PDF(Pubmed)
Abstract：
Community-acquired pneumonia (CAP) is a common respiratory disease in children. This prospective cohort study of 110 children with CAP and 100 healthy children investigated the relationship between the levels of vitamin A, D and E and inflammatory markers, such as tumour necrosis factor (TNF-a), interleukin-1 (IL-1), interleukin-10 (IL-10), neutrophils (NE) and C-reactive protein (CRP), in CAP. The haemoglobin, leukocyte concentration, NE, monocytes and CRP concentration in the CAP group showed significant differences (P < 0.05). The levels of vitamin A, D and E in the CAP group were lower than those in the control group, while the levels of TNF-a and IL-1 were higher than in the control group; the differences were statistically significant (P < 0.05). The IL-10 levels showed no significant differences (P > 0.05). Pearson analysis revealed that the vitamin A, D and E levels were all correlated with the TNF-a, IL-10 and CRP levels (P < 0.05). The vitamin A, D and E levels of the CAP children were lower than those of the healthy children. Thus, the content of fat-soluble vitamins is correlated with the secretion of TNF-a and IL-10. The research provides a new direction for the prevention, diagnosis and treatment of CAP.
摘要：
社区获得性肺炎(CAP)是儿童常见的呼吸道疾病。这项对110例CAP儿童和100例健康儿童进行的前瞻性队列研究调查了维生素A水平之间的关系。D和E和炎症标志物，如肿瘤坏死因子（TNF-a），白细胞介素-1（IL-1），白细胞介素-10（IL-10），中性粒细胞（NE）和C反应蛋白（CRP），在CAP。血红蛋白，白细胞浓度,NE,CAP组单核细胞和CRP浓度差异有统计学意义(P<0.05)。维生素A的水平，CAP组D、E均低于对照组,TNF-α、IL-1水平高于对照组,差异有统计学意义(P<0.05)。IL-10水平差异无统计学意义(P>0.05)。皮尔逊分析显示维生素A,D和E水平均与TNF-a相关,IL-10和CRP水平(P<0.05)。维生素A,CAP儿童的D和E水平低于健康儿童。因此，脂溶性维生素的含量与TNF-α和IL-10的分泌相关。该研究为预防疾病提供了新的方向,CAP的诊断和治疗。
