PDF(Pubmed)
Abstract：
BACKGROUND: Maternal-child health suggests the critical impact of maternal nutrition during the pre-conception and gestational periods, with some genetic variants also playing a significant role. Our systematic review provides an overview of epidemiological studies exploring the interactions between genetic variants, maternal dietary habits, and neonatal and/or maternal pregnancy outcomes.
METHODS: From its inception until June 2023, we conducted a comprehensive literature search on PubMed, Embase, and Web of Science databases.
RESULTS: On a total of 29 epidemiological studies, 11 studies were conducted to explore the interplay between genetic variants and dietary factors, focusing on the risks associated with gestational diabetes mellitus, hypertensive disorders of pregnancy, recurrent spontaneous abortion, recurrent pregnancy loss, iron deficiency anemia, and gestational weight gain. Concerning neonatal outcomes, six studies investigated the interplay between genetic variants, dietary factors, and anthropometric measures, while eight studies delved into abnormal embryonic development, two studies focused on preterm birth, and two studies explored other neonatal outcomes.
CONCLUSIONS: Deeply understanding gene-diet interactions could be useful in developing highly personalized approaches to maternal and child nutrition, as well as in exploring the potential implications in disease prevention and the promotion of the long-term well-being of both mothers and their offspring.
METHODS: From its inception until June 2023, we conducted a comprehensive literature search on PubMed, Embase, and Web of Science databases.
RESULTS: On a total of 29 epidemiological studies, 11 studies were conducted to explore the interplay between genetic variants and dietary factors, focusing on the risks associated with gestational diabetes mellitus, hypertensive disorders of pregnancy, recurrent spontaneous abortion, recurrent pregnancy loss, iron deficiency anemia, and gestational weight gain. Concerning neonatal outcomes, six studies investigated the interplay between genetic variants, dietary factors, and anthropometric measures, while eight studies delved into abnormal embryonic development, two studies focused on preterm birth, and two studies explored other neonatal outcomes.
CONCLUSIONS: Deeply understanding gene-diet interactions could be useful in developing highly personalized approaches to maternal and child nutrition, as well as in exploring the potential implications in disease prevention and the promotion of the long-term well-being of both mothers and their offspring.
摘要：
背景：母婴健康表明，在孕前和妊娠期，产妇营养的关键影响，一些遗传变异也起着重要作用。我们的系统评价概述了流行病学研究，探索遗传变异之间的相互作用，母亲的饮食习惯，和新生儿和/或产妇妊娠结局。
方法：从成立到2023年6月，我们对PubMed进行了全面的文献检索，Embase,和WebofScience数据库。
结果：在总共29项流行病学研究中，进行了11项研究，以探索遗传变异与饮食因素之间的相互作用，关注与妊娠糖尿病相关的风险，妊娠高血压疾病，复发性自然流产,反复妊娠丢失,缺铁性贫血,和妊娠期体重增加。关于新生儿结局，六项研究调查了遗传变异之间的相互作用，饮食因素，和人体测量，虽然有8项研究深入研究胚胎发育异常，两项针对早产的研究,两项研究探讨了其他新生儿结局。
结论：深入了解基因-饮食相互作用可能有助于开发高度个性化的母婴营养方法，以及探索疾病预防和促进母亲及其后代长期福祉的潜在影响。
方法：从成立到2023年6月，我们对PubMed进行了全面的文献检索，Embase,和WebofScience数据库。
结果：在总共29项流行病学研究中，进行了11项研究，以探索遗传变异与饮食因素之间的相互作用，关注与妊娠糖尿病相关的风险，妊娠高血压疾病，复发性自然流产,反复妊娠丢失,缺铁性贫血,和妊娠期体重增加。关于新生儿结局，六项研究调查了遗传变异之间的相互作用，饮食因素，和人体测量，虽然有8项研究深入研究胚胎发育异常，两项针对早产的研究,两项研究探讨了其他新生儿结局。
结论：深入了解基因-饮食相互作用可能有助于开发高度个性化的母婴营养方法，以及探索疾病预防和促进母亲及其后代长期福祉的潜在影响。
