PDF(Pubmed)
Abstract：
UNASSIGNED: This study investigated the levels of bone morphogenetic protein 2 (BMP-2), osteocalcin, and 3D CT Hounsfield units following hyperbaric oxygen therapy (HBOT) in patients with cleft lip and palate (CLP) undergoing alveolar bone grafts to provide a pilot evaluation of the role of HBOT in osteogenesis.
UNASSIGNED: This prospective, quasi-experimental, pre-post-intervention study evaluated seven patients with CLP receiving HBOT after single-stage reconstructions with alveolar bone grafts. The outcomes included the serum levels of BMP-2 and osteocalcin and the 3D CT Hounsfield units obtained before and after the surgery, and after the five HBOT sessions, to a total of 12 measurements. The data were analyzed with linear mixed-effects models using the intervention stage (pre-surgery, pre-HBOT, first to fifth HBOT sessions) as covariates and adjusting for several baseline factors.
UNASSIGNED: A significant difference was found in outcome measures across time (ANOVA p < 0.001 for BMP-2 and osteocalcin, p = 0.01 for Hounsfield units), with mean values appearing to steadily increase once HBOT began. Regression analyses indicated that the effect of HBOT was evident in serum osteocalcin after the 1st HBOT session (adjusted b = 1.32; 95% CI 0.39, 2.25) and in serum BMP-2 after the third session (adjusted b = 6.61; 95% CI 1.93, 11.28). After the fifth session, the HBOT effect was fairly pronounced on the two outcomes: the adjusted increase compared to the baseline was 28.06 ng/mL for BMP-2 and 6.27 ng/mL for osteocalcin. Our mixed-effect models also showed a post-HBOT increase in Hounsfield units.
UNASSIGNED: We found an increase of BMP-2, osteocalcin, and Hounsfield units following the HBOT intervention. These may suggest an effect of HBOT on osteogenesis.
UNASSIGNED: This prospective, quasi-experimental, pre-post-intervention study evaluated seven patients with CLP receiving HBOT after single-stage reconstructions with alveolar bone grafts. The outcomes included the serum levels of BMP-2 and osteocalcin and the 3D CT Hounsfield units obtained before and after the surgery, and after the five HBOT sessions, to a total of 12 measurements. The data were analyzed with linear mixed-effects models using the intervention stage (pre-surgery, pre-HBOT, first to fifth HBOT sessions) as covariates and adjusting for several baseline factors.
UNASSIGNED: A significant difference was found in outcome measures across time (ANOVA p < 0.001 for BMP-2 and osteocalcin, p = 0.01 for Hounsfield units), with mean values appearing to steadily increase once HBOT began. Regression analyses indicated that the effect of HBOT was evident in serum osteocalcin after the 1st HBOT session (adjusted b = 1.32; 95% CI 0.39, 2.25) and in serum BMP-2 after the third session (adjusted b = 6.61; 95% CI 1.93, 11.28). After the fifth session, the HBOT effect was fairly pronounced on the two outcomes: the adjusted increase compared to the baseline was 28.06 ng/mL for BMP-2 and 6.27 ng/mL for osteocalcin. Our mixed-effect models also showed a post-HBOT increase in Hounsfield units.
UNASSIGNED: We found an increase of BMP-2, osteocalcin, and Hounsfield units following the HBOT intervention. These may suggest an effect of HBOT on osteogenesis.
摘要：
■这项研究调查了骨形态发生蛋白2（BMP-2）的水平，骨钙蛋白，唇腭裂（CLP）患者接受牙槽骨移植后高压氧治疗（HBOT）和3DCTHounsfield单位，以初步评估HBOT在成骨中的作用。
■这个前景，准实验,干预前后研究评估了7例CLP患者在单阶段重建牙槽骨移植后接受HBOT治疗.结果包括血清BMP-2和骨钙蛋白水平以及手术前后获得的3DCTHounsfield单位，在五次HBOT会议之后，共12次测量。使用干预阶段(手术前，HBOT之前，第一至第五次HBOT会议)作为协变量，并针对几个基线因素进行调整。
■在不同时间的结局指标中发现了显着差异（BMP-2和骨钙蛋白的ANOVAp<0.001，Hounsfield单位p=0.01)，一旦HBOT开始，平均值似乎稳步增加。回归分析表明，HBOT在第1次HBOT治疗后的血清骨钙蛋白（调整后的b=1.32；95％CI0.39，2.25）和第3次治疗后的血清BMP-2（调整后的b=6.61；95％CI1.93，11.28）中的作用明显。在第五届会议之后,两种结局的HBOT效应相当显著:与基线相比,BMP-2和骨钙蛋白的校正增加分别为28.06ng/mL和6.27ng/mL.我们的混合效应模型还显示了Hounsfield单位的HBOT后增加。
■我们发现BMP-2，骨钙蛋白，以及HBOT干预后的Hounsfield单位。这些可能表明HBOT对成骨的影响。
■这个前景，准实验,干预前后研究评估了7例CLP患者在单阶段重建牙槽骨移植后接受HBOT治疗.结果包括血清BMP-2和骨钙蛋白水平以及手术前后获得的3DCTHounsfield单位，在五次HBOT会议之后，共12次测量。使用干预阶段(手术前，HBOT之前，第一至第五次HBOT会议)作为协变量，并针对几个基线因素进行调整。
■在不同时间的结局指标中发现了显着差异（BMP-2和骨钙蛋白的ANOVAp<0.001，Hounsfield单位p=0.01)，一旦HBOT开始，平均值似乎稳步增加。回归分析表明，HBOT在第1次HBOT治疗后的血清骨钙蛋白（调整后的b=1.32；95％CI0.39，2.25）和第3次治疗后的血清BMP-2（调整后的b=6.61；95％CI1.93，11.28）中的作用明显。在第五届会议之后,两种结局的HBOT效应相当显著:与基线相比,BMP-2和骨钙蛋白的校正增加分别为28.06ng/mL和6.27ng/mL.我们的混合效应模型还显示了Hounsfield单位的HBOT后增加。
■我们发现BMP-2，骨钙蛋白，以及HBOT干预后的Hounsfield单位。这些可能表明HBOT对成骨的影响。
