■外部根尖根吸收(EARR)的特征是牙根根尖处的牙齿结构永久丧失。本研究旨在系统评价与正畸患者EARR相关的基因多态性。
■在多个数据库中进行电子数据库搜索。
■这项系统评价包括21项研究。结果测量基于治疗前后获得的X射线照片上观察到的牙齿尺寸。使用聚合酶链反应限制性片段长度多态性分析对以下基因的多态性进行基因分型:嘌呤能受体P2X,配体门控离子通道7(P2RX7),胱天蛋白酶-1/白细胞介素转换酶(CASP1/ICE),caspase-5(CASP5),IL-1β(IL1B),IL-1α(IL1A),白细胞介素-1受体拮抗剂基因(IL1RN),组织非特异性碱性磷酸酶(TNSALP),肿瘤坏死因子-α(TNFα),肿瘤坏死因子受体超家族基因成员11a(TNFRSF11A),分泌磷蛋白1(SPP1),肿瘤坏死因子受体超家族基因成员11b(TNFRSF11B),白细胞介素17A(IL17),白细胞介素6(IL6),核因子-κB受体活化因子(RANK),骨保护素(OPG),基质抗原2(STAG2),维生素D受体(VDR),细胞色素P450家族24亚家族A成员1(CYP24A1),细胞色素P450家族27亚家族B(CYP27B1),组特定成分(GC),和白细胞介素-1受体相关激酶1(IRAK1)。
■几乎所有研究都表明IL1基因与EARR相关。此外,P2RX7可能是导致EARR发病的重要因素。TNFRSF11A,SPP1,IL1RN,IL6,TNFRSF11B,STAG2,VDR,IRAK1,IL-17,CASP1/ICE和CASP5已在分离的研究中鉴定。需要进一步的观察研究来更好地解释这些基因与EARR之间的关联。
UNASSIGNED: External apical root resorption (EARR) is characterized by permanent loss of dental structure at the root apex. This study aimed to systematically review gene polymorphisms associated with EARR in orthodontic patients.
UNASSIGNED: Electronic database searches were performed across several databases.
UNASSIGNED: This systematic review included 21 studies. Outcome measures were based on tooth dimensions observed on radiographs obtained before and after treatment. Polymorphisms in the following genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis: purinergic-receptor-P2X, ligand-gated ion channel 7 (P2RX7), caspase-1/interleukin-converting enzyme (CASP1/ICE), caspase-5 (CASP5), IL-1beta (IL1B), IL-1alpha (IL1A), interleukin-1 receptor antagonist gene (IL1RN), tissue non-specific alkaline phosphatase (TNSALP), tumor necrosis factor-alpha (TNFα), tumor necrosis factor receptor superfamily gene member 11a (TNFRSF11A), secreted phosphoprotein 1 (SPP1), tumor necrosis factor receptor superfamily gene member 11b (TNFRSF11B), interleukin 17A (IL17), interleukin 6 (IL6), receptor activator of nuclear factor-kappa B (RANK), osteoprotegerin (OPG), stromal antigen 2 (STAG2), vitamin D receptor (VDR), cytochrome P450 family 24 subfamily A member 1 (CYP24A1), cytochrome P450 family 27 subfamily B (CYP27B1), group-specific component (GC), and interleukin-1 receptor-associated kinases 1 (IRAK1).
UNASSIGNED: Almost all studies suggested that IL1 gene is associated with EARR. Additionally, P2RX7 may be an important factor contributing to the etiopathogenesis of EARR. TNFRSF11A, SPP1, IL1RN, IL6, TNFRSF11B, STAG2, VDR, IRAK1, IL-17, CASP1/ICE and CASP5 have been identified in isolated studies. Further observational studies are needed to better explain the association between these genes and EARR.