Endovascular embolization

血管内栓塞
  • 文章类型: Case Reports
    Galen动脉瘤性静脉畸形是一种罕见的先天性脑血管畸形。这是胚胎血管持续存在的结果,导致多个动静脉分流。这种畸形可引起多种症状,从心力衰竭到头痛,具体取决于就诊年龄。在胎儿中,心脏表现很少见,并且与非常差的预后有关。这就是为什么产前诊断在早期发现和管理中至关重要。我们介绍一例Galen动脉瘤畸形的静脉,产前超声诊断。新生儿广泛发展为高输出心力衰竭。产前诊断有助于早期发现这种畸形并预测预后。
    The vein of Galen aneurysmal malformation is a rare congenital malformation of the cerebral blood vessels. It is a result of the persistence of an embryonic vessel that drains multiple arteriovenous shunts. This malformation can cause a multitude of symptoms ranging from cardiac failure to headaches depending on the age of presentation. In the fetus, cardiac manifestations are rare and are linked to a very poor prognosis. That\'s why prenatal diagnosis is crucial in early detection and management. We present a case of a vein of Galen aneurysmal malformation, diagnosed prenatally with ultrasonography. The newborn developed widely a high-output cardiac failure. Prenatal diagnosis facilitates the early detection of this malformation as well as predicting the prognosis.
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  • 文章类型: Case Reports
    鼻咽血管纤维瘤(NA)是一种相对罕见的,非癌,极度血管性肿瘤,它只在男性身上发现。NA从各种来源接受血液供应,并在手术切除后可能导致大量失血。如今,血管内栓塞有可能减少术中出血和降低复发率。本病例系列旨在描述鼻咽血管纤维瘤的术前血管内栓塞。在这项研究中,我们报告了3例青少年NA的CT血管造影诊断。所有受试者都有一个成功的栓塞,这导致最小的术后出血和良好的结果。
    Nasopharyngeal angiofibroma (NA) is a relatively rare, noncancerous, extremely vascular tumor, and it is only found in males. NA receives blood supply from various sources and can lead to major blood loss after surgical excision. Nowadays, endovascular embolization has the potential to reduce intraoperative bleeding and lower the recurrence rate. This case series aimed to describe the preoperative endovascular embolization of nasopharyngeal angiofibroma. In this study, we reported 3 cases of adolescents with NA diagnosed using CT angiography. All subjects had a successful embolization, which led to minimal postoperative bleeding and good outcome.
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  • 文章类型: Case Reports
    当治疗需要非手术治疗的肝脏巨大海绵状血管瘤患者时,经导管动脉栓塞术已被证明是一种有效的技术。与手术相比,显着的优势包括消除这些病变的血管供应的能力以及微创性。一名65岁的妇女来到我们医院,主要抱怨胃痛已经持续了六个月。在临床检查中,患者在右侧软骨下有一个硬块。超声波显示,定义明确,具有中央坏死区的异质性病变,肝实质的其余部分在门静脉中具有正常的回声结构和流量。这位65岁的妇女到达我们医院时的主要抱怨是胃痛,已经存在了六个月。肝功能检查结果正常。在推定鉴定出明显的肝血管瘤后,患者被带到血管造影和适当的肝动脉栓塞术。考虑到病人的年龄,病变的严重程度,和它的高度血管特性,使用脂肪醇和博来霉素进行适当肝动脉的血管内栓塞。病人住院两天后出院,服用抗生素,建议15天后跟进。栓塞后肝功能正常。患者在三个月的随访后没有症状。因此,用脂质体和博来霉素进行血管内栓塞是一种安全有效的方法,防止灾难性的出血,并为患者提供症状缓解。
    When treating patients with a massive cavernous hemangioma of the liver that requires nonsurgical therapy, transcatheter arterial embolization has proven to be an effective technique. Significant advantages include the ability to obliterate the vascular supply of these lesions and the minimally invasive nature compared to surgery. A 65-year-old woman arrived at our hospital complaining primarily of stomach pain that had been there for six months. The patient had a hard lump in the right hypochondrium on clinical examination. Ultrasound showed a large, well-defined, heterogeneous lesion with central necrotic areas, with the rest of the liver parenchyma having normal echotexture and flow in the portal vein. The 65-year-old woman\'s primary complaint upon arrival at our hospital was a stomach ache that had been there for six months. The results of the liver function test were normal. Upon presumptive identification of a significant hepatic hemangioma, the patient was brought to the angio-suite for angiography and proper hepatic artery embolization. Considering the patient\'s age, the severity of the lesion, and its highly vascular character, endovascular embolization of the proper hepatic artery using lipidol and bleomycin was performed. The patient was discharged after two days in the hospital, administered antibiotics, and advised to follow up after 15 days. Liver function after embolization was within normal limits. The patient had no symptoms after a follow-up at three months. Therefore, endovascular embolization with lipidol and bleomycin is a safe and effective method to obliterate the vascular supply to the lesion, prevent catastrophic bleeding, and provide symptomatic relief to the patient.
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  • 文章类型: Journal Article
    目的:确定脑动静脉畸形(rBAVM)破裂患者是否会从早期栓塞中获益。
    方法:rBAVM首先在2002年3月至2022年5月之间通过栓塞治疗。当在出血后10天内进行时,早期定义为栓塞(第1组)。如果以后,栓塞被认为是晚期(第2组)。比较两组人口统计学和rBAVM数据。检索了高危出血成分和推迟栓塞的原因。主要终点为再出血。次要终点是良好的功能结果(FO,改良Rankin量表mRS≤2)和血管造影闭塞。通过多变量分析确定再出血和FO的预测因子。
    结果:招募了105名患者(第1组N=34;第2组N=71)。之前没有发现再出血,在早期栓塞组的第一次栓塞期间或之后。晚期栓塞取决于漏诊和转诊方式。11名患者(10.5%)出现了再出血,其中在栓塞前N=3(仅在第2组中),N=5周栓塞(第1组第二次栓塞时N=2),栓塞后30天以上自发N=3。第1组栓塞了更多的高危成分(19/34;55.9vs17/71;23.9%;p=.011)。再出血率,末次FU的FO(90.9%vs74.3%)和闭塞率(80.8%vs88.5%)在组间没有差异。格拉斯哥昏迷评分≤8预测再出血,再出血与FO不良相关。
    结论:早期栓塞确实可以预防再出血。总体再出血风险与晚期栓塞前出血和第二次栓塞时出血有关。再出血预测了最终的FO。
    OBJECTIVE: To determine whether patients with a ruptured brain arteriovenous malformation (rBAVM) would benefit from an early embolization.
    METHODS: rBAVM treated first by embolization between March 2002 and May 2022 were included. Embolization was defined early (Group 1) when performed within 10 days postbleeding. If later, embolization was considered late (Group 2). Demographic and rBAVM data were compared between the groups. High-risk bleeding components and reasons for deferring embolization were retrieved. Primary endpoint was rebleeding. Secondary endpoints were good functional outcome (FO, modified Rankin Scale mRS ≤ 2) and angiographic occlusion. Predictors of rebleeding and FO were determined by multivariate analysis.
    RESULTS: 105 patients were recruited (N = 34 in Group 1; N = 71 in Group 2). No rebleeding was noted before, during or after the first embolization session in the early embolization group. Late embolization depended on missed diagnosis and referral pattern. Eleven patients (10.5%) suffered a rebleeding, of whom N = 3 before embolization (only in Group 2), N = 5 periembolization (N = 2 at the second embolization session in Group 1) and N = 3 spontaneous more than 30 days postembolization. More high-risk components were embolized in Group 1 (19/34; 55.9 vs 17/71; 23.9%; p = .011). Rebleeding rates, FO at last FU (90.9% vs 74.3%) and occlusion rates (80.8% vs 88.5%) did not differ between the groups. Glasgow coma scale ≤ 8 predicted rebleeding, rebleeding correlated with poor FO.
    CONCLUSIONS: Early embolization did prevent rebleeding. The overall rebleeding risk was linked to bleeding before late embolization and bleeding at the second embolization. Rebleeding predicted the final FO.
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  • 文章类型: Journal Article
    关于颅内动脉瘤治疗,在巴西,剪辑与线圈的争论仍然没有定论,缺乏研究。随着时间的推移,研究巴西颅内动脉瘤的治疗趋势,破裂和未破裂。使用巴西公共卫生系统数据库(DATASUS),根据动脉瘤治疗的神经血管程序数据进行了描述性和探索性研究。分析的变量是程序的数量,死亡率,住院时间,和全球住院费用,从2010年到2019年。进行时间趋势分析和统计比较以评估随时间的变化和治疗方案之间的差异。年平均血管内栓塞动脉瘤治疗次数为2206.30(±309.5),增加趋势不显著(B=55.66;p=0.104)。相反,显微手术夹闭显示出显着下降趋势(B=-69.97;p<0.001),平均为1133.1(±223.12)。在此期间,与剪裁程序相关的死亡率较高,平均差为5.23(±0.39);([CI95%:4.36;6.10];p<0.001),呈增加趋势,而栓塞表现出稳定的趋势。住院时间因夹闭而保持稳定,但因栓塞而增加。与剪裁相关的成本随着时间的推移而增加,而栓塞费用下降。这项研究强调了动脉瘤治疗向血管内栓塞的重大转变。尽管成本较高,血管内手术与较低的死亡率和较短的住院时间相关.这些发现为中等收入国家公共卫生系统中的动脉瘤治疗模式和指标提供了有价值的见解。
    Regarding intracranial aneurysm treatment, the clip versus coil debate remains inconclusive and lacking studies in Brazil. To examine trends in the management of intracranial aneurysms in Brazil over time, both ruptured and unruptured. A descriptive and exploratory study was conducted based on data of neurovascular procedures for aneurysm treatment using the Brazilian Public Health System database (DATASUS). The variables analyzed were the number of procedures, mortality rates, length of hospital stays, and global costs of hospitalization, from 2010 to 2019. Temporal trend analysis and statistical comparisons were conducted to assess changes over time and differences between the treatment options. The mean annual number of aneurysm treatments with endovascular embolization was 2206.30 (± 309.5), with a non-significant increasing trend (B = 55.66; p = 0.104). Conversely, microsurgical clipping exhibited a significant decreasing trend (B = -69.97; p < 0.001) with a mean of 1133.1 (± 223.12) procedures. The mortality rate associated with clipping procedure was higher in the period, with a mean difference of 5.23 (± 0.39); ([CI95%: 4.36; 6.10]; p < 0.001) and showed an increase trend, while embolization showed a stable trend. The length of in-hospital stay remained stable for clipping but increased for embolization. Costs associated with clipping increased over time, whereas costs for embolization decreased. This study highlights a significant shift in the treatment of aneurysm towards Endovascular Embolization. Despite higher costs, endovascular procedures were associated with lower mortality rates and shorter hospital stays. These findings provide valuable insights into aneurysm treatment patterns and indicators in a middle-income country\'s Public Health System.
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  • 文章类型: Case Reports
    脑动静脉畸形(AVM)是一种罕见的先天性疾病,影响年轻人,每100,000人口中发病率为0.94。必须对所有患者进行颅内数字减影血管造影,并根据Spetzler-Martin分级进行AVM分级。我们报告了罕见的左基底节大AVM经血管内栓塞治疗。我们使用Onyx进行血管内栓塞的经验在治疗大脑AVM方面是成功的。Onyx的血管内栓塞在深部大的大脑AVM中是安全可行的。我们的患者术后完全康复,没有任何神经功能缺损。
    Brain arteriovenous malformation (AVM) is a rare congenital disorder affecting young adults with an incidence of 0.94 per 100,000 population. Intracranial digital subtraction angiography has to be done in all patients and grading of AVM is done as per Spetzler-Martin grading. We report a rare case of left basal ganglia large AVM treated by endovascular embolization. Our experience with endovascular embolization using Onyx is successful in the treatment of large brain AVM. Endovascular embolization with Onyx is safe and feasible in deeply located large AVMs of the brain. Our patient has postoperatively recovered completely without any neurological deficit.
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  • 文章类型: Case Reports
    在通过传统的经皮方法无法进入所涉及的静脉窦段的情况下,高级硬脑膜动静脉瘘(dAVF)的最佳血管内管理在技术上具有挑战性。在这份报告中,我们描述了经颅血管内入路治疗高级别dAVF的经验.我们还提供了经颅血管内dAVF栓塞的其他报道的文献综述。我们建议,在仅经皮途径无法进入瘘管的情况下,高等级dAVF的经颅血管内栓塞似乎是安全有效的。
    The optimal endovascular management of high-grade dural arterial-venous fistulae (dAVF) can be technically challenging in cases where the involved venous sinus segment is inaccessible through the traditional percutaneous approach. In this report, we describe our experience with the transcranial endovascular approach for the treatment of a high-grade dAVF. We also provide a literature review of other reports of transcranial endovascular dAVF embolization. We propose that transcranial endovascular embolization of high-grade dAVF appears to be safe and effective in cases where the fistula is inaccessible to percutaneous routes alone.
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  • 文章类型: Case Reports
    Galen静脉畸形(VOGM)是一种罕见的先天性动静脉畸形,影响儿科人群,特征是间脑和Galen扩张静脉之间的瘘管。本研究报告了一例因发育迟缓和头围异常而转诊的6个月大男婴。临床检查显示大头畸形,扩张的头皮静脉和神经系统异常。神经影像学检查证实了大的VOGM与相关的脑积水。一个多学科小组制定了涉及血管内栓塞和脑室腹膜分流术的治疗计划。术后恢复表现出神经发育里程碑的改善和头围的减少。一般来说,VOGM的管理需要一个全面的方法,包括早期诊断,精确的成像和及时的干预。本文描述的病例强调了介入放射学在计划管理计划和新型接吻微导管血管内栓塞技术中的重要性。
    Vein of Galen malformation (VOGM) is a rare congenital arteriovenous malformation affecting the pediatric population, characterized by a fistula between the diencephalon and a dilated vein of Galen. The present study reports the case of a 6-month-old male infant referred for developmental delays and abnormal head circumference. A clinical examination revealed macrocephaly, dilated scalp veins and neurological abnormalities. Neuroimaging confirmed a large VOGM with associated hydrocephalus. A multidisciplinary team devised a treatment plan involving endovascular embolization and ventriculoperitoneal shunt placement. The post-operative recovery exhibited an improvement in neurodevelopmental milestones and a reduced head circumference. Generally, the management of VOGM requires a comprehensive approach, including early diagnosis, precise imaging and timely intervention. The case described herein highlights the importance of interventional radiology in planning a management plan and the novel kissing microcatheter endovascular embolization technique.
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  • 文章类型: Journal Article
    目的:描述通过使用液体栓塞剂的经动脉栓塞技术通过血管内栓塞治疗颅内硬脑膜动静脉瘘(DAVF)的经验。我们说明了在复杂的DAVF中使用双动脉通道进行血管造影控制的技术细微差别,该DAVF由来自两个不同动脉系统的多个进料器提供。
    方法:回顾性分析2013-2023年在我们机构作为单一治疗技术的颅内DAVF栓塞。
    结果:纳入了23例接受血管内治疗作为初始治疗的颅内DAVF患者。所有栓塞均通过Onyx(n=19)经动脉(TAE)进行,NBCA(n=2),或组合(n=2)。96%(n=22)的患者在初次栓塞后有血管造影证据表明瘘管完全闭塞。通过双动脉通路进行了六个DAVFTAE,在术中同时进行栓塞输送和血管造影控制。两名患者(2/22)术后两次再通,其中一名患者在随访中发现偶然出现了新的DAVF。中位患者随访时间为12个月(IQR:6-36),出院时的中位mRS为1,GOS为3个月5。
    结论:在这一系列最初的DAVF患者中,通过血管内栓塞治疗,作者发现双动脉通路是可行的,安全,并有效实现瘘管消除。双动脉通路方便地提供了用于控制血管造影术和在手术中体现递送的同时通路。
    BACKGROUND: Here we describe our experience managing intracranial dural arteriovenous fistulas (DAVFs) via endovascular embolization using a transarterial embolization (TAE) technique with liquid embolic agents. We illustrate the technical nuance of using dual arterial access for angiographic control runs in complex DAVFs supplied by multiple feeders from 2 distinct arterial systems.
    METHODS: Retrospective analysis of intracranial DAVF embolization as a single treatment technique at our institution from 2013 to 2023.
    RESULTS: Twenty-three patients with intracranial DAVF who underwent endovascular treatment as their initial treatment were included. All embolizations were approached transarterially with Onyx (n = 19), n-butyl cyanoacrylate (n = 2), or a combination (n = 2). Twenty-two patients (96%) had angiographic evidence of complete fistula obliteration after initial embolization. Six DAVF TAEs were performed with dual arterial access for simultaneous embolic delivery and angiographic control intraoperatively. Two patients recanalized twice postprocedure, 1 of whom was found to have incidental new DAVF at follow-up. Median patient follow-up was 12 months (interquartile range, 6-36 months), with a median modified Rankin Scale score on discharge of 1 and a Glasgow Outcome Scale score at 3 months of 5.
    CONCLUSIONS: In this initial series of patients with DAVF managed by endovascular embolization, dual arterial access was feasible, safe, and effective in achieving fistula obliteration. Dual-arterial access conveniently provides simultaneous access for control angiography and embosylate delivery intraoperatively.
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  • 文章类型: Journal Article
    背景:颅内动脉瘤在儿童年龄组中很少见,尤其是新生儿。本文介绍了一个新的病例,新生儿解剖并破裂的巨大大脑前动脉瘤,重点是诊断和血管内治疗,并回顾文献。
    方法:一名足月女性新生儿出现抛射性呕吐,发烧,和运动过度运动。诊断检查显示,沿着大脑前动脉有一个巨大的解剖和部分血栓形成的动脉瘤。新生儿接受了成功的血管内线圈栓塞。
    结果:干预导致症状停止,患者出院,并在9个月时出现轻度张力减退是唯一的神经功能缺损。
    结论:该病例突出了新生儿巨大解剖性大脑前动脉动脉瘤诊断和治疗的罕见性和复杂性。它强调了在具有相关症状的新生儿的鉴别诊断中考虑颅内动脉瘤的重要性,并建议血管内栓塞作为一种有效的治疗选择。
    BACKGROUND: Intracranial aneurysms are rare in the pediatric age group, especially in neonates. This article presents a novel case of a neonate with a dissected and ruptured giant anterior cerebral artery aneurysm, focusing on diagnosis and endovascular treatment with a review of the literature.
    METHODS: A full-term female neonate presented with projectile vomiting, fever, and hyperkinetic movements. Diagnostic workup revealed a giant dissecting and partially thrombosed aneurysm along the anterior cerebral artery. The neonate underwent successful endovascular coil embolization.
    RESULTS: The intervention led to the cessation of symptoms, and the patient was discharged and followed with mild hypotonia as the only neurological deficit at 9 months.
    CONCLUSIONS: This case highlights the rarity and complexity of diagnosing and treating giant dissected anterior cerebral artery aneurysms in neonates. It underscores the importance of considering intracranial aneurysms in differential diagnosis for neonates with relevant symptoms and suggests endovascular embolization as an effective treatment option.
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