treatment outcome of CL is poor treatment adherence (PTA). PTA is an overlooked and widespread phenomenon to proper Leishmania treatment. This study aimed to explore the effect of poor adherence in unresponsiveness to treatment in patients with anthroponotic CL (ACL) by comparing conventional statistical modalities and machine learning analyses in Iran. Overall, 190 cases consisting of 50 unresponsive patients (
case group), and 140 responsive patients (control group) with ACL were randomly selected. The data collecting form that included 25 queries (Q) was recorded for each
case and analyzed by R software and genetic algorithm (GA) approaches. Complex treatment regimens (Q11), cultural and lay views about the disease and therapy (Q8), life stress, hopelessness and negative feelings (Q22), adverse effects of treatment (Q13), and long duration of the lesion (Q12) were the most prevalent significant variables that inhibited effective treatment adherence by the two methods, in decreasing order of significance. In the inherent algorithm approach, similar to the statistical approach, the most significant feature was complex treatment regimens (Q11). Providing essential knowledge about ACL and treatment of patients with chronic diseases and patients with misconceptions about chemical drugs are important issues directly related to the disease\'s unresponsiveness. Furthermore, early detection of patients to prevent the long duration of the disease and the process of treatment, efforts to minimize side effects of treatment, induction of positive thinking, and giving hope to patients with stress and anxiety by medical staff, and family can help patients adhere to the treatment.