Intervention planners use logic models to design evidence-based health behavior interventions. Logic models that capture the complexity of health behavior necessitate additional computational techniques to inform decisions with respect to the design of interventions.
Using empirical data from a real intervention, the present paper demonstrates how machine learning can be used together with fuzzy cognitive maps to assist in designing health behavior change interventions.
A modified Real Coded Genetic algorithm was applied on longitudinal data from a real intervention study. The dataset contained information about 15 determinants of fruit intake among 257 adults in the Netherlands. Fuzzy cognitive maps were used to analyze the effect of two hypothetical intervention scenarios designed by domain experts.
Simulations showed that the specified hypothetical interventions would have small impact on fruit intake. The results are consistent with the empirical evidence used in this paper.
Machine learning together with fuzzy cognitive maps can assist in building health behavior interventions with complex logic models. The testing of hypothetical scenarios may help interventionists finetune the intervention components thus increasing their potential effectiveness.

A new reconstruction approach that combines Reverse Time Migration (RTM) and Genetic Algorithms (GAs) is proposed for solving the inverse problem associated with transluminal shear wave elastography. The transurethral identification of the first thermal lesion generated by transrectal High Intensity Focused Ultrasound (HIFU) for the treatment of prostate cancer, was used to preliminarily test in silico the combined reconstruction method. The RTM method was optimised by comparing reconstruction images from several cross-correlation techniques, including a new proposed one, and different device configurations in terms of the number and arrangement of emitters and receivers of the conceptual transurethral probe. The best results were obtained for the new proposed cross-correlation method and a device configuration with 3 emitters and 32 receivers. The RTM reconstructions did not completely contour the shape of the HIFU lesion, however, as planned for the combined approach, the areas in the RTM images with high level of correlation were used to narrow down the search space in the GA-based technique. The GA-based technique was set to find the location of the HIFU lesion and the increment in stiffness and viscosity due to thermal damage. Overall, the combined approach achieves lower level of error in the reconstructed values, and in a shorter computational time, compared to the GA-based technique alone. The lowest errors were accomplished for the location of HIFU lesion, followed by the contrast ratio of stiffness between thermally treated tissue and non-treated normal tissue. The homologous ratio of viscosity obtained higher level of error. Further investigation considering diverse scenarios to be reconstructed and with experimental data is required to fully evaluate the feasibility of the combined approach.

Groundwater vulnerability assessment has nowadays evolved into an essential tool towards proper groundwater protection and management, while the DRASTIC method is included among the most widely applied vulnerability assessment methods. However, the high uncertainty of the DRASTIC method mainly associated with the subjectivity in assigning parameters ratings and weights has driven many researchers to apply various methods for improving its efficiency. In this context, in the present study, different techniques were implemented with the aim of modifying the DRASTIC framework and thus enhancing its performance for groundwater vulnerability assessment in the Bouficha aquifer, Tunisia. In a first stage, the land use type (L) was incorporated as an additional parameter in the typical DRASTIC framework, thus taking into consideration the impact of anthropogenic activities on groundwater vulnerability. Subsequently, the rating and weighting systems of the developed DRASTIC-L framework were modified through the application of statistical methods (DRASTIC-L-SA) and genetic algorithms (GA) (DRASTIC-L-GA) in an attempt to investigate and compare both linear and nonlinear modifications. To evaluate the various vulnerability frameworks, correlation between vulnerability values and nitrate concentrations, expressed as Spearman\'s rank correlation coefficient (ρ) and Correlation Index (CI), was examined. The results revealed that the DRASTIC-L-GA framework developed by applying a fully GA-based optimization procedure provided the highest values in terms of the performance metrics used, making it the most suitable for the study area. In addition, the aquifer under study was found to be less vulnerable to pollution when employing the typical DRASTIC framework instead of the modified ones, leading to the conclusion that the former substantially underestimates pollution potential in the study area.

Anaerobic digestion (AnD) is a process that allows the conversion of organic waste into a source of energy such as biogas, introducing sustainability and circular economy in waste treatment. AnD is an intricate process because of multiple parameters involved, and its complexity increases when the wastes are from different types of generators. In this case, a key point to achieve good performance is optimisation methods. Currently, many tools have been developed to optimise a single AnD plant. However, the study of a network of AnD plants and multiple waste generators, all in different locations, remains unexplored. This novel approach requires the use of optimisation methodologies with the capacity to deal with a highly complex combinatorial problem. This paper proposes and compares the use of three evolutionary algorithms: ant colony optimisation (ACO), genetic algorithm (GA) and particle swarm optimisation (PSO), which are especially suited for this type of application. The algorithms successfully solve the problem, using an objective function that includes terms related to quality and logistics. Their application to a real case study in Catalonia (Spain) shows their usefulness (ACO and GA to achieve maximum biogas production and PSO for safer operation conditions) for AnD facilities.

Optimizing global connectivity in spatial networks, either through rewiring or adding edges, can increase the flow of information and increase the resilience of the network to failures. Yet, rewiring is not feasible for systems with fixed edges and optimizing global connectivity may not result in optimal local connectivity in systems where that is wanted. We describe the local network connectivity optimization problem, where costly edges are added to a systems with an established and fixed edge network to increase connectivity to a specific location, such as in transportation and telecommunication systems. Solutions to this problem maximize the number of nodes within a given distance to a focal node in the network while they minimize the number and length of additional connections. We compare several heuristics applied to random networks, including two novel planar random networks that are useful for spatial network simulation research, a real-world transportation case study, and a set of real-world social network data. Across network types, significant variation between nodal characteristics and the optimal connections was observed. The characteristics along with the computational costs of the search for optimal solutions highlights the need of prescribing effective heuristics. We offer a novel formulation of the genetic algorithm, which outperforms existing techniques. We describe how this heuristic can be applied to other combinatorial and dynamic problems.

BACKGROUND: Polyphenols are the foremost measure of phytochemicals in Chinese dates due to their many potential health benefits such as averting cancers, reducing the risk of coronary artery disease, diuretic activity, myocardial stimulant, coronary dilator and muscle relaxant.
OBJECTIVE: To quantitate the polyphenols in Chinese dates using a data fusion approach with near-infrared (NIR) and mid-infrared (MIR) spectroscopy.
METHODS: A total of 80 Chinese dates samples were used for data acquisition from both NIR and MIR spectroscopy. The efficient spectral intervals were extracted by the synergy interval partial least square (Si-PLS) algorithm as input variables for NIR-MIR fusion model. A genetic algorithm (GA) was used to construct the model based on NIR-MIR fusion. The performance of the developed models was evaluated using correlation coefficients of calibration (R2 ) and prediction (r2 ), root mean square error of prediction (RMSEP), bias and residual prediction deviation (RPD).
RESULTS: The data fusion model based on the GA was superior compared to NIR and MIR build model. The optimal GA-fusion model yielded R2  = 0.9621, r2  = 0.9451, RPD = 2.44, calibration set bias = 0.004 and prediction set bias = 0.061, computing only 15 variables.
CONCLUSIONS: These findings reveal that integration of NIR and MIR is possible for the prediction of total polyphenol content in Chinese dates.

The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitors can be used to efficiently target it. In the present study, the multiple linear regression (MLR), and support vector machine (SVM) methods were used to interpret the chemical structural functionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structural information were described through various types of molecular descriptors and genetic algorithm (GA) was applied to decrease the complexity of inhibition pathway to a few relevant molecular descriptors. Non-linear method (GA-SVM) showed to be better than the linear (GA-MLR) method in terms of the internal and the external prediction accuracy. The SVM model, with high statistical significance (R2train = 0.938; R2test = 0.870), was found to be useful for estimating the inhibition activity of 17β-HSD3 inhibitors. The models were validated rigorously through leave-one-out cross-validation and several compounds as external test set. Furthermore, the external predictive power of the proposed model was examined by considering modified R2 and concordance correlation coefficient values, Golbraikh and Tropsha acceptable model criteria\'s, and an extra evaluation set from an external data set. Applicability domain of the linear model was carefully defined using Williams plot. Moreover, Euclidean based applicability domain was applied to define the chemical structural diversity of the evaluation set and training set.

There is an increased l-glutaminase market worldwide due to its relevant industrial applications. Salt tolerance l-glutaminases play a vital role in the increase of flavor of different types of foods like soya sauce and tofu. This chapter is presenting the economically viable l-glutaminases production in solid-state fermentation (SSF) by Aspergillus flavus MTCC 9972 as a case study. The enzyme production was improved following a three step optimization process. Initially mixture design (MD) (augmented simplex lattice design) was employed to optimize the solid substrate mixture. Such solid substrate mixture consisted of 59:41 of wheat bran and Bengal gram husk has given higher amounts of l-glutaminase. Glucose and l-glutamine were screened as a finest additional carbon and nitrogen sources for l-glutaminase production with help of Plackett-Burman Design (PBD). l-Glutamine also acting as a nitrogen source as well as inducer for secretion of l-glutaminase from A. flavus MTCC 9972. In the final step of optimization various environmental and nutritive parameters such as pH, temperature, moisture content, inoculum concentration, glucose, and l-glutamine levels were optimized through the use of hybrid feed forward neural networks (FFNNs) and genetic algorithm (GA). Through sequential optimization methods MD-PBD-FFNN-GA, the l-glutaminase production in SSF could be improved by 2.7-fold (453-1690U/g).

Quantitative structure-activity relationship (QSAR) study has been employed for predicting the inhibitory activities of the Hepatitis C virus (HCV) NS5B polymerase inhibitors . A data set consisted of 72 compounds was selected, and then different types of molecular descriptors were calculated. The whole data set was split into a training set (80 % of the dataset) and a test set (20 % of the dataset) using principle component analysis. The stepwise (SW) and the genetic algorithm (GA) techniques were used as variable selection tools. Multiple linear regression method was then used to linearly correlate the selected descriptors with inhibitory activities. Several validation technique including leave-one-out and leave-group-out cross-validation, Y-randomization method were used to evaluate the internal capability of the derived models. The external prediction ability of the derived models was further analyzed using modified r(2), concordance correlation coefficient values and Golbraikh and Tropsha acceptable model criteria\'s. Based on the derived results (GA-MLR), some new insights toward molecular structural requirements for obtaining better inhibitory activity were obtained.

Bruton\'s tyrosine kinase (BTK) plays a crucial role in B-cell activation and development, and has emerged as a new molecular target for the treatment of autoimmune diseases and B-cell malignancies. In this study, two- and three-dimensional quantitative structure-activity relationship (2D and 3D-QSAR) analyses were performed on a series of pyridine and pyrimidine-based BTK inhibitors by means of genetic algorithm optimized multivariate adaptive regression spline (GA-MARS) and comparative molecular similarity index analysis (CoMSIA) methods. Here, we propose a modified MARS algorithm to develop 2D-QSAR models. The top ranked models showed satisfactory statistical results (2D-QSAR: Q(2) = 0.884, r(2) = 0.929, r(2)pred = 0.878; 3D-QSAR: q(2) = 0.616, r(2) = 0.987, r(2)pred = 0.905). Key descriptors selected by 2D-QSAR were in good agreement with the conclusions of 3D-QSAR, and the 3D-CoMSIA contour maps facilitated interpretation of the structure-activity relationship. A new molecular database was generated by molecular fragment replacement (MFR) and further evaluated with GA-MARS and CoMSIA prediction. Twenty-five pyridine and pyrimidine derivatives as novel potential BTK inhibitors were finally selected for further study. These results also demonstrated that our method can be a very efficient tool for the discovery of novel potent BTK inhibitors.