目的：没有关于I类组蛋白脱乙酰酶（HDACs）的单核苷酸多态性（SNP）在2型糖尿病（DM）中的可能作用的数据。我们设计了这项研究来检查HDAC的多态性是否与该疾病有关。
方法：以社区为基础，进行了病例对照研究，共纳入568名受试者（284名患者和284名对照）。使用TaqMan技术检查了HDAC1（rs1741981）和HDAC3（rs11741808，rs2547547，rs2530223）的四个多态性。
结果：我们发现HDAC3的三个SNP与2型DM的风险显着相关，包括rs11741808[比值比（OR）=0.53，95％置信区间（CI）：0.35-0.81]，rs2547547[OR=1.72，95%CI：1.13-2.64]，和rs2530223[OR=1.39；95%CI：1.01-1.91]。亚组分析显示BMI≥23kg/m(2),高甘油三酯和高血压，与rs11741808AG基因型一起，与2型DM的风险显着降低相关，OR为0.50（95%CI：0.27-0.91），与AA基因型相比，0.38（95％CI：0.20-0.71）和0.43（95％CI：0.24-0.76），分别。在总胆固醇正常的人群中，AG基因型显著降低2型DM风险，与AA基因型的人相比，OR为0.42（95％CI：0.25-0.70）。对于rs2547547，在总胆固醇和甘油三酯正常的人群中，AG基因型与2型DM的风险显着增加有关，与携带AA基因型的人群相比，OR分别为1.92（95％CI：1.17-3.15）和2.24（95％CI：1.28-3.94）。
结论：结果表明，HDAC3的变异导致中国汉族人群中2型DM的患病率增加。
OBJECTIVE: There are no data regarding the possible role of the single nucleotide polymorphism (SNP) of class I histone deacetylases (HDACs) in type 2 diabetes mellitus (DM). We designed this study to examine whether polymorphisms of HDACs can be implicated in that disease.
METHODS: A community-based,
case-control study was conducted, with a total of 568 subjects (284 patients and 284 controls) enrolled. Four polymorphisms of HDAC1 (rs1741981) and HDAC3 (rs11741808, rs2547547, rs2530223) were examined by the use of TaqMan technology.
RESULTS: We found a significant association with risk of type 2 DM for three SNPs of HDAC3, including rs11741808 [odds ratio (OR)=0.53, 95% confidence interval (CI): 0.35-0.81], rs2547547 [OR=1.72, 95% CI: 1.13-2.64], and rs2530223 [OR=1.39; 95% CI: 1.01-1.91]. Subgroup analysis showed that BMI≥23kg/m(2), high triglyceride and high blood pressure, together with the rs11741808AG genotype, were associated with a significantly decreased risk for type 2 DM, with ORs of 0.50 (95% CI: 0.27-0.91), 0.38 (95% CI: 0.20-0.71) and 0.43 (95% CI: 0.24-0.76) compared with the AA genotype, respectively. In a population with normal total cholesterol, the AG genotype yielded a significantly decreased risk of type 2 DM risk, with an OR of 0.42 (95% CI: 0.25-0.70) when compared with the persons of the AA genotype. For rs2547547, in a population with normal total cholesterol and triglyceride, the AG genotype was associated with a significantly increased risk of type 2 DM, with ORs of 1.92 (95% CI: 1.17-3.15) and 2.24 (95% CI: 1.28-3.94) when compared with the population carrying the AA genotype.
CONCLUSIONS: The results suggest that variants of HDAC3 contribute to an increased prevalence of type 2 DM in the Chinese Han population.
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