骨关节炎(OA)起因于遗传和环境因素的复杂相互作用。大量研究探讨了生长分化因子5(GDF-5)+104T>C多态性与OA风险的关系,但调查结果尚无定论。我们对704例OA病例和418例健康对照进行了病例对照研究。此外,我们通过彻底搜索9月1日之前发表的相关研究的文献进行了荟萃分析,2023年。组合比值比和95%置信区间用于评估相关性的强度。共有47项独立病例对照研究,包括17602例OA病例和30947例对照,进行了分析。其中,31项研究(11,176例,16,724个对照)专注于膝盖OA,8项研究(3,973例,8,055个对照)检查了髋关节OA,和6项研究(2244例,5965个对照)调查了手部OA。总的来说,我们的发现表明,GDF-5104T>C多态性在全球范围内对OA的发展具有保护作用。按种族划分的亚组分析表明,这种遗传变异为高加索人提供了对OA的保护,亚洲人,和非洲人口。基于OA类型的进一步亚组分析显示,与这种变异相关的膝关节和手OA的风险降低,但不适用于髋关节OA。我们的综合数据表明,GDF-5+104T>C多态性提供了对OA发展的保护,以及膝盖和手OA。然而,该多态性与髋关节OA的发生无相关性。
Osteoarthritis (OA) arises from a intricate interplay of genetic and environmental factors. Numerous studies have explored the link between the growth differentiation factor 5 (GDF-5) +104T>C polymorphism and OA risk, but the findings have been inconclusive. We carried out a
case-control study with 704 OA cases and 418 healthy controls. Furthermore, we conducted a meta-analysis by thoroughly searching the literature for relevant studies published until 1 September, 2023. The combined odds ratio and 95% confidence intervals were used to assess the correlation\'s strength. A total of 47 independent
case-control studies, including 17,602 OA cases and 30,947 controls, were analyzed. Of these, 31 studies (11,176 cases, 16,724 controls) focused on knee OA, 8 studies (3,973 cases, 8,055 controls) examined
hip OA, and 6 studies (2244 cases, 5965 controls) investigated hand OA. Overall, our findings suggest that the GDF-5 + 104T>C polymorphism has a protectibe role in development of OA in global scale. Subgroup analyses by ethnicity indicated that this genetic variation provides protection against OA in Caucasian, Asian, and African populations. Further subgroup analysis based on the type of OA showed a decreased risk of knee and hand OA associated with this variation, but not for
hip OA. Our combined data indicates that the GDF-5 + 104T>C polymorphism offers protection against the development of OA in general, as well as knee and hand OA. Nevertheless, there was no correlation found between this polymorphism and the development of
hip OA.