背景:子宫内膜腺癌(EAC)是子宫内膜的恶性肿瘤。EAC是绝经后最常见的女性恶性肿瘤。大约40%的EAC患者与肥胖相关,与高血压相关。糖尿病,和高循环雌激素水平。前蛋白转化酶(PC)furin参与了EAC的发展。
结果:Furin是一种蛋白酶,属于枯草杆菌蛋白酶PC家族,称为PC枯草杆菌蛋白酶/kexin3型,可将前体蛋白转化为生物活性形式和产物。弗林蛋白酶的异常激活促进异常细胞增殖和癌症的发展。弗林蛋白酶促进血管生成,恶性细胞增殖,以及恶性细胞通过其促转移和致癌活性对组织的侵袭。弗林蛋白酶活性与EAC的恶性增殖相关。弗林蛋白酶的较高表达可能通过肾素原受体和整合素和金属蛋白酶17(ADAM17)的过表达来增加EAC的发育。同样,EAC中的炎症信号促进弗林蛋白酶的表达,并进一步传播恶性转化。
结论:Furin通过诱导增殖与EAC的发生和发展有关,入侵,和EAC恶性细胞的转移。弗林蛋白酶通过激活ADAM17,肾素原受体的表达诱导EAC的个体发育,CD109和TGF-β。同样,EAC介导的炎症促进弗林蛋白酶的表达,并进一步扩大肿瘤的生长和侵袭。
Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period. About 40% of patients with EAC are linked with obesity and interrelated with hypertension, diabetes mellitus, and high circulating estrogen levels. Proprotein convertase (PC)
furin was involved in the progression of EAC.
Furin is a protease enzyme belonging to the subtilisin PC family called PC subtilisin/kexin type 3 that converts precursor proteins to biologically active forms and products. Aberrant activation of
furin promotes abnormal cell proliferation and the development of cancer. Furin promotes angiogenesis, malignant cell proliferation, and tissue invasion by malignant cells through its pro-metastatic and oncogenic activities.
Furin activity is correlated with the malignant proliferation of EAC. Higher expression of furin may increase the development of EAC through overexpression of pro-renin receptors and disintegrin and metalloprotease 17 (ADAM17). As well, inflammatory signaling in EAC promotes the expression of furin with further propagation of malignant transformation.
Furin is associated with the development and progression of EAC through the induction of proliferation, invasion, and metastasis of malignant cells of EAC.
Furin induces ontogenesis in EAC through activation expression of ADAM17, pro-renin receptor, CD109, and TGF-β. As well, EAC-mediated inflammation promotes the expression of furin with further propagation of neoplastic growth and invasion.