■作者旨在进行荟萃分析,以评估单纯疱疹病毒(HSV)感染与患痴呆症风险之间的关联。
■作者搜索了以下数据库:PubMed,Scopus,科克伦图书馆,和WebofScience。作者纳入了任何随机对照试验和对照观察研究,调查了HSV感染患者和无HSV对照组的痴呆患病率。此外,如果研究测量了痴呆患者与健康对照组的HSV抗体水平和这些抗体的发生率。
■经过全面的文献检索,19项研究纳入荟萃分析,342.535名患者纳入分析。汇总分析显示,阿尔茨海默病(AD)、轻度认知障碍(MCI),和IgG滴度水平升高组[平均差异(MD)=0.99,95%置信区间(CI)=0.36-1.63,P值=0.002],(MD=0.80,95%CI=0.26-1.35,P值=0.004),分别。此外,一般逆方差显示,与无HSV对照组相比,HSV组痴呆发病率增加具有统计学意义[风险比(RR)=2.23,95%CI=1.18~2.29,P值<0.00001].此外,该分析显示AD组和对照组在抗HSVIgM滴度n(%)结局方面无统计学意义(RR=1.35,95%CI=0.91-2.01,P值=0.14),分别。
■这项研究表明,AD和MCI患者针对HSV感染的IgG抗体滴度水平升高。该研究表明,HSV感染与痴呆症发病率增加之间存在显着关联。因此,定期随访HSV患者的IgG滴度水平可能有助于预防这些患者的痴呆.
UNASSIGNED: The authors aimed to perform a meta-analysis to evaluate the association between herpes simplex virus (
HSV) infection and the risk of developing dementia.
UNASSIGNED: The authors searched the following databases: PubMed, Scopus, Cochrane Library, and Web of Science. The authors included any randomized control trials and controlled observational studies that investigated the prevalence of dementia in HSV-infected patients and
HSV-free control group. Also, if the studies measured the levels of
HSV antibodies and incidence of these antibodies in patients with dementia compared with a healthy control group.
UNASSIGNED: After a comprehensive literature search, 19 studies were included in the meta-analysis with 342 535 patients included in the analysis. The pooled analysis showed a statistically significant association between Alzheimer\'s disease (AD), mild cognitive impairment (MCI), and increased levels of IgG titer group [mean difference (MD) = 0.99, 95% confidence interval (CI) = 0.36-1.63, P-value = 0.002], (MD = 0.80, 95% CI = 0.26-1.35, P-value = 0.004), respectively. Additionally, the generic inverse variance showed a statistically significant association between the HSV group and increased incidence of dementia compared with the no
HSV control group [risk ratio (RR) = 2.23, 95% CI = 1.18-2.29, P-value <0.00001]. Moreover, this analysis showed no statistically significant difference between the AD group and the control group in anti-HSV IgM titer n (%) outcome (RR = 1.35, 95% CI = 0.91-2.01, P-value = 0.14), respectively.
UNASSIGNED: This study revealed that AD and MCI patients have increased levels of IgG antibodies titer against HSV infection. The study showed a significant association between
HSV infection and increased incidence of dementia. Thus, regular follow-up of HSV patients\' IgG titer levels could be useful in the prevention of dementia in these patients.