原发性醛固酮增多症(PA)和阻塞性睡眠呼吸暂停(OSA)均被认为是高血压的独立危险因素。这可能导致心血管疾病发病率和死亡率的增加。临床研究发现OSA和PA之间存在双向关系。然而,它们之间的潜在机制尚不清楚。本研究旨在探讨PA和OSA的共同遗传特征和潜在的分子机制。我们从基因表达综合(GEO)数据库中获得了醛固酮产生腺瘤(APA)和OSA的微阵列数据集。加权基因共表达网络分析(WGCNA)用于选择与APA和OSA相关的共表达模块,两种疾病的共同基因是通过交叉获得的。随后,通过功能富集分析鉴定了APA和OSA的hub基因,蛋白质-蛋白质相互作用(PPI),数据集,和公共数据库。最后,我们预测了hub基因的转录因子(TFs)和miRNA。总的来说,通过WGCNA获得了52个常见基因。常见基因的基因本体论(GO)包括白细胞介素-1反应,细胞因子活性,和趋化因子受体结合。功能富集分析强调了TNF,IL-17信号,以及与APA和OSA相关的细胞因子-细胞因子受体相互作用。通过PPI,数据集,和公共数据库验证,我们鉴定了APA和OSA之间的5个hub基因(IL6,ATF3,PTGS2,CCL2和CXCL2).我们的研究确定了APA和OSA之间共有的5个hub基因(IL6,ATF3,PTGS2,CCL2和CXCL2)。通过生物信息学分析,我们发现这两种疾病在炎症方面表现出相对相似性,压力,免疫功能受损.hub基因的鉴定可能为PA和OSA的诊断和预后提供潜在的生物标志物。
Primary aldosteronism (PA) and obstructive sleep apnea (OSA) are both considered independent risk factors for hypertension, which can lead to an increase in cardiovascular disease incidence and mortality. Clinical studies have found a bidirectional relationship between OSA and PA. However, the underlying mechanism between them is not yet clear. This study aims to investigate the shared genetic characteristics and potential molecular mechanisms of PA and OSA. We obtained microarray datasets of aldosterone-producing adenoma (APA) and OSA from the gene expression omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was used to select co-expression modules associated with APA and OSA, and common genes of the two diseases were obtained by intersection. Subsequently, hub genes for APA and OSA were identified through functional enrichment analysis, protein-protein interaction (PPI), datasets, and public database. Finally, we predicted the transcription factors (TFs) and mirRNAs of the hub genes. In total, 52 common genes were obtained by WGCNA. The Gene Ontology (GO) of common genes includes interleukin-1 response, cytokine activity, and chemokine receptor binding. Functional enrichment analysis highlighted the TNF, IL-17 signaling, and cytokine-cytokine receptor interactions related to APA and OSA. Through PPI, datasets, and public databases verification, we identified 5 hub genes between APA and OSA (IL6, ATF3, PTGS2, CCL2, and CXCL2). Our study identified shared 5 hub genes between APA and OSA (IL6, ATF3, PTGS2, CCL2, and CXCL2). Through bioinformatics analysis, we found that the 2 disorders showed relative similarity in terms of inflammation, stress, and impaired immune function. The identification of hub genes may offer potential biomarkers for the diagnosis and prognosis of PA and OSA.