香烟烟雾是化学物质的复杂混合物,包括几种烟草特有的亚硝胺(TSNA)。大多数TSNA是在采后期间在烟草中形成的,而香烟燃烧时会产生一个数字。大量证据支持TSNA在肺癌中的重要致病因素,胰腺,食道,以及使用烟草制品的人的口腔。在已知的TSNA中,尼古丁衍生的亚硝胺酮(NNK)和N-亚硝基或尼古丁(NNN)是最致癌的。其它TSNA包括N'-亚硝基那碱(NAT)和N-亚硝基那碱(NAB)。新烟草产品(例如,电子烟)旨在吸引关注烟草对健康影响的消费者已经出现在市场上。一些研究报告说,在电子烟的替代液体和蒸气中检测到某些TSNA,但其含量通常远低于烟草香烟。此外,FDA最近宣布打算监管电子烟的TSNA,雪茄烟草和烟斗烟草。随着减少烟草制品使用的新技术的兴起,如电子烟,以评估随着时间的推移对这些有害化学物质的暴露水平,由于使用这些设备,研究人员将监测体内TSNA的水平。
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period, while a number are produced when a cigarette is burned. Considerable evidence supports the role of TSNA important causative factors for cancers of the lung, pancreas, esophagus, and oral cavity in people who use tobacco products. Of the known TSNA, nicotine-derived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN) are the most carcinogenic. Other TSNA include N\'-nitrosoanatabine (NAT) and N-nitrosoanabasine (NAB). New tobacco products (e.g., e-cigarettes) designed to attract consumers who are concerned about the health effects of tobacco have been appearing on the market. Several studies have reported that certain TSNA have been detected in the replacement liquids and vapour of e-cigarettes, but the levels are generally considerably lower than in tobacco cigarettes. Additionally, the FDA recently announced its intention to regulate TSNA in e-cigarettes, cigar tobacco and pipe tobacco. With the rise of new technologies for reducing the use of tobacco products-such as e-cigarettes- to evaluate exposure levels to these harmful chemicals over time, researchers will be monitoring levels of TSNA in the body as a result of the use of these devices.