未经证实:评估诊断为弓形虫病的孕妇(PW)的炎症和调节血浆介质的可用信息。来源:PubMed,Embase,Scopus,和紫丁香数据库的评估一直持续到2022年10月。研究资格标准:这项审查是在PRISMA之后进行的,并在PROSPERO平台(CRD42020203951)上注册。考虑了报道弓形虫病PW中炎症介质的研究。
未经批准:排除重复文章后,两位作者独立进行了标题和摘要排除的过程,第三,必要时解决分歧。对全文进行了评价检测相关文章。提取表是根据以下数据构建的:作者,出版年份,期刊名称和影响因素,国家,研究设计,妊娠数和产妇年龄(岁),妊娠期,弓形虫病的诊断,炎症标志物的水平,实验室测试,和临床意义。使用JoannaBriggs研究所工具评估方法学质量。
未经批准:在报告的1,024项研究中,只有八个人被包括在内。在本次审查中包括的868个PW中,弓形虫的IgM+/IgG-为20.2%,IgG-/IgG+为50.8%,29.0%未感染。感染的PW呈现较高的血浆IL-5、IL-6、IL-8、IL-17、CCL5和IL-10水平。关于方法学质量,四项研究获得了高质量。这篇综述的数据指出,怀孕期间炎症模式的维持与寄生虫密切相关。
未经证实:PW中的免疫状态定义了弓形虫感染的过程,其中炎症和调节细胞因子之间的平衡减轻了有害的胎盘和胎儿的影响。
UNASSIGNED:https://www。crd.约克。AC.英国/普华永道/,标识符CRD420203951。
To evaluate the available information on inflammatory and regulatory plasma mediators in pregnant women (PW) diagnosed with toxoplasmosis. Source: The PubMed, Embase, Scopus, and Lilacs databases were evaluated until October 2022. Study eligibility criteria: This
review was carried out following the PRISMA and registered on the PROSPERO platform (CRD42020203951). Studies that reported inflammatory mediators in PW with toxoplasmosis were considered.
After excluding duplicate articles, two authors independently carried out the process of title and abstract exclusion, and a third resolved disagreements when necessary. The full text was evaluated to detect related articles. The extraction table was built from the following data: Author, year of publication, journal name and impact factors, country, study design, number of gestations and maternal age (years), gestational period, diagnosis of toxoplasmosis, levels of inflammatory markers, laboratory tests, and clinical significance. Methodological quality was assessed using Joanna Briggs Institute tools.
Of the 1,024 studies reported, only eight were included. Of the 868 PW included in this
review, 20.2% were IgM+/IgG- and 50.8% were IgM-/IgG+ to T. gondii, and 29.0% uninfected. Infected PW presented higher plasma levels ofIL-5, IL-6, IL-8, IL-17, CCL5, and IL-10. Regarding the methodological quality, four studies obtained high quality. Data from this
review pointed out the maintenance of the inflammatory pattern during pregnancy with a closely related to the parasite.
Immune status in PW defined the course of the T. gondii infection, where the equilibrium between inflammatory and regulatory cytokines mitigated the harmful placenta and fetus effects.
https://www.crd.york.ac.uk/prospero/, identifier CRD420203951.