%0 Journal Article
%T Clinical and Molecular Study of Common Thrombophilia Mutation Prothrombin G20210A.
%A Angelopoulou A
%A Vlachakis D
%A Chrousos GP
%A Cosmidis N
%A Yapijakis C
%A Angelopoulou A
%A Vlachakis D
%A Chrousos GP
%A Cosmidis N
%A Yapijakis C
%J Adv Exp Med Biol
%V 1339
%N 0
%D 2021
%M 35023122
%F 3.65
%R 10.1007/978-3-030-78787-5_40
%X <B>BACKGROUND: </B>One of the most common genetic causes associated with thrombophilia is mutation G20210A of the coagulation factor II (F2) gene.<BR><B>METHODS: </B>Data collected from 355 unrelated Greeks examined for the mutation G20210A over a period of two decades were anonymously analyzed.<BR><B>RESULTS: </B>The statistical analysis confirmed the importance of F2 G20210A in thrombosis and the significance of a positive family history of thrombosis. An interesting finding was the increased prevalence of G20210A in men with thrombotic events aged >40 years.<BR><B>CONCLUSIONS: </B>This study highlighted the great value of a positive family history of thrombosis and the importance of testing for this common mutation as a putative prevention strategy and a future biomarker for thrombophilia.