背景:氩气中毒是一个经常被忽视但严重的公共卫生问题,可能会导致严重和持续的神经系统后果。目前的治疗方案主要集中在急性期管理,但是对长期神经系统影响的全面了解仍然不完整。
方法:在氩气生产设施的炉房中发现一名22岁的男性工人失去知觉。恢复意识后,他出现头晕的症状,头痛,疲劳,和烦躁。神经系统检查显示近期记忆和远程记忆均受损,明显的短期记忆缺陷和算术技能下降。
方法:氩气中毒,缺氧性脑病,轻度肝肾功能障碍.
方法:入院时,对症支持措施包括经鼻插管氧疗(3升/分钟),每日高压氧治疗(1.5ATA,60分钟),口服神经营养甲钴胺(0.5毫克,每天3次),和静脉注射维生素C(每天2克)以清除氧自由基。
结果:为期2年的电话随访显示持续的短期记忆障碍,尤其是记住数字。在记忆测试中,他实现了向前5的数字跨度,但向后2的数字跨度,表明损伤。尽管面临这些挑战,他的日常生活和工作表现基本上没有受到影响。
结论:这个案例提供了关于窒息性气体暴露后神经后遗症延长的生物学机制的宝贵见解,特别是海马功能的持续性损伤。
BACKGROUND: Argon gas poisoning is an often overlooked yet critical public health concern with the potential for severe and persistent neurological consequences. Current treatment protocols primarily focus on acute-phase management, but a comprehensive understanding of the long-term neurological effects remains incomplete.
METHODS: A 22-year-old male worker was found unconscious in the furnace room of an argon production facility. After regaining consciousness, he presented with symptoms of dizziness, headache, fatigue, and irritability. Neurological examination revealed impairments in both recent and remote memory, notably pronounced short-term memory deficits and reduced arithmetic skills.
METHODS: Argon gas poisoning, hypoxic encephalopathy, and mild hepatic and renal dysfunction.
METHODS: Upon admission, symptomatic supportive measures included oxygen therapy via nasal cannula (3 L/min), daily hyperbaric oxygen therapy (1.5 ATA, 60 minutes), oral neurotrophic methylcobalamin (0.5 mg, 3 times daily), and intravenous vitamin C infusion (2 g daily) to scavenge oxygen free radicals.
RESULTS: A 2-year telephone follow-up indicated persistent short-term memory impairment, particularly with memorizing numbers. In a memory test, he achieved a digit span forward of 5 but a digit span backward of 2, indicating impairment. Despite these challenges, his daily life and work performance remained largely unaffected.
CONCLUSIONS: This
case offers valuable insights into the biological mechanisms underlying prolonged neurological sequelae following asphyxiating gas exposure, specifically the persistent impairment of hippocampal function.