含大力水手结构域的蛋白3（POPDC3），具有独特的环磷酸腺苷（cAMP）结合位点的跨膜蛋白，在哺乳动物组织中广泛表达，在骨骼肌中表达水平最高。POPDC3在许多生理和病理过程中起着关键作用，被认为是癌症的候选生物标志物和潜在治疗靶标。此外,POPDC3基因变体与26型肢体带型肌营养不良（LGMD）有关。然而,关于POPDC3，相互作用蛋白的生物学作用的研究很少，潜在的下游目标，和调节信号通路。因此,本文综述了POPDC3蛋白的结构,相互作用的分子，以及在癌症中的作用和机制，在心肌和骨骼肌中，并对目前POPDC3的研究进展进行综述,提出未来可能的研究方向。本文受版权保护。保留所有权利。
The Popeye domain-containing protein 3 (POPDC3), a transmembrane protein with a unique cyclic adenosine monophosphate (cAMP) binding site, is widely expressed in mammalian tissues, with the highest levels of expression in skeletal muscle. POPDC3 plays a key role in many physiological and pathological processes and is considered a candidate biomarker and potential therapeutic target of cancer. In addition, POPDC3 gene variants have been associated with limb-girdle muscular dystrophy (
LGMD) type 26. However, there are only a few studies on the biological role of POPDC3, interacting proteins, potential downstream targets, and regulated signaling pathways. Therefore, this review focuses on the structure of POPDC3 protein, interacting molecules, and the role and mechanism in cancer, and in cardiac and skeletal muscle, and to review the current research progress of POPDC3 and propose possible future
study directions.
