肿瘤相关巨噬细胞(TAM)是浸润肿瘤微环境(TME)的重要免疫细胞。最近的研究表明,TAM在表型方面表现出多样性,函数,时间,和空间分布,这允许TAM亚型的进一步分类。脂肪酸氧化(FAO)的代谢效率在TAM亚型之间有所不同。粮农组织与活性氧(ROS)的产生密切相关,在氧化应激等过程中发挥作用。目前的证据表明,粮农组织和ROS可以影响TAMs的招募,极化,和吞噬能力单独或组合,从而影响肿瘤进展。但与这些关系相关的具体机制仍需进一步调查。我们将从ROS和TAMs三个方面综述TAMs与肿瘤发生发展关系的研究现状,粮农组织和TAM,以及粮农组织的相互联系,ROS,和TAM。
Tumor-associated macrophages (TAMs) are significant immunocytes infiltrating the tumor microenvironment(TME). Recent research has shown that TAMs exhibit diversity in terms of their phenotype, function, time, and spatial distribution, which allows for further classification of TAM subtypes. The metabolic efficiency of fatty acid oxidation (FAO) varies among TAM subtypes. FAO is closely linked to the production of reactive oxygen species (ROS), which play a role in processes such as oxidative stress. Current evidence demonstrates that FAO and ROS can influence TAMs\' recruitment, polarization, and phagocytosis ability either individually or in combination, thereby impacting tumor progression. But the specific mechanisms associated with these relationships still require further investigation. We will
review the current status of research on the relationship between TAMs and tumor development from three aspects: ROS and TAMs, FAO and TAMs, and the interconnectedness of FAO, ROS, and TAMs.