目的:评估在马罗匹坦和泮托拉唑的治疗方案中加入甲氧氯普胺是否会降低哮喘的发生率,胸腰段脊柱手术的短头犬呕吐和反流。
方法:随机盲法对照试验。
方法:共有43只短头犬接受胸腰段脊柱手术。
方法:除了标准化的麻醉方案,狗被随机分配给2mgkg-1day-1甲氧氯普胺恒定速率输注(CRI)或同等输注速率的盐水溶液,麻醉诱导后开始,气管拔管后5小时停止。呕吐的存在,反流和脓疱病,格拉斯哥综合疼痛量表疼痛评分的简短形式由失明的观察者每小时评估4小时,拔管后1小时开始。
结果:6只狗术后发生反流;安慰剂组3只狗,甲氧氯普胺组3只狗。术后返流的比值比(OR)在组间没有差异[OR:0.76,95%置信区间(CI):0.13-4.3,p=0.76]。术后3小时和4小时观察到ptypalism的几率约为术后1小时的15倍(OR均:15.4,95%CI:1.8-130.7,p=0.012),并且基于添加甲氧氯普胺(OR:0.73,95%CI:0.07-8.0,p=0.79)。观察疼痛的几率不随时间变化,并且基于添加甲氧氯普胺没有差异(OR:0.71,95%CI:0.12-4.2,p=0.71)。研究期间未发生呕吐(0.0%,95%CI:0.0-8.2%)。在研究期间,两组均未观察到不良反应。
结论:在马罗匹坦和泮托拉唑中添加甲氧氯普胺CRI并没有显著降低接受胸腰椎脊柱手术的短头犬的返流或返流。
OBJECTIVE: To assess whether adding metoclopramide to a protocol of maropitant and pantoprazole would reduce incidence of ptyalism, vomiting and regurgitation in brachycephalic dogs undergoing thoracolumbar spinal surgery.
METHODS: Randomized blinded controlled trial.
METHODS: A total of 43 brachycephalic dogs undergoing thoracolumbar spinal surgery.
METHODS: In addition to a standardized anaesthetic regimen, dogs were randomized to be administered either a 2 mg kg-1 day-1 metoclopramide constant rate infusion (CRI) or a saline solution at an equivalent infusion rate, started after anaesthetic induction and discontinued 5 hours after tracheal extubation. The presence of vomiting, regurgitation and pytalism, and short form of the Glasgow Composite Pain Scale pain scores were assessed by a blinded observer hourly for 4 hours, starting 1 hour postextubation.
RESULTS: Regurgitation occurred in six dogs postoperatively; three dogs were in the placebo group and three in the metoclopramide group. The odds ratio (OR) of regurgitation after surgery did not differ between groups [OR: 0.76, 95% confidence interval (CI): 0.13-4.3, p = 0.76]. The odds of observing ptyalism at 3 and 4 hours was approximately 15 times less than 1 hour postoperatively (both OR: 15.4, 95% CI: 1.8-130.7, p = 0.012) and did not differ based on the addition of metoclopramide (OR: 0.73, 95% CI: 0.07-8.0, p = 0.79). The odds of observing pain did not change over time and did not differ based on the addition of metoclopramide (OR: 0.71, 95% CI: 0.12-4.2, p = 0.71). Vomiting did not occur during the study (0.0%, 95% CI: 0.0-8.2%). No adverse effects were observed during the study period in either group.
CONCLUSIONS: The addition of a metoclopramide CRI to maropitant and pantoprazole did not result in a significant reduction in ptyalism or regurgitation in brachycephalic dogs undergoing thoracolumbar spinal surgery.