Epidemiologic Studies

流行病学研究
  • 文章类型: Journal Article
    自我报告的身高和体重测量通常用于大型流行病学研究。然而,对这些自我报告措施的有效性和可靠性仍然存在担忧。本系统评价的目的是总结和评估测量和自我报告的体重和身高数据的比较有效性,并推荐策略,以提高跨研究的自我报告数据收集的可靠性。本系统审查采用了PRISMA指南。四个在线来源,包括PubMed,Medline,谷歌学者,和CINAHL,被利用了。共筛选17800篇,根据确定的纳入和排除标准,有10项研究符合纳入SLR的条件.研究结果表明,根据类内相关系数和Bland-Altman地块,测量和自我报告的体重和身高之间具有良好的一致性。总的来说,测量的体重和身高具有更高的有效性和可靠性(ICC>0.9;LOA<1SD)。然而,由于社会压力和自尊问题等偏见,女性低估了她们的体重,而男人夸大了自己的身高。实质上,自我报告的措施仍然是有价值的指标,以补充有限的直接人体测量数据,特别是在大规模调查中。然而,解决潜在的偏见来源至关重要。
    Self-reported measures of height and weight are often used in large epidemiological studies. However, concerns remain regarding the validity and reliability of these self-reported measures. The aim of this systematic review was to summarise and evaluate the comparative validity of measured and self-reported weight and height data and to recommend strategies to improve the reliability of self-reported-data collection across studies. This systematic review adopted the PRISMA guidelines. Four online sources, including PubMed, Medline, Google Scholar, and CINAHL, were utilised. A total of 17,800 articles were screened, and 10 studies were eligible to be included in the SLR based on the defined inclusion and exclusion criteria. The findings from the studies revealed good agreement between measured and self-reported weight and height based on intra-class correlation coefficient and Bland-Altman plots. Overall, measured weight and height had higher validity and reliability (ICC > 0.9; LOA < 1 SD). However, due to biases such as social pressure and self-esteem issues, women underreported their weight, while men overreported their height. In essence, self-reported measures remain valuable indicators to supplement the restricted direct anthropometric data, particularly in large-scale surveys. However, it is essential to address potential sources of bias.
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  • 文章类型: Journal Article
    背景:先前通过荟萃分析研究了镁(Mg)摄入量与抑郁症的关系。然而,由于数据有限,未进行剂量反应分析.
    目的:考虑到最近发表的文章,本研究进行了系统评价和剂量-反应荟萃分析,以总结成人膳食镁摄入量与抑郁症的关系.
    方法:Medline(PubMed),ISIWebofScience,Scopus,和谷歌学者进行了全面搜索,直到2023年8月。
    方法:纳入了观察性研究,这些研究报告了成年人饮食中Mg摄入量与抑郁之间的关系,并提取了它们的数据。
    方法:本研究共纳入了来自10个横断面研究和3个队列研究的63214名参与者。汇集来自12项研究(包括50275名参与者)的15种效应大小表明,镁摄入量最高的个体患抑郁症的风险降低了34%。与镁摄入量最低的人群相比(RR:0.66;95%CI:0.57,0.78)。此外,线性剂量-反应分析显示,每增加100mg/d的镁摄入量与抑郁风险降低7%相关(RR:0.93;95%CI:0.90,0.96).此外,基于非线性剂量响应分析,Mg摄入量从170mg/d增加至370mg/d与抑郁风险降低相关.还对9项具有代表性的研究(49558名参与者)进行了分析,在荟萃分析(RR:0.71;95%CI:0.61,0.83)和线性(RR:0.93;95%CI:0.90,0.96)和非线性剂量反应分析中也发现了相似的结果.
    结论:目前的研究表明,在一般和代表性成人人群中,膳食镁摄入量与抑郁风险呈剂量-反应关系。
    背景:PROSPERO注册号。CRD42024506570。
    BACKGROUND: The relation of magnesium (Mg) intake with depression was previously investigated by meta-analyses. However, due to limited data, a dose-response analysis was not performed.
    OBJECTIVE: Considering the recently published articles, a systematic review and dose-response meta-analysis was conducted to summarize the relation of dietary Mg intake with depression in adults.
    METHODS: Medline (PubMed), ISI Web of Science, Scopus, and Google Scholar were comprehensively searched up to August 2023.
    METHODS: Observational studies that reported the relation of dietary Mg intake and depression in adults were included and their data were extracted.
    METHODS: A total of 63 214 participants from 10 cross-sectional and 3 cohort studies were included in the current study. Pooling 15 effect sizes from 12 studies (including 50 275 participants) revealed that individuals with the highest Mg intake had a 34% lower risk of depression, compared with those with the lowest Mg intake (RR: 0.66; 95% CI: 0.57, 0.78). Moreover, the linear dose-response analysis revealed that each 100-mg/d increment in Mg intake was associated with a 7% reduced risk of depression (RR: 0.93; 95% CI: 0.90, 0.96). Additionally, based on nonlinear dose-response analysis, increasing Mg intake from 170 to 370 mg/d was associated with a reduced risk of depression. Analyses were also conducted on 9 studies (49 558 participants) with representative populations, and similar results were found in the meta-analysis (RR: 0.71; 95% CI: 0.61, 0.83) and linear (RR: 0.93; 95% CI: 0.90, 0.96) and nonlinear dose-response analysis.
    CONCLUSIONS: The current study shows an inverse dose-dependent association between dietary Mg intakes and risk of depression in both a general and representative population of adults in a dose-response manner.
    BACKGROUND: PROSPERO registration no. CRD42024506570.
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  • 文章类型: Journal Article
    背景:牙科植入物被广泛用作缺失牙齿的可靠替代品。然而,至关重要的是建立,仅通过前瞻性队列研究,牙周炎病史是否确实构成种植失败的重要危险因素。
    方法:2022年10月在几个电子数据库中进行了系统的文献检索,随后进行了手动更新。仅包括评估植入物装载后≥1年的植入物(丢失)率的原始前瞻性队列研究。计算对数风险比和加权平均差。使用随机效应荟萃分析对研究结果进行总结,通过试验序贯分析进行评估。纽卡斯尔-渥太华量表评估了研究偏倚,GRADE方法评估了证据的确定性/质量。
    结果:共14篇报告了12项前瞻性队列研究的出版物。由于缺乏随机临床试验,证据确定性/质量较低,在≤5年(OR=1.65;95%CI:1.12-2.44;p=0.012)和>5年(OR=2.36;95%CI:1.13-4.95;p=0.023)的随访中,有牙周炎病史的患者的失败几率明显更高。种植体周围炎的发生率(OR=5.93;95%CI:2.75-12.8;p<0.001)和边缘骨丢失的加权平均值(WM)(WM差异=0.75mm;95%CI:0.18-10.3;p<0.05)在牙周受损组中具有统计学意义,而两组种植体周围探查深度无显著差异。
    结论:牙周炎病史可以被认为是种植体失败的重要危险因素。种植体周围炎,和更大的边缘骨质流失。
    BACKGROUND: Dental implants are widely employed as dependable replacements for lost teeth. However, it is crucial to establish, solely through prospective cohort studies, whether a history of periodontitis indeed constitutes a significant risk factor for implant failure.
    METHODS: A systematic literature search was conducted in October 2022 in several electronic databases with subsequent manual updates. Only original prospective cohort studies evaluating the implant (loss) rate ≥1 year after implant loading were included. Logarithmic risk ratio and weighted mean differences were calculated. Study results were summarized using random effects meta-analyses evaluated by trial sequential analyses. The Newcastle-Ottawa scale evaluated study bias and the GRADE approach assessed the certainty/quality of the evidence.
    RESULTS: A total of 14 publications reporting on 12 prospective cohort studies were included. Low evidence certainty/quality evidence due to the absence of randomized clinical trials revealed significantly greater odds of failure in patients with a history of periodontitis at follow-ups both after ≤5 years (RR = 1.62; 95% CI: 1.71-2.37; p = 0.013) and >5 years (RR = 2.26; 95% CI: 1.12-4.53; p = 0.023). The incidence of peri-implantitis (RR = 4.09; 95% CI: 1.93-8.58; p < 0.001) and the weighted mean (WM) of marginal bone loss (WM difference = 0.75 mm; 95% CI: 0.18-1.31; p < 0.05) were statistically significantly greater in the periodontally compromised group, whereas there was no significant difference between the two groups for peri-implant probing depth.
    CONCLUSIONS: A history of periodontitis can be considered a significant risk factor for incident implant failure, peri-implantitis, and greater marginal bone loss.
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  • 文章类型: Journal Article
    目的:确定非酒精性脂肪性肝病(NAFLD)与肌肉减少症发病率的相关性。
    方法:观察性临床研究的系统评价和荟萃分析。
    方法:成人NAFLD。
    方法:数据库,如PubMed、Embase,从每个数据库开始到2023年4月4日,搜索了Cochrane和WebofScience的合格研究。所有关于NAFLD和肌肉减少症之间关联的横断面研究均纳入本研究。纳入研究的质量和偏倚风险使用机构的医疗保健研究和质量清单进行评估。采用STATAV.15.1软件进行统计分析。
    结果:在检索到的1524篇文章中,这次审查包括24人,涉及88609人。我们的研究结果表明,NAFLD组的肌肉减少症患病率高于对照组(汇总OR1.74,95%CI1.39至2.17)。在按地区分组分析中,在亚洲组中,NAFLD患者出现肌肉减少症的风险增加(合并OR1.97,95%CI1.54至2.51),而在美国和欧洲人群中,NAFLD患者与肌肉减少症的风险没有统计学上的显著关联,美国组的合并OR为1.31(95%CI0.71至2.40),欧洲组的合并OR为0.99(95%CI0.21至4.69)。在敏感性分析中观察到类似的结果,未观察到发表偏倚的证据.
    结论:目前的研究表明NAFLD与肌少症呈显著正相关,这可能会受到区域因素的影响。本研究为NAFLD与肌肉减少症的关系提供相关性依据,有助于寻找针对NAFLD的肌肉减少症的质量策略。
    OBJECTIVE: To determine the association of non-alcoholic fatty liver disease (NAFLD) with the incidence of sarcopenia.
    METHODS: Systematic review and meta-analysis of observational clinical studies.
    METHODS: Adults with NAFLD.
    METHODS: Databases such as PubMed, Embase, Cochrane and Web of Science were searched for eligible studies published from the inception of each database up to 4 April 2023. All cross-sectional studies on the association between NAFLD and sarcopenia were included in this study. The quality of the included studies and risk of bias was assessed using the Agency for Healthcare Research and Quality checklist. STATA V.15.1 software was used for statistical analysis.
    RESULTS: Of the 1524 retrieved articles, 24 were included in this review, involving 88 609 participants. Our findings showed that the prevalence of sarcopenia was higher in the NAFLD group than in the control group (pooled OR 1.74, 95% CI 1.39 to 2.17). In a subgroup analysis by region, patients with NAFLD showed an increased risk of sarcopenia (pooled OR 1.97, 95% CI 1.54 to 2.51) in the Asian group, whereas patients with NAFLD had no statistically significant association with the risk of sarcopenia in the American and European groups, with a pooled OR of 1.31 (95% CI 0.71 to 2.40) for the American group and a pooled OR of 0.99 (95% CI 0.21 to 4.69) for the European group. Similar results were observed in the sensitivity analysis, and no evidence of publication bias was observed.
    CONCLUSIONS: The current study indicated a significant positive correlation between NAFLD and sarcopenia, which may be affected by regional factors. This study provides the correlation basis for the relationship between NAFLD and sarcopenia and helps to find the quality strategy of sarcopenia targeting NAFLD.
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  • 文章类型: Journal Article
    目标:气候变化是一个重大的全球性问题,包括对空气质量和人类福祉的影响。这篇综述调查了不同气候变化情景下空气污染导致的非传染性疾病(NCDs)的预测。
    方法:本系统评价是根据2020年系统评价和荟萃分析流程检查表的首选报告项目进行的。建立了人口暴露结果框架。人口是指所有年龄的全球总人口,感兴趣的是空气污染及其预测,结果是根据死亡率的健康指数,空气污染和疾病负担(BoD)引起的非传染性疾病的发生,发病率,残疾调整寿命年,多年的生命损失和多年的生活与残疾。
    方法:WebofScience,搜索了OvidMEDLINE和EBSCOhost数据库,以查找2005年至2023年发表的文章。
    方法:使用修改后的清单评估生态研究质量的量表对符合条件的文章进行了评估。
    方法:搜索了两名审阅者,使用标准化方法独立筛选和选择纳入的研究。使用修改后的生态研究清单量表评估偏倚风险。结果是根据可归因于空气污染的非传染性疾病管理局的预测进行总结的。
    结果:本综述包括来自不同国家的11项研究。大多数研究专门调查了各种空气污染物,特别是颗粒物<2.5µm(PM2.5),氮氧化物和臭氧。这些研究使用了耦合的空气质量和气候建模方法,主要使用浓度-响应函数模型预测健康影响。空气污染导致的非传染性疾病包括心血管疾病(CVD),呼吸道疾病,中风,缺血性心脏病,冠心病和下呼吸道感染。值得注意的是,在促进减少空气污染的情况下,由于空气污染导致的非传染性疾病管理局预计将减少,碳排放和土地利用与可持续社会经济学。相反,预计非传染性疾病管理局将在人口数量增加的情况下增加,社会贫困和人口老龄化。
    结论:纳入的研究广泛报道了过早死亡率的增加,CVD和呼吸系统疾病可归因于PM2.5。未来的非传染性疾病预测研究应在预测气候变化时代空气污染造成的非传染性疾病的BoD时考虑排放和人口变化。
    CRD42023435288。
    OBJECTIVE: Climate change is a major global issue with significant consequences, including effects on air quality and human well-being. This review investigated the projection of non-communicable diseases (NCDs) attributable to air pollution under different climate change scenarios.
    METHODS: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 flow checklist. A population-exposure-outcome framework was established. Population referred to the general global population of all ages, the exposure of interest was air pollution and its projection, and the outcome was the occurrence of NCDs attributable to air pollution and burden of disease (BoD) based on the health indices of mortality, morbidity, disability-adjusted life years, years of life lost and years lived with disability.
    METHODS: The Web of Science, Ovid MEDLINE and EBSCOhost databases were searched for articles published from 2005 to 2023.
    METHODS: The eligible articles were evaluated using the modified scale of a checklist for assessing the quality of ecological studies.
    METHODS: Two reviewers searched, screened and selected the included studies independently using standardised methods. The risk of bias was assessed using the modified scale of a checklist for ecological studies. The results were summarised based on the projection of the BoD of NCDs attributable to air pollution.
    RESULTS: This review included 11 studies from various countries. Most studies specifically investigated various air pollutants, specifically particulate matter <2.5 µm (PM2.5), nitrogen oxides and ozone. The studies used coupled-air quality and climate modelling approaches, and mainly projected health effects using the concentration-response function model. The NCDs attributable to air pollution included cardiovascular disease (CVD), respiratory disease, stroke, ischaemic heart disease, coronary heart disease and lower respiratory infections. Notably, the BoD of NCDs attributable to air pollution was projected to decrease in a scenario that promotes reduced air pollution, carbon emissions and land use and sustainable socioeconomics. Contrastingly, the BoD of NCDs was projected to increase in a scenario involving increasing population numbers, social deprivation and an ageing population.
    CONCLUSIONS: The included studies widely reported increased premature mortality, CVD and respiratory disease attributable to PM2.5. Future NCD projection studies should consider emission and population changes in projecting the BoD of NCDs attributable to air pollution in the climate change era.
    UNASSIGNED: CRD42023435288.
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  • 文章类型: Meta-Analysis
    目的:一部分浅表静脉血栓形成(SVT)患者的血块向深静脉血栓形成(DVT)和/或肺栓塞(PE)传播。本系统评价的目的是确定所有临床相关的横断面和预后因素,以预测SVT患者的血栓并发症。
    方法:系统评价。
    方法:系统搜索PubMed/MEDLINE和Embase,直至2023年3月3日。
    方法:针对SVT患者的原始研究,DVT和/或PE作为结果,并呈现横断面或预后预测因素。
    用于预测因素研究的系统评价预测模型(CHARMS)清单的关键评估和数据提取用于系统提取研究特征。根据确定的预测因素,提取了单变量和多变量预测结果关联的相关估计,如OR和HR。在森林地块中总结了最频繁报告的预测因子的关联估计,并提出了具有异质性的荟萃分析。预后研究质量(QUIPS)工具用于偏倚风险评估和建议分级,评估,用于评估证据确定性的开发和评估(等级)。
    结果:纳入22项研究(n=10111例患者)。报道最多的预测因素是高年龄,男性,静脉血栓栓塞(VTE)病史,没有静脉曲张和癌症。汇总效应估计值是异质的,从横断面预测癌症的OR3.12(95%CI1.75至5.59)到预后预测高年龄的OR0.92(95%CI0.56至1.53)。证据水平被评为非常低。大多数研究都有高或中等偏倚风险。
    结论:尽管预测因子的汇总估计年龄高,男性,VTE的历史,癌症和静脉曲张的缺乏单独显示了预测潜力,研究设计的可变性,缺乏多变量调整和高偏差风险阻碍了坚定的结论。高品质,多变量研究对于识别个体SVT风险特征是必要的。
    CRD42021262819。
    OBJECTIVE: A subset of patients with superficial venous thrombosis (SVT) experiences clot propagation towards deep venous thrombosis (DVT) and/or pulmonary embolism (PE). The aim of this systematic review is to identify all clinically relevant cross-sectional and prognostic factors for predicting thrombotic complications in patients with SVT.
    METHODS: Systematic review.
    METHODS: PubMed/MEDLINE and Embase were systematically searched until 3 March 2023.
    METHODS: Original research studies with patients with SVT, DVT and/or PE as the outcome and presenting cross-sectional or prognostic predictive factors.
    UNASSIGNED: The CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling (CHARMS) checklist for prognostic factor studies was used for systematic extraction of study characteristics. Per identified predictive factor, relevant estimates of univariable and multivariable predictor-outcome associations were extracted, such as ORs and HRs. Estimates of association for the most frequently reported predictors were summarised in forest plots, and meta-analyses with heterogeneity were presented. The Quality in Prognosis Studies (QUIPS) tool was used for risk of bias assessment and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) for assessing the certainty of evidence.
    RESULTS: Twenty-two studies were included (n=10 111 patients). The most reported predictive factors were high age, male sex, history of venous thromboembolism (VTE), absence of varicose veins and cancer. Pooled effect estimates were heterogenous and ranged from OR 3.12 (95% CI 1.75 to 5.59) for the cross-sectional predictor cancer to OR 0.92 (95% CI 0.56 to 1.53) for the prognostic predictor high age. The level of evidence was rated very low to low. Most studies were scored high or moderate risk of bias.
    CONCLUSIONS: Although the pooled estimates of the predictors high age, male sex, history of VTE, cancer and absence of varicose veins showed predictive potential in isolation, variability in study designs, lack of multivariable adjustment and high risk of bias prevent firm conclusions. High-quality, multivariable studies are necessary to be able to identify individual SVT risk profiles.
    UNASSIGNED: CRD42021262819.
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  • 文章类型: Systematic Review
    背景:母婴健康表明,在孕前和妊娠期,产妇营养的关键影响,一些遗传变异也起着重要作用。我们的系统评价概述了流行病学研究,探索遗传变异之间的相互作用,母亲的饮食习惯,和新生儿和/或产妇妊娠结局。
    方法:从成立到2023年6月,我们对PubMed进行了全面的文献检索,Embase,和WebofScience数据库。
    结果:在总共29项流行病学研究中,进行了11项研究,以探索遗传变异与饮食因素之间的相互作用,关注与妊娠糖尿病相关的风险,妊娠高血压疾病,复发性自然流产,反复妊娠丢失,缺铁性贫血,和妊娠期体重增加。关于新生儿结局,六项研究调查了遗传变异之间的相互作用,饮食因素,和人体测量,虽然有8项研究深入研究胚胎发育异常,两项针对早产的研究,两项研究探讨了其他新生儿结局。
    结论:深入了解基因-饮食相互作用可能有助于开发高度个性化的母婴营养方法,以及探索疾病预防和促进母亲及其后代长期福祉的潜在影响。
    BACKGROUND: Maternal-child health suggests the critical impact of maternal nutrition during the pre-conception and gestational periods, with some genetic variants also playing a significant role. Our systematic review provides an overview of epidemiological studies exploring the interactions between genetic variants, maternal dietary habits, and neonatal and/or maternal pregnancy outcomes.
    METHODS: From its inception until June 2023, we conducted a comprehensive literature search on PubMed, Embase, and Web of Science databases.
    RESULTS: On a total of 29 epidemiological studies, 11 studies were conducted to explore the interplay between genetic variants and dietary factors, focusing on the risks associated with gestational diabetes mellitus, hypertensive disorders of pregnancy, recurrent spontaneous abortion, recurrent pregnancy loss, iron deficiency anemia, and gestational weight gain. Concerning neonatal outcomes, six studies investigated the interplay between genetic variants, dietary factors, and anthropometric measures, while eight studies delved into abnormal embryonic development, two studies focused on preterm birth, and two studies explored other neonatal outcomes.
    CONCLUSIONS: Deeply understanding gene-diet interactions could be useful in developing highly personalized approaches to maternal and child nutrition, as well as in exploring the potential implications in disease prevention and the promotion of the long-term well-being of both mothers and their offspring.
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  • 文章类型: Journal Article
    背景:多项研究调查了儿童和青少年血清维生素D与血脂异常之间的关系,但是调查结果是矛盾的。
    目的:目前的系统评价和剂量反应荟萃分析调查了儿童和青少年血清维生素D与血脂异常的关系。
    方法:ISIWebofScience,Scopus,MEDLINE(PubMed),EMBASE数据库,和谷歌学者,被搜索到2022年12月。
    方法:纳入了调查儿童血清维生素D水平类别中血脂异常几率的观察性研究,并提取了他们的数据。
    方法:汇集来自15项研究(39342名参与者)的17种效应大小显示,血清维生素D水平较高的受试者出现高甘油三酯血症的几率降低了27%(比值比[OR]=0.73;95%置信区间[CI]:0.60,0.88)。来自16项研究(39718名参与者)的18种效应大小的荟萃分析表明,最高和最低的血清维生素D与低高密度脂蛋白胆固醇(HDL-c)降低22%的几率相关(OR=0.78;95%CI:0.66,0.91)。此外,发现血清维生素D与血脂异常几率之间的非线性关联:25-羟维生素D值从35nmol/L升高到55nmol/L与高甘油三酯血症几率下降趋势相关。高低密度脂蛋白胆固醇血症,高胆固醇血症,和低HDL-胆固醇血症。然而,未观察到显著的线性关联.根据建议的分级,评估,开发和评估(等级),所有证据的确定性被评为高.
    结论:这项荟萃分析显示,儿童和青少年的25-羟维生素D水平与血清甘油三酯和HDL-c异常的几率呈负相关。血清维生素D从35nmol/L增加到55nmol/L与血清甘油三酯异常几率的降低趋势相关。HDL-c,低密度脂蛋白胆固醇,和儿童的总胆固醇。
    背景:PROSPERO注册号。42023400787。
    BACKGROUND: Several studies have investigated the relationship between serum vitamin D and dyslipidemia in children and adolescents, but the findings have been contradictory.
    OBJECTIVE: The current systematic review and dose-response meta-analysis investigated the serum vitamin D - dyslipidemia relationship in children and adolescents.
    METHODS: ISI Web of Science, Scopus, MEDLINE (PubMed), EMBASE databases, and Google Scholar, were searched up to December 2022.
    METHODS: Observational studies that investigated the odds of dyslipidemia in categories of serum vitamin D levels in children were included, and their data were extracted.
    METHODS: Pooling of 17 effect sizes from 15 studies (39 342 participants) showed that subjects with higher serum vitamin D had 27% lower odds of hypertriglyceridemia (odds ratio [OR] = 0.73; 95% confidence interval [CI]: 0.60, 0.88). A meta-analysis of 18 effect sizes from 16 studies (39 718 participants) illustrated that highest vs lowest serum vitamin D was related to 22% lower odds of low high-density lipoprotein cholesterol (HDL-c) (OR = 0.78; 95% CI: 0.66, 0.91). Also, a nonlinear association between serum vitamin D and odds of abnormal lipid profile was found: elevating values of 25-hydroxyvitamin D from 35 nmol/L to 55 nmol/L was associated with a decreasing trend in odds of hypertriglyceridemia, hyper low-density lipoprotein cholesterolemia, hypercholesterolemia, and hypo HDL-cholesterolemia. However, no significant linear association was observed. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE), the certainty of all evidence was rated as high.
    CONCLUSIONS: This meta-analysis revealed that the level of 25-hydroxyvitamin D was inversely related to odds of abnormal serum triglycerides and HDL-c in children and adolescents. Increasing serum vitamin D from 35 nmol/L to 55 nmol/L was associated with a decreasing trend in the odds of abnormal serum triglycerides, HDL-c, low-density lipoprotein cholesterol, and total cholesterol in children.
    BACKGROUND: PROSPERO registration no. 42023400787.
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  • 文章类型: Journal Article
    背景:术语“问题饮酒”包括一系列酒精问题,从过量或大量饮酒到饮酒障碍。饮酒问题是全球死亡和残疾的主要风险因素。它以不同的方式被衡量和概念化,这使得很难确定问题酒精使用的常见风险因素。这项范围审查旨在综合有关饮酒问题评估的知识,其规模和相关因素。
    方法:四个数据库(PubMed,Embase,PsycINFO,从成立之初到2023年11月25日,搜索了全球指数Medicus)和GoogleScholar。如果研究的重点是15岁及以上的人,以人群为基础的研究报告了酒精使用问题,并以英语发表。本综述是根据“系统综述和Meta分析的首选报告项目扩展范围”中的指南报告的。使用纽卡斯尔-渥太华量表进行关键评估。
    结果:从确定的14296条记录中,10749进行了标题/摘要筛选,其中评估了352篇全文,并纳入81篇文章进行数据提取。纳入的研究通过自我报告数量/频率问卷评估酒精使用情况,确定有风险的单次饮酒的标准,经过验证的筛选工具,或结构化的临床和诊断访谈。最广泛使用的筛选工具是酒精使用障碍鉴定测试。研究以各种方式定义了饮酒问题,包括过量/大量饮酒,暴饮暴食,酒精使用障碍,酗酒和酒精依赖。在整个研究中,大量饮酒的患病率从<1.0%到53.0%不等,暴饮暴食从2.7%上升到48.2%,酒精滥用从4.0%到19.0%,酒精依赖从0.1%到39.0%,酒精使用障碍从2.0%到66.6%。与饮酒问题相关的因素在不同的研究中有所不同。这些包括社会人口和经济因素(年龄,性别,关系状态,教育,employment,收入水平,宗教,种族,位置和酒精出口密度)和临床因素(如医疗问题,精神障碍,其他物质的使用和生活质量)。
    结论:由于测量的差异,研究设计和评估风险因素,问题饮酒的患病率和相关因素在研究和环境中差异很大.酒精领域将受益于酒精使用和问题饮酒的统一测量,因为这将允许在各国之间进行比较并进行荟萃分析。
    背景:开放科学框架ID:https://osf.io/2anj3。
    BACKGROUND: The term \"problem drinking\" includes a spectrum of alcohol problems ranging from excessive or heavy drinking to alcohol use disorder. Problem drinking is a leading risk factor for death and disability globally. It has been measured and conceptualised in different ways, which has made it difficult to identify common risk factors for problem alcohol use. This scoping review aims to synthesise what is known about the assessment of problem drinking, its magnitude and associated factors.
    METHODS: Four databases (PubMed, Embase, PsycINFO, Global Index Medicus) and Google Scholar were searched from inception to 25 November 2023. Studies were eligible if they focused on people aged 15 and above, were population-based studies reporting problem alcohol use and published in the English language. This review was reported based on guidelines from the \'Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews Checklist\'. Critical appraisal was done using the Newcastle-Ottawa Scale.
    RESULTS: From the 14 296 records identified, 10 749 underwent title/abstract screening, of which 352 full-text articles were assessed, and 81 articles were included for data extraction. Included studies assessed alcohol use with self-report quantity/frequency questionnaires, criteria to determine risky single occasion drinking, validated screening tools, or structured clinical and diagnostic interviews. The most widely used screening tool was the Alcohol Use Disorder Identification Test. Studies defined problem drinking in various ways, including excessive/heavy drinking, binge drinking, alcohol use disorder, alcohol abuse and alcohol dependence. Across studies, the prevalence of heavy drinking ranged from <1.0% to 53.0%, binge drinking from 2.7% to 48.2%, alcohol abuse from 4.0% to 19.0%, alcohol dependence from 0.1% to 39.0% and alcohol use disorder from 2.0% to 66.6%. Factors associated with problem drinking varied across studies. These included sociodemographic and economic factors (age, sex, relationship status, education, employment, income level, religion, race, location and alcohol outlet density) and clinical factors (like medical problems, mental disorders, other substance use and quality of life).
    CONCLUSIONS: Due to differences in measurement, study designs and assessed risk factors, the prevalence of and factors associated with problem drinking varied widely across studies and settings. The alcohol field would benefit from harmonised measurements of alcohol use and problem drinking as this would allow for comparisons to be made across countries and for meta-analyses to be conducted.
    BACKGROUND: Open Science Framework ID: https://osf.io/2anj3.
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  • 文章类型: Journal Article
    OBJECTIVE: Unconventional oil and gas development (UOGD, sometimes termed \"fracking\" or \"hydraulic fracturing\") is an industrial process to extract methane gas and/or oil deposits. Many chemicals used in UOGD have known adverse human health effects. Canada is a major producer of UOGD-derived gas with wells frequently located in and around rural and Indigenous communities. Our objective was to conduct a scoping review to identify the extent of research evidence assessing UOGD exposure-related health impacts, with an additional focus on Canadian studies.
    METHODS: We included English- or French-language peer-reviewed epidemiologic studies (January 2000-December 2022) which measured exposure to UOGD chemicals directly or by proxy, and where health outcomes were plausibly caused by UOGD-related chemical exposure. Results synthesis was descriptive with results ordered by outcome and hierarchy of methodological approach.
    RESULTS: We identified 52 studies from nine jurisdictions. Only two were set in Canada. A majority (n = 27) used retrospective cohort and case-control designs. Almost half (n = 24) focused on birth outcomes, with a majority (n = 22) reporting one or more significant adverse associations of UOGD exposure with: low birthweight; small for gestational age; preterm birth; and one or more birth defects. Other studies identified adverse impacts including asthma (n = 7), respiratory (n = 13), cardiovascular (n = 6), childhood acute lymphocytic leukemia (n = 2), and all-cause mortality (n = 4).
    CONCLUSIONS: There is a growing body of research, across different jurisdictions, reporting associations of UOGD with adverse health outcomes. Despite the rapid growth of UOGD, which is often located in remote, rural, and Indigenous communities, Canadian research on its effects on human health is remarkably sparse. There is a pressing need for additional evidence.
    RéSUMé: OBJECTIF: L’exploitation pétrolière et gazière non conventionnelle (EPGNC, parfois appelée « fracturation » ou « fracturation hydraulique ») est un processus industriel d’extraction du méthane et/ou de gisements de pétrole. De nombreux produits chimiques utilisés dans l’EPGNC ont des effets indésirables connus sur la santé humaine. Le Canada est un grand producteur de gaz dérivé de l’EPGNC, dont les puits sont souvent situés à l’intérieur et autour de communautés rurales et autochtones. Nous avons mené une étude de champ pour déterminer l’étendue des données de recherche évaluant les effets sur la santé de l’exposition à l’EPGNC, en nous concentrant plus particulièrement sur les études canadiennes. MéTHODE: Nous avons inclus des études épidémiologiques en anglais ou en français évaluées par les pairs (janvier 2000 à décembre 2022) qui mesuraient l’exposition directe ou indirecte aux produits chimiques de l’EPGNC et dans lesquelles les résultats cliniques étaient plausiblement causés par l’exposition aux produits chimiques liés à l’EPGNC. La synthèse des résultats est descriptive, et les résultats sont ordonnés selon les résultats cliniques et l’approche méthodologique. SYNTHèSE: Nous avons identifié 52 études menées dans neuf juridictions. Deux seulement étaient canadiennes. La majorité (n = 27) faisaient appel à des cohortes rétrospectives ou étaient des études cas-témoins. Près de la moitié (n = 24) portaient sur les issues de la grossesse, et la majorité (n = 22) déclaraient une ou plusieurs associations indésirables significatives entre l’exposition à l’EPGNC et : l’insuffisance de poids à la naissance; la petite taille du bébé pour son âge gestationnel; la naissance avant terme; et une ou plusieurs anomalies congénitales. D’autres études faisaient état d’effets indésirables, dont l’asthme (n = 7), les troubles respiratoires (n = 13), les troubles cardiovasculaires (n = 6), la leucémie aiguë lymphoblastique infantile (n = 2) et la mortalité toutes causes confondues (n = 4). CONCLUSION: Il existe dans différents pays un corpus croissant d’études qui font état d’associations entre l’EPGNC et des résultats sanitaires indésirables. Malgré la croissance rapide de l’EPGNC, souvent présente dans des communautés éloignées, rurales et autochtones, la recherche canadienne sur ses effets sur la santé humaine est remarquablement clairsemée. Il y a un besoin urgent de recueillir d’autres données probantes à ce sujet.
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