治疗头颈癌的常规放射治疗方案通常伴随着蛀牙发作。辐射对矿化牙齿结构的影响尚不清楚。本系统综述旨在收集已记录的治疗辐射对牙齿化学物质的影响,结构和机械性能,与他们的调查手段有关。
系统搜索(2012年1月1日-2021年9月30日)术语为“放射治疗”,“辐射效应”,“牙釉质”,\"Dentin\",\"人类\"和\"放射治疗\"不是\"激光\"。
PubMed,搜索了DOSS和Embase数据库。
选定的研究比较了牙釉质,在体外或体内照射高达80Gy之前和之后的冠状和根部牙本质特性。
系统搜索确定了353篇不同的文章,28人符合纳入标准。他们的参考清单又提供了两个。22项研究评估了牙釉质的演变,9个评估的冠状牙本质和8个相关的根牙本质。冠状和根部牙本质结果表明,辐射对其有机基质有重大影响。牙釉质的化学性质较少改变。牙釉质和牙根牙本质的硬度被治疗辐射降低,但是对于冠状牙本质没有共识.
我们的发现揭示了一些有关牙本质有机基质的酶促降解机制的有趣信息,并强调牙齿硬组织表征需要材料科学方面的高度特异性专业知识。科学知识对于设计合适的协议是必要的,充分分析获得的数据,and,因此,提供相关结论。
更好地了解和理解牙釉质和牙本质降解的机制将有助于开发新的预防和治疗方法,以改善接受放射治疗的患者的医疗护理。
The conventional radiotherapy protocol to treat head-and-neck cancer is usually followed by tooth-decay onset. Radiation impact on mineralized tooth structures is not well-understood. This systematic
review aimed to collect the recorded effects of therapeutic radiation on tooth chemical, structural and mechanical properties, in relation with their means of investigation.
Systematic search (January 01 2012 - September 30 2021) terms were \"Radiotherapy\", \"Radiation effects\", \"Dental enamel\", \"Dentin\", \"Human\" and \"Radiotherapy\" NOT \"Laser\".
PubMed, DOSS and Embase databases were searched.
Selected studies compared dental enamel, coronal and root dentin properties before and after in vitro or in vivo irradiation up to 80 Gy.
The systematic search identified 353 different articles, with 28 satisfying inclusion criteria. Their reference lists provided two more. Twenty-two studies evaluated dental enamel evolution, nine assessed coronal dentin and eight concerned root dentin. Coronal and root dentin results indicate a major impact of the radiation on their organic matrix. Dental enamel\'s chemical properties are less modified. Enamel and root dentin\'s hardness are decreased by therapeutic radiation, but no consensus arises for coronal dentin.
Our findings revealed some interesting information about enzymatic degradation mechanisms of dentin organic matrix and highlighted that dental hard-tissue characterization requires highly specific expertise in materials science. That scientific knowledge is necessary to design suitable protocols, adequately analyze the obtained data, and, thus, provide relevant conclusions.
Better knowledge and understanding of the mechanisms involved in the degradation of enamel and dentin would enable development of new preventive and therapeutic methods for improved medical care of patients undergoing radiotherapy.