■探讨吸烟指数(以每天吸烟数量×吸烟年数计算)和慢性阻塞性肺疾病(COPD)持续时间对非小细胞肺癌(NSCLC)患者机会性胸部CT评估骨质疏松症(OP)的影响。
■共101例诊断为非小细胞肺癌的患者纳入我们的队列研究。其中,将50例有吸烟史和COPD病史的患者分配到实验组,而没有吸烟史和COPD史的51例患者被分配到对照组。通过常规胸部CT测量Hounsfield单位(HU)值,以研究骨密度。测量T4,T7,T10和L1椎体的中下部作为研究变量。
■性别差异不显著,年龄,身体质量指数,肺癌的类型,两组肺癌临床分期及合并症比较(P=0.938,P=0.158,P=0.722,P=0.596,P=0.813,P=0.655)。实验组T4、T7、T10、L1的总平均HU值分别为116.60±30.67、110.56±30.03、109.18(96.85~122.95),分别为94.63(85.20-104.12)和106.86±22.26,显著低于对照组(189.55±34.57,174.54±35.30,172.73(156.33-199.50),158.20(141.60~179.40)和177.50±33.49)(P<0.05)。在实验组中,吸烟指数和COPD病程与HU值呈显著负相关(r=-0.627,-0.542,P<0.05).
与对照组相比,有吸烟史和COPD病史的NSCLC患者表现出明显更低的HU值。此外,吸烟指数和COPD持续时间可能是影响NSCLC患者骨密度的影响因素。
UNASSIGNED: To investigate the effect of smoking index (calculated as number of cigarettes per day × smoking years) and chronic obstructive pulmonary disease (COPD) duration on osteoporosis (OP)evaluated by opportunistic chest CT in patients with non-small cell lung cancer (NSCLC).
UNASSIGNED: A total of 101 patients diagnosed with NSCLC were included in our cohort
study. Among them, 50 patients with a history of smoking and COPD were assigned to the experimental group, while 51 patients without a history of smoking and COPD were assigned to the control group. Hounsfield unit (HU) value was measured by conventional chest CT to investigate the bone mineral density; and the mean values of axial HU value in the upper, middle and lower parts of T4, T7, T10 and L1 vertebral bodies were measured as the
study variables.
UNASSIGNED: There were no significant differences in gender, age, body mass index, type of lung cancer, clinical stage of lung cancer and comorbidities between the two groups (P = 0.938,P = 0.158,P = 0.722,P = 0.596,P = 0.813,P = 0.655). The overall mean HU values of T4, T7, T10, L1 in the experimental group were 116.60 ± 30.67, 110.56 ± 30.03, 109.18 (96.85-122.95), 94.63 (85.20-104.12) and 106.86 ± 22.26, respectively, which were significantly lower than those in the control group (189.55 ± 34.57, 174.54 ± 35.30, 172.73 (156.33-199.50), 158.20 (141.60-179.40) and 177.50 ± 33.49) (P <0.05). And in the experimental group, smoking index and COPD duration were significantly and negatively correlated with HU values (r = -0.627, -0.542, P <0.05, respectively).
UNASSIGNED: Patients with NSCLC who have a history of smoking and COPD exhibit a notably lower HU value compared to the control groups. Additionally, it has been observed that the smoking index and duration of COPD may be influential factors affecting bone mineral density in NSCLC patients.