(1)研究背景:曲霉菌产生高发病率和死亡率,尤其是在高危人群中。在西班牙,由于这种真菌,近年来死亡率的演变还没有得到很好的证实。这项研究的目的是估计1997年至2017年西班牙住院患者曲霉病的病死率。(2)方法:对纳入国家卫生系统诊断为曲霉病的住院患者的记录进行了回顾性描述性研究。(3)主要发现:在32,960例曲霉病住院患者中,24.5%的死亡登记,71%的死亡患者是男性。死亡百分比随着年龄的增长而逐渐增加。在此期间,病死率逐渐下降,从1997-1998年的25.4%和27.8%到2016年和2017年的20.6%和20.8%。流感和肺炎的发生/关联显着增加了所有病例的病死率。(4)结论:我们的研究表明,尽管病例有所增加,但在过去的二十年中,致死率显着下降。这突出了这样一个事实,即患有实体和/或血液系统癌症的患者的死亡率并不比单独患有肺炎或流感的患者组高得多,这两个因素是导致最高CFR的因素。我们还需要分析死亡率原因的研究来降低死亡率,以及评估COVID-19影响的研究。
(1) Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the
case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The
case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997-1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased
case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.