■在韦斯利公会医院(WGH)比较稳态镰状细胞性贫血(SCA)患者与血管闭塞性危象(VOC)患者的心血管特征。
■描述性横截面,匹配,WGHSCA儿童的病例对照研究,尼日利亚西南部的三级医疗机构。
■参与者从WGH的儿童急诊室和儿科血液学诊所招募。
■由93名患有VOC的儿童(病例)和93名处于稳定状态的年龄和性别匹配的儿童(对照)组成,5-15岁。
■心血管参数,包括脉搏率,血压,和心电图轮廓,使用适当的统计检验进行评估和比较。
■病例和对照组的平均(SD)年龄分别为8.8(3.2)岁和9.0(3.1)岁,分别(p=0.106)。各组的平均身高没有显着差异。平均脉搏率,舒张压,收缩压,病例的平均动脉压明显高于对照组。与对照组相比,明显较高比例的病例发生心脏传导阻滞的频率也较高,QTc间期延长,ST段抬高或凹陷,和T波异常(p分别为0.018、0.039、0.041、0.009)。两组之间的腔室扩大发生率没有显着差异。
■与稳态相比,VOC期间的心血管功能障碍更为严重。医生应该在患有VOC的SCA儿童中寻找这些功能障碍,以降低该疾病的死亡率。
■没有声明。
UNASSIGNED: To compare the cardiovascular features of patients with sickle cell anaemia (SCA) in steady-state with those in vaso-occlusive crisis (VOC) at the Wesley Guild Hospital (WGH).
UNASSIGNED: A descriptive cross-sectional, matched, case-control study among children with SCA at the WGH, a tertiary health facility in southwest Nigeria.
UNASSIGNED: The participants were recruited from the children\'s emergency unit and paediatric haematology clinic of the WGH.
UNASSIGNED: Consisted of 93 children with VOC (cases) and 93 age and sex-matched in steady state (controls), aged 5 - 15 years.
UNASSIGNED: Cardiovascular parameters, including pulse rate, blood pressure, and electrocardiographic profile, were assessed and compared using the appropriate statistical tests.
UNASSIGNED: The mean (SD) age of the cases and controls were 8.8 (3.2) years and 9.0 (3.1) years, respectively (p= 0.106). There was no significant difference in the mean height of the groups. The mean pulse rate, diastolic, systolic, and mean arterial pressures were significantly higher in the cases than in the controls. A significantly higher proportion of the cases than the controls also had a higher frequency of heart blocks, prolonged QTc interval, ST elevation or depression, and T wave abnormality (p = 0.018, 0.039, 0.041, 0.009, respectively). The prevalence of chamber enlargements was not significantly different between the two groups.
UNASSIGNED: Cardiovascular dysfunction is worse during VOC when compared with steady state. Physicians should look for these dysfunctions in SCA children with VOC to reduce mortality from the disease.
UNASSIGNED: None declared.