目的:恒牙牙根吸收是一种常见的病理过程,常伴随着牙外伤或正畸治疗。很少,牙根吸收是遗传性疾病的一个特征,可以帮助诊断。因此,本综述旨在确定哪些遗传疾病可以引起病理性牙根吸收,从而确定哪些突变基因可能与之相关。
方法:我们遵循PRISMA指南进行了系统评价。来自PubMed的文章描述了遗传性疾病患者的牙根吸收,Embase,WebofScience,谷歌学者。我们合成了遗传疾病,类型,严重程度,以及吸收的程度,以及其他全身和口腔症状和组织学特征。
结果:综合分析包括937项确定记录中的25项研究。我们分析了21例病例报告,三个案例系列,和一项队列研究。总的来说,我们强调了14种不同的病理与描述的牙根吸收。根据病理学,吸收的部位,他们的程度,和他们的严重程度显示出差异。
结论:怀疑有14种遗传病导致牙根吸收,我们的发现意义重大,丰富了以往的分类.其中,三种代谢紊乱,三种钙磷代谢紊乱,并确定了骨溶解障碍。
OBJECTIVE: Root resorption in permanent teeth is a common pathological process that often follows dental trauma or orthodontic treatment. More rarely, root resorption is a feature of genetic disorders and can help with diagnosis. Thus, the present
review aims to determine which genetic disorders could induce pathological root resorptions and thus which mutated genes could be associated with them.
METHODS: We conducted a systematic
review following the PRISMA guidelines. Articles describing root resorptions in patients with genetic disorders were included from PubMed, Embase, Web of Science, and Google Scholar. We synthesized the genetic disorder, the type, severity, and extent of the resorptions, as well as the other systemic and oral symptoms and histological features.
RESULTS: The synthetic analysis included 25 studies among 937 identified records. We analyzed 21 case reports, three case series, and one cohort study. Overall, we highlighted 14 different pathologies with described root resorptions. Depending on the pathology, the sites of resorption, their extent, and their severity showed differences.
CONCLUSIONS: With 14 genetic pathologies suspected to induce root resorptions, our findings are significant and enrich a previous classification. Among them, three metabolic disorders, three calcium-phosphorus metabolism disorders, and osteolysis disorders were identified.