背景:白癜风的病因尚未完全阐明。最近,发现25-羟基维生素D(25(OH)D)和IL-33水平与白癜风的发展有关。目的是评估25(OH)D,IL-33水平,窄带UVB治疗白癜风的临床改善情况。
方法:本项研究包括接受至少48次窄带UVB治疗的白癜风患者。年龄,性别,吸烟状况,白癜风家族史,白癜风的类型,受白癜风影响的体表面积,记录白癜风活动。在基线测量和比较25(OH)D和IL-33,第二个月,第四个月。
结果:本研究包括20例白癜风患者和20例健康对照。白癜风组平均基线25(OH)D水平低于对照组(p<0.05)。白癜风组基线IL-33水平较高,差异无统计学意义(p>0.05)。在治疗期间,25(OH)D水平的增加和受白癜风影响的体表面积的减少具有统计学意义(p<0.05)。发现平均IL-33水平在第二个月和第四个月低于基线。然而,无统计学意义(p>.05)。
结论:低水平的25(OH)D被认为在白癜风的发病机制中起作用。光疗引起的25(OH)D增加可能在色素沉着中起作用,而与窄带UVB的直接作用无关。
BACKGROUND: The etiology of vitiligo has not been completely elucidated. Recently, 25-hydroxyvitamin D (25(OH)D) and IL-33 levels were found to be associated with the development of the vitiligo. The aim was to assess relationship between 25(OH)D, IL-33 levels, and clinical improvement after narrow-band UVB treatment in vitiligo.
METHODS: Patients with vitiligo who underwent at least 48 sessions of narrow-band UVB treatment were included in this study. Age, gender, smoking status, family history of vitiligo, type of vitiligo, body surface area affected by vitiligo, and vitiligo activity were recorded. 25(OH)D and IL-33 were measured and compared at baseline, second month, and fourth month.
RESULTS: Twenty patients with vitiligo and 20 healthy controls were included in this study. The mean baseline 25(OH)D level of vitiligo group was statistically significantly lower than the control group\'s (p < .05). The mean baseline IL-33 level was higher in vitiligo group with no statistically significantly difference (p > .05). The increase in 25(OH)D level and the decrease in vitiligo-affected body surface area were found to be statistically significant during treatment (p < .05). The mean IL-33 levels were found to be lower at the second and fourth month compared to baseline. However, there were no statistical significance (p > .05).
CONCLUSIONS: Low levels of 25(OH)D are thought to play a role in the etiopathogenesis of vitiligo. 25(OH)D increase due to phototherapy may have a role in repigmentation independently from the direct effect of narrow-band UVB.