■脓毒症是一种复杂的综合征,其特征是生理性,病态,和感染引起的生化异常。它的发展受到炎症等因素的影响,营养,和免疫状态。因此,我们联合C反应蛋白(CRP),白蛋白,和淋巴细胞,这可以反映上述状态,作为CRP-白蛋白-淋巴细胞(CALLY)指数,并探讨其与脓毒症危重患者临床预后的关系。
■这项回顾性观察性研究纳入了最初有CRP的脓毒症危重患者,白蛋白,和ICU入住第一天的淋巴细胞数据。所有数据均来自江苏大学附属医院。根据CALLY指数将患者分为四分位数(Q1-Q4)。结果包括30天/60天死亡率和急性肾损伤(AKI)发生。使用Cox比例风险和logistic回归分析评估了CALLY指数与脓毒症危重患者临床结局之间的关联。
■共有1,123名患者(63.0%男性)纳入研究。30天和60天死亡率分别为28.1%和33.4%,分别,而AKI的发生率为45.6%。Kaplan-Meier分析显示,较高的CALLY指数与较低的30天和60天死亡率风险之间存在显著关联(log-rankp<0.001)。多因素Cox比例风险分析显示CALLY指数与30天死亡率[HR(95CI):0.965(0.935-0.997);p=0.030]和60天死亡率[HR(95CI):0.969(0.941-0.997);p=0.032]独立相关。此外,多因素logistic回归模型显示,CALLY指数是AKI发生的独立危险预测因子[OR(95CI):0.982(0.962-0.998);p=0.033].
■这项研究的结果表明,CALLY指数与30天和60天死亡率之间存在显着关联,以及AKI的发生,在脓毒症危重患者中。这些研究结果表明,CALLY指数可能是一个有价值的工具,在确定败血症患者谁是在高风险的不利结果。
UNASSIGNED: Sepsis is a complex syndrome characterized by physiological, pathological, and biochemical abnormalities caused by infection. Its development is influenced by factors such as inflammation, nutrition, and
immune status. Therefore, we combined C-reactive protein (CRP), albumin, and lymphocyte, which could reflect above status, to be the CRP-albumin-lymphocyte (CALLY) index, and investigated its association with clinical prognosis of critically ill patients with sepsis.
UNASSIGNED: This retrospective observational
study enrolled critically ill patients with sepsis who had an initial CRP, albumin, and lymphocyte data on the first day of ICU admission. All data were obtained from the Affiliated Hospital of Jiangsu University. The patients were divided into quartiles (Q1-Q4) based on their CALLY index. The outcomes included 30-/60-day mortality and acute kidney injury (AKI) occurrence. The association between the CALLY index and these clinical outcomes in critically ill patients with sepsis was evaluated using Cox proportional hazards and logistic regression analysis.
UNASSIGNED: A total of 1,123 patients (63.0% male) were included in the
study. The 30-day and 60-day mortality rates were found to be 28.1 and 33.4%, respectively, while the incidence of AKI was 45.6%. Kaplan-Meier analysis revealed a significant association between higher CALLY index and lower risk of 30-day and 60-day mortality (log-rank p < 0.001). Multivariate Cox proportional hazards analysis indicated that the CALLY index was independently associated with 30-day mortality [HR (95%CI): 0.965 (0.935-0.997); p = 0.030] and 60-day mortality [HR (95%CI): 0.969 (0.941-0.997); p = 0.032]. Additionally, the multivariate logistic regression model showed that the CALLY index served as an independent risk predictor for AKI occurrence [OR (95%CI): 0.982 (0.962-0.998); p = 0.033].
UNASSIGNED: The findings of this
study indicated a significant association between the CALLY index and both 30-day and 60-day mortality, as well as the occurrence of AKI, in critically ill patients with sepsis. These findings suggested that the CALLY index may be a valuable tool in identifying sepsis patients who were at high risk for unfavorable outcomes.