■脊柱受累是人类布鲁氏菌病的常见但严重的并发症。然而,关于布鲁氏菌病患者脊髓受累相关危险因素的信息有限.
■这项回顾性病例对照研究旨在确定与布鲁氏菌病住院患者脊柱并发症相关的潜在危险因素。
■在研究期间,在377名患者中诊断出布鲁氏菌病,其中108人(28.64%)出现脊髓受累。脊柱受累的患者明显比对照组的患者年龄大(平均年龄[标准差],53.25[10.48]对43.12[13.84]年,分别;P<.001)。脊柱受累患者的诊断延迟明显长于对照组(平均延迟[标准差],11.17[13.55]vs6.03[8.02]周;P=.001)。年龄>40岁(赔率比,5.42[95%置信区间,2.65-11.05];P<.001)和诊断延迟>4周(2.94[1.62-5.35];P<.001)与布鲁氏菌病的脊髓受累独立相关。L3-5水平的腰椎受影响最大(249中的152[61.04%])。两组之间的背痛(病例患者108中的92例与对照组108中的21例;P<.001)和脾肿大(分别为108中的23例与42例;P=.005)显着差异。
■年龄>40岁和诊断延迟>4周增加了布鲁氏菌病脊柱受累的风险。因此,从症状发作到诊断的时间应该缩短,采取有效措施降低脊柱受累风险。
UNASSIGNED: Spinal involvement is a common but serious complication of human brucellosis. However, information on the risk factors associated with spinal involvement in individuals with brucellosis is limited.
UNASSIGNED: This retrospective
case-control study aimed to determine the potential risk factors associated with spinal complications in inpatients with brucellosis.
UNASSIGNED: During the study period, brucellosis was diagnosed in 377 patients, of whom 108 (28.64%) showed spinal involvement. Those with spinal involvement were significantly older than patients in the control group (mean age [standard deviation], 53.25 [10.48] vs 43.12 [13.84] years, respectively; P < .001). The diagnostic delays were significantly longer in patients with spinal involvement than in the control group (mean delay [standard deviation], 11.17 [13.55] vs 6.03 [8.02] weeks; P = .001). Age >40 years (odds ratio, 5.42 [95% confidence interval, 2.65-11.05]; P < .001) and diagnostic delay >4 weeks (2.94 [1.62-5.35]; P < .001) were independently associated with spinal involvement in brucellosis. The lumbar spine at the L3-5 level was the most affected (152 of 249 [61.04%]). Back pain (92 of 108 in
case patients vs 21 of 108 in controls; P < .001) and splenomegaly (23 vs 42 of 108, respectively; P = .005) differed significantly between the 2 groups.
UNASSIGNED: Age >40 years and diagnostic delay >4 weeks increased the risk of spinal involvement in brucellosis. Therefore, the time from symptom onset to diagnosis should be shortened, using effective measures to reduce spinal involvement risk.