成纤维细胞生长因子21(FGF21)已被认为可以改善肥胖有氧运动期间的新陈代谢。然而,运动干预的可变性导致了该领域的差异。因此,我们旨在系统回顾有关超重和肥胖背景下有氧运动对FGF21影响的现有文献.我们的搜索包括在PubMed中发现的2009年至2021年11月之间发表的原始文章,科学直接,Medline包括临床和临床前研究。研究,受试者或动物出现其他情况(例如,癌症,stroke),被排除在外。从最初的43项研究中,19项(临床研究=9;临床前研究=10)符合纳入本综述的条件。主要发现是,急性运动倾向于增加FGF21的循环水平。相比之下,慢性运动计划(≥4周)具有相反的作用,同时诱导脂肪组织中FGF受体和β-klotho的mRNA和蛋白质增加,肝脏,和骨骼肌。总之,临床和临床前研究均表明,有氧运动可改变循环和组织FGF21及其受体和共受体.未来的研究需要阐明机制,以及这些变化的生理和临床意义。
Fibroblast growth factor 21 (FGF21) has been suggested to improve metabolism during aerobic exercise in obesity. However, the variability of exercise interventions gives rise to discrepancies in the field. Therefore, we aimed to systematically
review the available literature regarding the effects of aerobic exercise on FGF21 in the context of overweight and obesity. Our search included original articles published between 2009 and November 2021 found in PubMed, Science Direct, and Medline. Clinical and preclinical studies were included. Studies, where subjects or animals presented with other conditions (e.g., cancer, stroke), were excluded. From an initial 43 studies, 19 (clinical studies = 9; preclinical studies = 10) were eligible for inclusion in this
review. The main findings were that acute exercise tended to increase circulatory levels of FGF21. In contrast, chronic exercise programs (≥4 weeks) had the opposite effect along with inducing mRNA and protein increases of FGF receptors and β-klotho in adipose tissue, liver, and skeletal muscle. In conclusion, both clinical and preclinical studies showed that aerobic exercise exerts changes in circulatory and tissue FGF21, along with its receptors and co-receptor. Future research is needed to elucidate the mechanisms, along with the physiological and clinical implications of these changes.