Nanoliposomal formulations, utilizing lipid bilayers to encapsulate therapeutic agents, hold promise for targeted drug delivery. Recent studies have explored the application of machine learning (ML) techniques in this field. This study aims to elucidate the motivations behind integrating ML into liposomal formulations, providing a nuanced understanding of its applications and highlighting potential advantages. The review begins with an overview of liposomal formulations and their role in targeted drug delivery. It then systematically progresses through current research on ML in this area, discussing the principles guiding ML adaptation for liposomal preparation and characterization. Additionally, the review proposes a conceptual model for effective ML incorporation. The review explores popular ML techniques, including ensemble learning, decision trees, instance- based learning, and neural networks. It discusses feature extraction and selection, emphasizing the influence of dataset nature and ML method choice on technique relevance. The review underscores the importance of supervised learning models for structured liposomal formulations, where labeled data is essential. It acknowledges the merits of K-fold cross-validation but notes the prevalent use of single train/test splits in liposomal formulation studies. This practice facilitates the visualization of results through 3D plots for practical interpretation. While highlighting the mean absolute error as a crucial metric, the review emphasizes consistency between predicted and actual values. It clearly demonstrates ML techniques\' effectiveness in optimizing critical formulation parameters such as encapsulation efficiency, particle size, drug loading efficiency, polydispersity index, and liposomal flux. In conclusion, the review navigates the nuances of various ML algorithms, illustrating ML\'s role as a decision support system for liposomal formulation development. It proposes a structured framework involving experimentation, physicochemical analysis, and iterative ML model refinement through human-centered evaluation, guiding future studies. Emphasizing meticulous experimentation, interdisciplinary collaboration, and continuous validation, the review advocates seamless ML integration into liposomal drug delivery research for robust advancements. Future endeavors are encouraged to uphold these principles.

Numerous efforts and research have been conducted worldwide to combat the coronavirus disease 2019 (COVID-19) pandemic. In this regard, some researchers have focused on deep and machine-learning approaches to discover more about this disease. There have been many articles on using ensemble learning methods for COVID-19 detection. Still, there seems to be no scientometric analysis or a brief review of these researches. Hence, a combined method of scientometric analysis and brief review was used to study the published articles that employed an ensemble learning approach to detect COVID-19. This research used both methods to overcome their limitations, leading to enhanced and reliable outcomes. The related articles were retrieved from the Scopus database. Then a two-step procedure was employed. A concise review of the collected articles was conducted. Then they underwent scientometric and bibliometric analyses. The findings revealed that convolutional neural network (CNN) is the mostly employed algorithm, while support vector machine (SVM), random forest, Resnet, DenseNet, and visual geometry group (VGG) were also frequently used. Additionally, China has had a significant presence in the numerous top-ranking categories of this field of research. Both study phases yielded valuable results and rankings.

BACKGROUND: Lung diseases, both infectious and non-infectious, are the most prevalent cause of mortality overall in the world. Medical research has identified pneumonia, lung cancer, and Corona Virus Disease 2019 (COVID-19) as prominent lung diseases prioritized over others. Imaging modalities, including X-rays, computer tomography (CT) scans, magnetic resonance imaging (MRIs), positron emission tomography (PET) scans, and others, are primarily employed in medical assessments because they provide computed data that can be utilized as input datasets for computer-assisted diagnostic systems. Imaging datasets are used to develop and evaluate machine learning (ML) methods to analyze and predict prominent lung diseases.
OBJECTIVE: This review analyzes ML paradigms, imaging modalities\' utilization, and recent developments for prominent lung diseases. Furthermore, the research also explores various datasets available publically that are being used for prominent lung diseases.
METHODS: The well-known databases of academic studies that have been subjected to peer review, namely ScienceDirect, arXiv, IEEE Xplore, MDPI, and many more, were used for the search of relevant articles. Applied keywords and combinations used to search procedures with primary considerations for review, such as pneumonia, lung cancer, COVID-19, various imaging modalities, ML, convolutional neural networks (CNNs), transfer learning, and ensemble learning.
RESULTS: This research finding indicates that X-ray datasets are preferred for detecting pneumonia, while CT scan datasets are predominantly favored for detecting lung cancer. Furthermore, in COVID-19 detection, X-ray datasets are prioritized over CT scan datasets. The analysis reveals that X-rays and CT scans have surpassed all other imaging techniques. It has been observed that using CNNs yields a high degree of accuracy and practicability in identifying prominent lung diseases. Transfer learning and ensemble learning are complementary techniques to CNNs to facilitate analysis. Furthermore, accuracy is the most favored metric for assessment.

Mobile app stores, such as Google Play, have become famous platforms for practically all types of software and services for mobile phone users. Users may browse and download apps via app stores, which also help developers monitor their apps by allowing users to rate and review them. App reviews may contain the user\'s experience, bug details, requests for additional features, or a textual rating of the app. These ratings can be frequently biased due to inadequate votes. However, there are significant discrepancies between the numerical ratings and the user reviews. This study uses a transfer learning approach to predict the numerical ratings of Google apps. It benefits from user-provided numeric ratings of apps as the training data and provides authentic ratings of mobile apps by analyzing users\' reviews. A transfer learning-based model ELMo is proposed for this purpose which is based on the word vector feature representation technique. The performance of the proposed model is compared with three other transfer learning and five machine learning models. The dataset is scrapped from the Google Play store which extracts the data from 14 different categories of apps. First, biased and unbiased user rating is segregated using TextBlob analysis to formulate the ground truth, and then classifiers prediction accuracy is evaluated. Results demonstrate that the ELMo classifier has a high potential to predict authentic numeric ratings with user actual reviews.

Accurately and rapidly distinguishing long noncoding RNAs (lncRNAs) from transcripts is prerequisite for exploring their biological functions. In recent years, many computational methods have been developed to predict lncRNAs from transcripts, but there is no systematic review on these computational methods. In this review, we introduce databases and features involved in the development of computational prediction models, and subsequently summarize existing state-of-the-art computational methods, including methods based on binary classifiers, deep learning and ensemble learning. However, a user-friendly way of employing existing state-of-the-art computational methods is in demand. Therefore, we develop a Python package ezLncPred, which provides a pragmatic command line implementation to utilize nine state-of-the-art lncRNA prediction methods. Finally, we discuss challenges of lncRNA prediction and future directions.

Anti-cancer peptides (ACPs) are known as potential therapeutics for cancer. Due to their unique ability to target cancer cells without affecting healthy cells directly, they have been extensively studied. Many peptide-based drugs are currently evaluated in the preclinical and clinical trials. Accurate identification of ACPs has received considerable attention in recent years; as such, a number of machine learning-based methods for in silico identification of ACPs have been developed. These methods promote the research on the mechanism of ACPs therapeutics against cancer to some extent. There is a vast difference in these methods in terms of their training/testing datasets, machine learning algorithms, feature encoding schemes, feature selection methods and evaluation strategies used. Therefore, it is desirable to summarize the advantages and disadvantages of the existing methods, provide useful insights and suggestions for the development and improvement of novel computational tools to characterize and identify ACPs. With this in mind, we firstly comprehensively investigate 16 state-of-the-art predictors for ACPs in terms of their core algorithms, feature encoding schemes, performance evaluation metrics and webserver/software usability. Then, comprehensive performance assessment is conducted to evaluate the robustness and scalability of the existing predictors using a well-prepared benchmark dataset. We provide potential strategies for the model performance improvement. Moreover, we propose a novel ensemble learning framework, termed ACPredStackL, for the accurate identification of ACPs. ACPredStackL is developed based on the stacking ensemble strategy combined with SVM, Naïve Bayesian, lightGBM and KNN. Empirical benchmarking experiments against the state-of-the-art methods demonstrate that ACPredStackL achieves a comparative performance for predicting ACPs. The webserver and source code of ACPredStackL is freely available at http://bigdata.biocie.cn/ACPredStackL/ and https://github.com/liangxiaoq/ACPredStackL, respectively.

The process of segmenting tumor from MRI image of a brain is one of the highly focused areas in the community of medical science as MRI is noninvasive imaging. This paper discusses a thorough literature review of recent methods of brain tumor segmentation from brain MRI images. It includes the performance and quantitative analysis of state-of-the-art methods. Different methods of image segmentation are briefly explained with the recent contribution of various researchers. Here, an effort is made to open new dimensions for readers to explore the concerned area of research. Through the entire review process, it has been observed that the combination of Conditional Random Field (CRF) with Fully Convolutional Neural Network (FCNN) and CRF with DeepMedic or Ensemble are more effective for the segmentation of tumor from the brain MRI images.

The majority of the human genome consists of non-coding regions that have been called junk DNA. However, recent studies have unveiled that these regions contain cis-regulatory elements, such as promoters, enhancers, silencers, insulators, etc. These regulatory elements can play crucial roles in controlling gene expressions in specific cell types, conditions, and developmental stages. Disruption to these regions could contribute to phenotype changes. Precisely identifying regulatory elements is key to deciphering the mechanisms underlying transcriptional regulation. Cis-regulatory events are complex processes that involve chromatin accessibility, transcription factor binding, DNA methylation, histone modifications, and the interactions between them. The development of next-generation sequencing techniques has allowed us to capture these genomic features in depth. Applied analysis of genome sequences for clinical genetics has increased the urgency for detecting these regions. However, the complexity of cis-regulatory events and the deluge of sequencing data require accurate and efficient computational approaches, in particular, machine learning techniques. In this review, we describe machine learning approaches for predicting transcription factor binding sites, enhancers, and promoters, primarily driven by next-generation sequencing data. Data sources are provided in order to facilitate testing of novel methods. The purpose of this review is to attract computational experts and data scientists to advance this field.