背景:肥胖已成为全球普遍存在的问题。莫林,一种传统的黄酮类化合物,用于治疗高血糖和高脂血症,在实验研究中已经证明了抗氧化和抗炎特性。本研究旨在探讨莫林在高脂饮食(HFD)大鼠中的抗肥胖潜力,并研究其作用是否通过PPARα调节介导。
方法:成年雄性Wistar白化病大鼠分为四组(n=8/组):正常,莫林(50mg/kg/BWT,oral),HFD,和HFD+莫林(50mg/kg/BWT,oral).连续17周每天施用治疗。
结果:莫林减轻了血糖水平的升高,降低了空腹血糖和胰岛素水平,以及HOMA-IR指数,在HFD喂养的大鼠中。此外,莫林减少了卡路里的摄入,最终体重,和皮下的肿块,附睾,腹膜,和这些老鼠的肠系膜脂肪。它还减轻了HFD喂养的大鼠收缩压的升高,并降低了血清甘油三酯的水平,胆固醇,游离脂肪酸,LDL-c,和瘦素,同时增加正常和HFD喂养大鼠的HDL-c和脂联素水平。此外,在HFD喂养的大鼠中,莫林可以恢复正常的肝脏结构并减少脂肪液泡积累。值得注意的是,它上调正常和HFD喂养的大鼠肝脏和白色脂肪组织中PPARα的mRNA水平。
结论:这些研究结果表明,莫林可能用于增强白色脂肪组织中的脂肪酸氧化和减轻肥胖,保证对其治疗应用进行进一步的临床研究。
BACKGROUND: Obesity has become a widespread issue globally. Morin, a flavonoid with traditional use in managing hyperglycemia and hyperlipidemia, has demonstrated antioxidant and anti-inflammatory properties in experimental studies. This research aims to explore the anti-obesity potential of morin in rats subjected to a high-fat diet (HFD) and investigate whether its effects are mediated through PPARα regulation.
METHODS: Young adult male Wistar albino rats were divided into four groups (n = 8/group): normal, morin (50 mg/kg/BWT, oral), HFD, and HFD + morin (50 mg/kg/BWT, oral). Treatments were administered daily for 17 consecutive weeks.
RESULTS: Morin mitigated the elevation in glucose levels and decreased fasting glucose and insulin levels, along with the HOMA-IR index, in HFD-fed rats. Furthermore, morin reduced calorie intake, final body weights, and the masses of subcutaneous, epididymal, peritoneal, and mesenteric fat in these rats. It also attenuated the rise in systolic blood pressure in HFD-fed rats and decreased serum levels of triglycerides, cholesterol, free fatty acids, LDL-c, and leptin, while increasing levels of HDL-c and adiponectin in both normal and HFD-fed rats. Moreover, morin restored normal liver structure and reduced fat vacuole accumulation in HFD-fed rats. Notably, it upregulated mRNA levels of PPARα in the livers and white adipose tissue of both normal and HFD-fed rats.
CONCLUSIONS: These findings suggest the potential use of morin to enhance fatty acid oxidation in white adipose tissue and mitigate obesity, warranting further clinical investigation into its therapeutic applications.