■一些观察性研究和临床实验表明,肠道微生物群与代谢疾病密切相关。然而,肠道微生物群对肾上腺疾病的因果关系,包括肾上腺皮质功能不全,库欣综合征,醛固酮增多症,仍然不清楚。
■本研究使用来自MiBioGen联盟进行的大规模全基因组关联研究的肠道微生物群的汇总统计数据进行了双样本孟德尔随机化分析。三种肾上腺疾病的汇总统计数据来自FinnGen研究。这项研究采用了方差反向加权,MR-Egger,和MR-PRESSO方法评估肠道微生物群与这三种肾上腺疾病之间的因果关系。此外,我们对孟德尔正向随机分析中发现与这3种肾上腺疾病有因果关系的细菌进行了反向孟德尔随机分析.Cochran的Q统计量用于检验工具变量的异质性。
■IVW测试结果表明,Deltaproteobacteria,脱硫弧菌科,和脱硫弧菌对肾上腺皮质功能不全具有保护作用。相反,卟啉科,幼虫属,和OrderMollicutesRF9与肾上腺皮质功能不全的风险增加相关。此外,酸性球菌科对库欣综合征具有一定程度的保护作用。相比之下,甲烷细菌类,家族乳杆菌科,甲烷杆菌科,属.乳杆菌和甲烷杆菌对醛固酮增多症具有保护作用。相反,Parasutterilla属,肽球菌属,和Veillonella属被确定为醛固酮增多症的危险因素。
■这项双样本孟德尔随机化分析揭示了诸如Deltoproteobacteria和Desulfovibrionaceae等微生物类群与肾上腺皮质功能不全之间的因果关系,库欣综合征,和醛固酮增多症。这些发现为理解由肠道微生物群介导的肾上腺疾病的发展提供了新的途径。
UNASSIGNED: Some observational studies and clinical experiments suggest a close association between gut microbiota and metabolic diseases. However, the causal effects of gut microbiota on adrenal diseases, including Adrenocortical insufficiency, Cushing syndrome, and Hyperaldosteronism, remain unclear.
UNASSIGNED: This
study conducted a two-sample Mendelian randomization analysis using summary statistics data of gut microbiota from a large-scale genome-wide association
study conducted by the MiBioGen Consortium. Summary statistics data for the three adrenal diseases were obtained from the FinnGen
study. The
study employed Inverse variance weighting, MR-Egger, and MR-PRESSO methods to assess the causal relationship between gut microbiota and these three adrenal diseases. Additionally, a reverse Mendelian randomization analysis was performed for bacteria found to have a causal relationship with these three adrenal diseases in the forward Mendelian randomization analysis. Cochran\'s Q statistic was used to test for heterogeneity of instrumental variables.
UNASSIGNED: The IVW test results demonstrate that class Deltaproteobacteria, Family Desulfovibrionaceae, and Order Desulfovibrionales exhibit protective effects against adrenocortical insufficiency. Conversely, Family Porphyromonadaceae, Genus Lachnoclostridium, and Order MollicutesRF9 are associated with an increased risk of adrenocortical insufficiency. Additionally, Family Acidaminococcaceae confers a certain level of protection against Cushing syndrome. In contrast, Class Methanobacteria, Family Lactobacillaceae, Family Methanobacteriaceae, Genus. Lactobacillus and Order Methanobacteriales are protective against
Hyperaldosteronism. Conversely, Genus Parasutterella, Genus Peptococcus, and Genus Veillonella are identified as risk factors for Hyperaldosteronism.
UNASSIGNED: This two-sample Mendelian randomization analysis revealed a causal relationship between microbial taxa such as Deltaproteobacteria and Desulfovibrionaceae and Adrenocortical insufficiency, Cushing syndrome, and Hyperaldosteronism. These findings offer new avenues for comprehending the development of adrenal diseases mediated by gut microbiota.