{Reference Type}: Journal Article
{Title}: Three single nucleotide variants of the HDAC gene are associated with type 2 diabetes mellitus in a Chinese population: a community-based case-control study.
{Author}: Zeng Z;Liao R;Yao Z;Zhou W;Ye P;Zheng X;Li X;Huang Y;Chen S;Chen Q;
{Journal}: Gene
{Volume}: 533
{Issue}: 1
{Year}: Jan 2014 1
{Factor}: 3.913
{DOI}: 10.1016/j.gene.2013.09.123
{Abstract}: <B>OBJECTIVE: </B>There are no data regarding the possible role of the single nucleotide polymorphism (SNP) of class I histone deacetylases (HDACs) in type 2 diabetes mellitus (DM). We designed this study to examine whether polymorphisms of HDACs can be implicated in that disease.<BR><B>METHODS: </B>A community-based, case-control study was conducted, with a total of 568 subjects (284 patients and 284 controls) enrolled. Four polymorphisms of HDAC1 (rs1741981) and HDAC3 (rs11741808, rs2547547, rs2530223) were examined by the use of TaqMan technology.<BR><B>RESULTS: </B>We found a significant association with risk of type 2 DM for three SNPs of HDAC3, including rs11741808 [odds ratio (OR)=0.53, 95% confidence interval (CI): 0.35-0.81], rs2547547 [OR=1.72, 95% CI: 1.13-2.64], and rs2530223 [OR=1.39; 95% CI: 1.01-1.91]. Subgroup analysis showed that BMI≥23kg/m(2), high triglyceride and high blood pressure, together with the rs11741808AG genotype, were associated with a significantly decreased risk for type 2 DM, with ORs of 0.50 (95% CI: 0.27-0.91), 0.38 (95% CI: 0.20-0.71) and 0.43 (95% CI: 0.24-0.76) compared with the AA genotype, respectively. In a population with normal total cholesterol, the AG genotype yielded a significantly decreased risk of type 2 DM risk, with an OR of 0.42 (95% CI: 0.25-0.70) when compared with the persons of the AA genotype. For rs2547547, in a population with normal total cholesterol and triglyceride, the AG genotype was associated with a significantly increased risk of type 2 DM, with ORs of 1.92 (95% CI: 1.17-3.15) and 2.24 (95% CI: 1.28-3.94) when compared with the population carrying the AA genotype.<BR><B>CONCLUSIONS: </B>The results suggest that variants of HDAC3 contribute to an increased prevalence of type 2 DM in the Chinese Han population.