背景:掌叶大黄,R.tangutum,和R.officinale,大黄属的整体种,在全球温带和亚热带地区广泛使用。这些物种被纳入功能性食品中,药物,和化妆品,它们大量的生物活性成分。
目的:这篇综述旨在综合2014年至2023年有关植物学特征的发展,民族药理学,营养价值,化学成分,药理活性,行动机制,和这些物种的毒性。
方法:三种大黄的数据来自对同行评审文章的全面回顾,专利,以及通过PubMed获得的临床试验,谷歌学者,WebofScience,和CNKI。
结果:地上部分营养丰富,提供必需氨基酸,脂肪酸,矿物,适合用作保健食品或补充剂。研究已经确定了143种化合物,包括蒽醌,anthrones,黄酮类化合物,和色原,这有助于它们广泛的药理特性,如泻药,抗腹泻,神经保护,保肝,心血管,抗糖尿病药,抗肿瘤,抗炎,抗病毒,和抗菌作用。值得注意的是,通过评估不同治疗环境中的生物活性化合物,材料科学方法增强了对其药用能力的理解。
结论:作为具有药用和经济意义的草本植物,大黄物种提供可食用的地上部分和提供实质性健康益处的药用地下成分。这些特点为开发营养成分和治疗产品提供了新的机会,支持食品和制药行业。
BACKGROUND: Rheum palmatum, R. tanguticum, and R. officinale, integral species of the genus Rheum, are widely used across global temperate and subtropical regions. These species are incorporated in functional foods, medicines, and cosmetics, recognized for their substantial bioactive components.
OBJECTIVE: This
review aims to synthesize developments from 2014 to 2023 concerning the botanical characteristics, ethnopharmacology, nutritional values, chemical compositions, pharmacological activities, mechanisms of action, and toxicity of these species.
METHODS: Data on the three Rheum species were gathered from a comprehensive
review of peer-reviewed articles, patents, and clinical trials accessed through PubMed, Google Scholar, Web of Science, and CNKI.
RESULTS: The aerial parts are nutritionally rich, providing essential amino acids, fatty acids, and minerals, suitable for use as health foods or supplements. Studies have identified 143 chemical compounds, including anthraquinones, anthrones, flavonoids, and chromones, which contribute to their broad pharmacological properties such as
laxative, anti-diarrheal, neuroprotective, hepatoprotective, cardiovascular, antidiabetic, antitumor, anti-inflammatory, antiviral, and antibacterial effects. Notably, the materials science approach has enhanced understanding of their medicinal capabilities through the evaluation of bioactive compounds in different therapeutic contexts.
CONCLUSIONS: As medicinal and economically significant herb species, Rheum species provide both edible aerial parts and medicinal underground components that offer substantial health benefits. These characteristics present new opportunities for developing nutritional ingredients and therapeutic products, bolstering the food and pharmaceutical industries.