■增生性疤痕是烧伤疤痕的常见和衰弱的后果。虽然目前治疗方案的证据有限，激光治疗已被证明是有效的，低风险和微创。这项研究评估了二氧化碳激光和强脉冲光设备在肥厚性烧伤疤痕治疗中的使用。
■在这种情况下，从增生性烧伤瘢痕等待名单中招募患者,并在激光治疗前和激光治疗后6周完成患者和观察者瘢痕评估量表.使用了CandelaMedical的Nordlys（强脉冲光）和CO2RE（二氧化碳）系统，根据烧伤疤痕的评估使用一系列的设置。计算患者和观察者疤痕评估量表总评分之间的差异，疼痛,痒,颜色,刚度,厚度,不规则性和疤痕的总体看法。使用配对完成统计分析，双尾学生T检验。
■这项试验共招募了31名患者，这些患者具有一系列的疤痕位置，烧伤的表面积和机制。计算的平均值差异显示患者和观察者疤痕评估量表总评分显著降低(1.93,p<0.0001),疼痛（1.39，p=0.0002），痒（1.84，p=0.0002），颜色（1.97，p<0.0001），刚度（2.47，p<0.0001），厚度（2.1，p<0.0001），不规则性(1.89，p<0.0001)和总体意见(1.58，p=0.0003)。
■目前对肥厚性瘢痕形成的治疗方案证据有限。激光治疗提供了一种微创手术，可以在局部麻醉下完成，并且在二氧化碳激光和强脉冲光设备联合治疗的单次治疗后显示出有效。
■许多人一生都会遭受烧伤，多达4个烧伤患者中的3个将遭受肥厚性疤痕（增厚，红色和发痒的疤痕)。这些疤痕由于其外观和功能降低而引起痛苦，特别是在关节或肌肉上。激光治疗,不同波长的光（脉冲光）或气体（二氧化碳）瞄准疤痕，已发现在肥厚性疤痕的管理中有效且副作用最小。虽然个别激光已被评估并发现是有效和低风险的，在同一疤痕上联合使用多个激光尚未得到广泛研究。我们研究了光和气体激光治疗对肥厚性疤痕的有效性。患有肥厚性疤痕的患者完成了一份问卷，该问卷侧重于他们对疤痕的看法（疼痛，痒,刚度,厚度,不规则，总体意见)在治疗前。然后使用脉冲光和/或二氧化碳（气体）激光对患者进行激光治疗（使用局部麻醉凝胶）。使用的激光类型由进行治疗的临床医生根据疤痕位置和厚度决定。然后，患者在激光治疗后六周重新完成主观调查，并对结果进行了比较。我们了解到激光治疗(两种光，气体和两者的组合）在减少患者疤痕的主观负担方面是有效的（且风险低）。
UNASSIGNED: Hypertrophic scarring is a common and debilitating consequence of burn scars. While there is limited evidence for current treatment options, laser therapy has been shown to be effective, low risk and minimally invasive. This study assesses the use of carbon dioxide lasers and intense pulsed light devices in the treatment of hypertrophic burn scars.
UNASSIGNED: In this
case series, patients were recruited from a hypertrophic burn scar waitlist and completed a Patient and Observer Scar Assessment Scale prior to and six weeks after laser therapy. The Nordlys (intense pulsed light) and CO2RE (carbon dioxide) systems from Candela Medical were used, with a range of settings used depending on the assessment of the burn scar. The differences between scores were calculated for the total Patient and Observer Scar Assessment Scale score, pain, itch, colour, stiffness, thickness, irregularity and the overall opinion of the scar. Statistical analysis was completed using a paired, two-tailed student T test.
UNASSIGNED: A total of 31 patients were recruited for this trial with a range of scar locations, surface areas and mechanism of burn injury. The calculated difference in mean showed a significant reduction for the overall Patient and Observer Scar Assessment Scale score (1.93, p < 0.0001), pain (1.39, p = 0.0002), itch (1.84, p = 0.0002), colour (1.97, p < 0.0001), stiffness (2.47, p < 0.0001), thickness (2.1, p < 0.0001), irregularity (1.89, p < 0.0001) and overall opinion (1.58, p = 0.0003).
UNASSIGNED: Current management options for hypertrophic scarring have limited evidence. Laser therapy presents a minimally invasive procedure that can be completed under topical anaesthetic and has shown to be effective following a single treatment of combined carbon dioxide laser and intense pulsed light device therapy.
UNASSIGNED: Many people will suffer a burn injury throughout their life and up to almost 3 out of 4 people with burn injuries will suffer from hypertrophic scars (a thickened, red and itchy scar). These scars cause distress both due to their appearance and their reduction of function, particularly over a joint or muscle. Laser therapy, in which different wave lengths of light (pulsed light) or gas (carbon dioxide) target the scar, has been found to be effective and have minimal side effects in the management of hypertrophic scars. While individual lasers have been assessed and found to be effective and low risk, the combined use of multiple lasers on the same scar has not been extensively studied. We studied the effectiveness of both light and gas laser therapies on hypertrophic scars. Patients with hypertrophic scars completed a questionnaire that focused on their perspective of their scar (pain, itch, stiffness, thickness, irregularity, overall opinion) prior to the treatment. The patients then underwent laser therapy (with local anaesthetic gel) with either pulsed light and/or carbon dioxide (gas) laser. The type of laser used was decided by the clinician performing the therapy depending on scar location and thickness. Patients then re-completed the subjective survey six weeks following the laser therapy, and the results compared. We learnt that laser therapy (both light, gas and a combination of both) are effective (and low risk) in reducing the subjective burden of the scar for the patient.
PDF(Pubmed)