目的:该研究的目的是确定在牙科龋齿病变上应用二氟化银胺(SDF)后健康儿童唾液和尿液中的氟化物(F)和银(Ag)离子水平。
方法:从儿科牙科门诊招募了60名儿童(4-6岁,有3个以上的龋齿病变)。每个孩子,在基线时收集3ml未刺激的唾液样品,一小时,和SDF应用后24小时。同样,在SDF施用24小时之前和之后收集3ml尿样。氟离子选择电极(ISE)和电感耦合等离子体质谱法(ICPMS)测定F和Ag离子浓度,分别。
结果:平均值±标准偏差(SD)基线,1-h,和24小时唾液F浓度(ppm)分别为0.07±0.07、0.93±0.48和0.19±0.19,而平均基线和24小时尿F浓度(ppm)为0.33±0.20ppm和0.43±0.25ppm,分别。平均基线,1-h,和24小时唾液Ag浓度(ppb)分别为4.22±3.15、4198±350和56.93±37。平均基线和24小时尿Ag浓度(ppb)为2.80±2.93ppb和4.72±4.0ppb,分别。与基线相比,在施加SDF后1小时和24小时存在统计学上升高的F和Ag离子浓度。
结论:儿童应用SDF后24小时唾液和尿中F和Ag离子浓度显著升高。尿液中这些离子的显著高回收率表明系统吸收最小,因此,间歇性局部应用38%SDF的毒性风险最小.
OBJECTIVE: The purpose of the
study was to determine the
fluoride (F) and silver (Ag) ions levels in the saliva and urine of healthy children after silver diamine
fluoride (SDF) application on dental carious lesions.
METHODS: Sixty children (4-6 years with ≥ 3 caries lesions) were recruited from the outpatient department of Pediatric Dentistry. From each child, 3 ml unstimulated saliva samples were collected at baseline, one hour, and 24 h after SDF application. Similarly, 3 ml urine samples were collected prior to and after 24 h of SDF application. F and Ag ion concentrations were determined by
fluoride ion-selective electrode (ISE) and inductively coupled plasma mass spectrometry (ICPMS), respectively.
RESULTS: The mean ± standard deviation (SD) baseline, 1-h, and 24-h salivary F concentrations (ppm) were 0.07 ± 0.07, 0.93 ± 0.48, and 0.19 ± 0.19, respectively, while the mean baseline and 24-h urinary F concentrations (ppm) were 0.33 ± 0.20 ppm and 0.43 ± 0.25 ppm, respectively. The mean baseline, 1-h, and 24-h salivary Ag concentrations (ppb) were 4.22 ± 3.15, 4198 ± 350, and 56.93 ± 37, respectively. The mean baseline and 24-h urinary Ag concentrations (ppb) were 2.80 ± 2.93 ppb and 4.72 ± 4.0 ppb, respectively. There were statistically elevated F and Ag ion concentrations at 1 h and 24 h after SDF application as compared to the baseline.
CONCLUSIONS: Salivary and urinary F and Ag ions concentrations elevated significantly at 24 h following SDF applications in children. A significant high recovery of these ions in urine indicates minimal systemic absorption, thus intermittent topical application of 38% SDF has a minimal risk of toxicity.