背景:在新的多囊卵巢综合征(PCOS)国际指南的背景下,研究雄激素受体(AR)的CAG重复多态性是否与腔卵泡计数(AFC)≥20的多囊卵巢形态(PCOM)的风险有关。
方法:收集109例PCOS患者和61例对照者的血液,通过测序测量ARCAG重复长度。观察CAG重复长度的平均数和频率分布。通过将PCOS病例分为低AFC组(L-AFC,AFC<20)和高AFC组(H-AFC,AFC≥20)根据新的国际循证指南。
结果:H-AFC组中具有较低CAG重复序列长度的个体的部分明显大于具有较高CAG重复序列长度的个体。Logistic模型显示,CAG长度较低的个体倾向于发展H-AFC。
结论:PCOS患者AR基因中CAG重复序列长度较低增加PCOM的风险。
BACKGROUND: To study whether CAG repeat polymorphism of androgen receptor (AR) contributes to the risk of polycystic ovarian morphology (PCOM) with antral follicle count (AFC) ≥ 20 in the context of new international
guideline of polycystic ovary syndrome (PCOS).
METHODS: Blood of 109 PCOS cases and 61 controls were collected for the measurement of AR CAG repeats length by sequencing. The mean number and frequency distribution of CAG repeats length were observed. Detailed analysis was conducted by dividing PCOS cases into low AFC group (L-AFC, AFC < 20) and high AFC group (H-AFC, AFC ≥ 20) according to the new international evidence-based
guideline.
RESULTS: The portion of individuals with lower CAG repeats length in H-AFC group was significantly larger than those with higher CAG repeats length. Logistic model revealed individuals with lower CAG length tended to develop H-AFC.
CONCLUSIONS: Lower CAG repeats length in the AR gene of PCOS cases increases risk of PCOM.