目的:这项研究的目的是研究是否使用辅助Nd:YAG(1064nm)激光照射进行全口鳞屑和根部平整(FM-SRP)可以为患者的全身炎症状态提供额外的益处。如在单独FM-SRP的各种系统性生物标志物中所描绘的,治疗后12个月。
方法:将60例其他健康的III/IV期牙周患者平均分为3组。对照组接受FM-SRP。在激光A组中,FM-SRP后1周,Nd:YAG激光照射在PD≥4mm的牙周袋中使用特定设置(3W,150mJ,20Hz,100μs)。B组Nd:YAG激光照射两次,FM-SRP后1周和1周后,与激光A(2W,200mJ,10Hz,100μs)。
结果:激光A组在6个月时间点观察到IL-1β血清水平显着降低(p=0.038)。发现IL-6在6周时间点在对照组中显著增加(p=0.011),而激光治疗组没有差异(激光A,激光B)。
结论:Nd:YAG激光照射的辅助使用,FM-SRP后IL-6的增加被阻止,治疗后6周。同样,Nd:YAG激光辐照(3W,150mJ,20Hz,100μs)与显著降低的IL-1β水平相关,术后6个月。
结论:将Nd:YAG激光应用于FM-SRP可能对全身性炎症产生潜在的有益作用。
背景:ISRCTN26692900。
■09/06/2022。
OBJECTIVE: The aim of this
study was to investigate whether the use of adjunctive Nd:YAG (1064 nm) laser irradiation to full-mouth scaling and root planing (FM-SRP) may offer additional benefit in the systemic inflammatory status of the patient, as depicted in a variety of systemic biomarkers over FM-SRP alone, up to 12 months after treatment.
METHODS: A total of 60 otherwise healthy stage III/IV periodontal patients were equally distributed in 3 groups. The control group received FM-SRP. In laser A group, 1 week after FM-SRP, Nd:YAG laser irradiation was delivered in periodontal pockets with PD ≥ 4 mm using specific settings (3 W, 150 mJ, 20 Hz, 100 μs). In laser B group Nd:YAG laser irradiation was delivered twice, 1 week after FM-SRP and 1 week later with different settings compared to laser A (2 W, 200 mJ, 10 Hz, 100 μs).
RESULTS: A significant reduction (p = 0.038) of IL-1β serum levels at the 6-month time point was observed for laser A group. IL-6 was found statistically significantly increased (p = 0.011) in the control group at the 6-week time point, whereas no difference was reported for the laser-treated groups (laser A, laser B).
CONCLUSIONS: The adjunctive use of Nd:YAG laser irradiation, prevented from IL-6 increase after FM-SRP, 6 weeks after treatment. Similarly, Nd:YAG laser irradiation (3 W, 150 mJ, 20 Hz,100 μs) was associated with significantly lower IL-1β levels, 6 months post-operatively.
CONCLUSIONS: Additional Nd:YAG laser application to FM-SRP may provide a potential beneficial effect on systemic inflammation.
BACKGROUND: ISRCTN26692900.
UNASSIGNED: 09/06/2022.