背景:儿童时期食物匮乏(FD)与晚年健康之间的关系已得到广泛研究;然而,关于儿童期食物匮乏与虚弱之间关系的研究很少。这项研究评估了儿童FD与中年和老年衰弱风险之间的关联。
方法:中国健康与退休纵向研究(CHARLS)的三波包括11,615名45岁以上的人,用于这项研究。根据FRAIL量表将虚弱作为疲劳的总和进行操作,阻力,步行,疾病,和体重减轻。通过自我报告的FD和历史内容来衡量儿童FD的经历和水平。使用Logistic混合效应模型和比例赔率排序逻辑回归模型来分析儿童FD与虚弱之间的关联。
结果:儿童FD增加了老年虚弱的几率(1.30,95%CI:1.26-1.36)。与轻度FD受试者相比,有极端FD经历的患者的虚弱风险增加(1.34,95%CI:1.26-1.43).在不同年龄暴露于饥饿的受试者都有增加的虚弱风险,与年龄较小的FD患者相比,年龄在6~12岁(1.15,95%CI:1.09~1.22)的FD患者的虚弱风险增加.调整所有协变量后,0-6岁FD的经验与6-12岁FD的经验之间的相互作用无统计学意义。
结论:我们的研究结果表明,儿童FD对中国老年人的虚弱有长期的影响。预防儿童FD可能会延迟甚至避免中老年人的虚弱出现。
BACKGROUND: The association between childhood food deprivation (FD) and health in later life has been extensively studied; however, studies on the association between childhood food deprivation and frailty are scarce. This
study assessed the associations between childhood FD and the risk of frailty at middle-age and old age.
METHODS: Three waves of the China Health and Retirement Longitudinal
Study (CHARLS), including 11,615 individuals aged over 45 years, were used for this research. Frailty was operationalized according to the FRAIL scale as a sum of fatigue, resistance, ambulation, illness, and the loss of weight. Childhood FD experiences and levels were measured by self-reported FD and historical content. Logistic mixed-effects models and proportional odds ordered logistic regression models were used to analyse the association between childhood FD and frailty.
RESULTS: Childhood FD increased the odds of frailty at old age (1.30, 95% CI: 1.26-1.36). Compared with subjects with mild FD, those with extreme FD experiences had increased risks of frailty (1.34, 95% CI: 1.26-1.43). Subjects exposed to hunger at different ages all had an increased risk of frailty, and subjects who had FD during ages 6-12 (1.15, 95% CI: 1.09-1.22) were more likely to have an increased risk of frailty than those who had experienced FD in younger ages. The interaction of experience of FD at ages 0-6 and the experience of FD at ages 6-12 is not statistically significant after adjusting all covariates.
CONCLUSIONS: Our findings suggest that childhood FD exerts long-lasting effects on frailty among older adults in China. The prevention of childhood FD may delay or even avert the emergence of frailty in people of middle-age and old age.