在35至45岁之间,对患有卵巢癌的高遗传风险妇女进行降低风险的输卵管卵巢切除术(RRSO)。虽然有可能挽救生命,RRSO可能会引起对生活质量产生负面影响并损害长期健康的症状。RRSO后的临床护理通常是次优的。本范围审查描述了RRSO如何影响短期和长期健康,并为从术前咨询到长期疾病预防的护理提供了基于证据的国际共识建议。这包括激素和非激素治疗血管舒缩症状的疗效和安全性,睡眠障碍和性功能障碍以及预防骨骼和心血管疾病的有效方法。
Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international
consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.