■凝血因子(F)II(FII)水平升高,FV,FVII,FIX,FX,FXI通常与冠心病有关,缺血性卒中,静脉血栓形成(VT)。然而,关于它们与全因死亡率的相关性的研究很少.
■我们探讨了FII水平是否升高,FV,FVII,FIX,FX,和FXI与室性心动过速患者和普通人群死亡风险增加相关.
■我们随访了1919例既往VT患者和2800名年龄和性别匹配的社区对照者,他们测量了凝血因子水平。高凝血因子被定义为对照中>90百分位数的正常值。Cox回归分析根据年龄和性别以及室性心动过速患者或对照组进行了调整。
■患者和对照组的中位年龄为48岁,女性比男性稍多。患者的中位随访时间为6.1年,对照组为5.0年,患者和对照组分别有79例和60例死亡.没有FII的关联,FV,FVII,FIX,FX,和FXI患者或对照个体的全因死亡率。
■FII水平升高,FV,FVII,FIX,FX,FXI水平可能与全因死亡风险增加无关.只有心脏死亡,发现了与高FX和FXI的关联,这证实了以前的研究结果,但是数字很小。
UNASSIGNED: Elevated levels of coagulation factors (F) II (FII), FV, FVII, FIX, FX, and FXI have often been related with coronary heart disease, ischemic stroke, and venous thrombosis (VT). However, there are few studies on their associations with all-cause mortality.
UNASSIGNED: We explored whether elevated levels of FII, FV, FVII, FIX, FX, and FXI are associated with an increased risk of death in patients who had VT and in individuals from the general population.
UNASSIGNED: We followed 1919 patients with previous VT and 2800 age- and sex-matched community controls in whom coagulation factor levels were measured. A high coagulation factor was defined as the >90th percentile of normal in the controls. Cox regression analyses were adjusted for age and sex and for being a patient with VT or being a control subject.
UNASSIGNED: The median age at time of enrolment was 48 years for both patients and controls, and slightly more women than men were followed. Over a median follow-up of 6.1 years for patients and 5.0 years for controls, there were 79 and 60 deaths in patient and controls respectively. There was no association of FII, FV, FVII, FIX, FX, and FXI with all-cause mortality in patients or in control individuals.
UNASSIGNED: Elevated levels of FII, FV, FVII, FIX, FX, and FXI levels may not be associated with an increased risk of all-cause mortality. Only for cardiac death, an association with high FX and FXI was found, which confirms the findings of previous studies, but numbers were small.