Dysphagia

吞咽困难
  • 文章类型: Journal Article
    延髓症状的表现,尤其是吞咽,对于评估脊髓性肌萎缩症(SMA)的疾病改善疗法很重要。由于缺乏仪器,该主题在研究中仍然代表性不足。
    本研究旨在开发一种工具来监测0至24个月患有SMA的儿童的吞咽发育。
    该方法以COSMIN指南为指导,并遵循多阶段Delphi过程。第一步是快速审查24个月以下SMA儿童的吞咽结果。第二步,进行了关于婴儿吞咽困难的专家(n=7)的在线小组访谈,随后是SMA婴儿专家的匿名在线调查(n=19)。名义缩放投票的预定义共识阈值设置为≥75%,5点Likert缩放投票的四分位数范围为1.25。第三步是仪器的中试,对三组进行(健康对照组n=8;症状前n=6,有症状n=6)。
    基于多层次的跨专业共识,DySMA包括两个部分(历史和检查),十类,36个项目实施和评分清晰,易于实施。初步测试表明,吞咽发育可以记录在所有组中。
    DySMA非常适合监测症状前和症状治疗的SMA婴儿的吞咽发育。它可以以时间高效和跨专业的方式进行。所得分数与测量其他域的其他仪器的结果相当,例如,运动功能。
    UNASSIGNED: The manifestation of bulbar symptoms, especially swallowing, is important for evaluating disease-modifying therapies for spinal muscular atrophy (SMA). Due to the lack of instruments, the topic is still underrepresented in research.
    UNASSIGNED: This study aimed to develop a tool to monitor swallowing development in children aged 0 to 24 months with SMA.
    UNASSIGNED: The method was guided by the COSMIN guidelines and followed a multi-stage Delphi process. The first step was a rapid review of swallowing outcomes in children with SMA younger than 24 months. In the second step, online group interviews with experts (n = 7) on dysphagia in infants were conducted, followed by an anonymous online survey among experts in infants with SMA (n = 19). A predefined consensus threshold for nominal scaled voting was set at≥75 % and for 5-point Likert scale voting at 1.25 of the interquartile range. The third step was the pilot test of the instrument, performed with three groups (healthy controls n = 8; pre-symptomatic n = 6, symptomatic n = 6).
    UNASSIGNED: Based on the multi-level interprofessional consensus, the DySMA comprises two parts (history and examination), ten categories, with 36 items. Implementation and scoring are clearly articulated and easy to implement. The pilot test showed that swallowing development could be recorded in all groups.
    UNASSIGNED: The DySMA is well suited for monitoring swallowing development in pre-symptomatic and symptomatic treated infants with SMA. It can be performed in a time-efficient and interprofessional manner. The resulting score is comparable to results from other instruments measuring other domains, e.g., motor function.
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  • 文章类型: Systematic Review
    吞咽困难是中风患者的常见并发症,广泛影响中风后的恢复和生活质量。本系统评价的目的是通过严格评估中风吞咽困难管理的临床实践指南(CPG)的质量,确定证据与实践之间的差距。
    我们在2014年1月1日至2023年8月1日之间系统地搜索了学术数据库和指南存储库。两位作者使用研究与评估指南(AGREEII)工具独立评估CPG质量。
    总共包含14个CPG,我们确定三个CPG获得了“高质量”的最终评估,“9个CPG达到了“中等质量”,2个CPG收到了“低质量”。“范围和目的”领域的平均得分最高(91.1%),中位数最高(IQR)为91.7%(86.1,94.4%),而“适用性”领域的平均得分最低(55.8%),中位数(IQR)最低为55.4%(43.2,75.5%)。
    CPG开发小组应更加注意根据AGREEII仪器提高方法学质量,特别是在“适用性”和“利益相关者参与”领域,每个项目都应该尽可能地完善。
    UNASSIGNED: Dysphagia is a common complication in stroke patients, widely affecting recovery and quality of life after stroke. The objective of this systematic review is to identify the gaps that between evidence and practice by critically assessing the quality of clinical practice guidelines (CPGs) for management of dysphagia in stroke.
    UNASSIGNED: We systematically searched academic databases and guideline repositories between January 1, 2014, and August 1, 2023. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was used by two authors to independently assess CPG quality.
    UNASSIGNED: In a total of 14 CPGs included, we identified that three CPGs obtained a final evaluation of \"high quality,\" nine CPGs achieved \"moderate quality\" and two CPGs received \"low quality.\" The domain of \"scope and purpose\" achieved the highest mean score (91.1%) and the highest median (IQR) of 91.7% (86.1, 94.4%), while the domain of \"applicability\" received the lowest mean score (55.8%) and the lowest median (IQR) of 55.4% (43.2, 75.5%).
    UNASSIGNED: The CPG development group should pay more attention to improving the methodological quality according to the AGREE II instrument, especially in the domain of \"applicability\" and \"stakeholder involvement;\" and each item should be refined as much as possible.
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  • 文章类型: Journal Article
    食管胃结合部(EGJ)流出障碍,包括贲门失弛缓症和EGJ流出梗阻,运动障碍的特征是食管下括约肌松弛不足,有或没有食管蠕动受损。目前的准则是技术性的,在亚太地区不太实用,在及时诊断和有效管理这些疾病方面仍然存在巨大挑战。因此,马来西亚联合社团特别工作组根据最新证据,就EGJ外流障碍达成了共识,同时考虑到当地和区域背景和资源的实际相关性。经过一系列会议和对文献的广泛审查,建立了21个声明。在协商一致投票过程中采用德尔菲法。这种共识集中在定义上,诊断性调查,治疗结果的目标,非手术或手术治疗选择,治疗失败或复发的管理,和并发症的管理。该共识主张使用高分辨率食管测压来诊断EGJ流出障碍。肌切开术,通过内窥镜或腹腔镜检查,是首选的治疗选择,而气动扩张可以作为一个次要的选择。建议评估和处理并发症,包括术后反流和癌症监测。
    Disorders of esophagogastric junction (EGJ) outflow, including achalasia and EGJ outflow obstruction, are motility disorders characterized by inadequate relaxation of lower esophageal sphincter with or without impaired esophageal peristalsis. Current guidelines are technical and less practical in the Asia-Pacific region, and there are still massive challenges in timely diagnosis and managing these disorders effectively. Therefore, a Malaysian joint societies\' task force has developed a consensus on disorders of EGJ outflow based on the latest evidence, while taking into consideration the practical relevance of local and regional context and resources. Twenty-one statements were established after a series of meetings and extensive review of literatures. The Delphi method was used in the consensus voting process. This consensus focuses on the definition, diagnostic investigations, the aims of treatment outcome, non-surgical or surgical treatment options, management of treatment failure or relapse, and the management of complications. This consensus advocates the use of high-resolution esophageal manometry for diagnosis of disorders of EGJ outflow. Myotomy, via either endoscopy or laparoscopy, is the preferred treatment option, while pneumatic dilatation can serve as a secondary option. Evaluation and management of complications including post-procedural reflux and cancer surveillance are recommended.
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  • 文章类型: Journal Article
    饮食调整是促进吞咽困难患者吞咽安全性的常见补偿策略。国际吞咽困难饮食标准化倡议(IDDSI)指南提供了对质地改性食品和增稠液体的定性描述。本研究旨在基于常见的中国食材和菜肴,建立不同IDDSI水平的定量质地和流变学数据。使用质地轮廓分析(TPA)和粘度计获得了226种食品质地样品和93种液体稠度样品的质地和流变特性,分别。这种定量数据的建立可用于未来质地改性食品的开发和研究目的。
    Diet modification is a common compensation strategy to promote swallowing safety in patients with swallowing difficulties. The International Dysphagia Diet Standardisation Initiative (IDDSI) guideline provides qualitative descriptions on texture-modified food and thickened liquid. This study aimed to establish quantitative textural and rheological data on different IDDSI levels based on common Chinese ingredients and dishes. Textural and rheological properties of 226 samples of various food textures and 93 samples of various liquid consistencies were obtained using a texture profile analysis (TPA) and viscometer, respectively. The establishment of such quantitative data can be used for future texture-modified food product development and research purposes.
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  • 文章类型: Journal Article
    目的:就头颈癌(HNC)患者吞咽困难的管理制定专家共识声明(ECS),以解决争议并提供质量改进的机会。HNC的吞咽困难被定义为患有鼻腔癌症的患者的吞咽障碍,鼻旁窦,鼻咽部,口腔,口咽,喉部,或者下咽.
    方法:具有吞咽困难专业知识的开发小组成员遵循既定的ECS开发指南。一位专业的搜索策略师系统地回顾了文献,并利用现有的最佳证据来撰写针对治疗成人HNC人群吞咽困难的提供者的共识声明.开发小组优先考虑了存在重大实践差异的主题,以及如果可能达成共识,将提高HNC患者护理质量的主题。
    结果:开发小组确定了60个候选共识声明,根据最初提出的75个主题和问题,重点解决以下高收益主题:(1)风险因素,(2)筛选,(3)评价,(4)预防,(5)干预措施,(六)监督。在德尔菲调查的两次迭代和重复语句的删除之后,48项声明符合共识的标准化定义;12项声明被指定为无共识。
    结论:就48项与风险因素有关的陈述达成了专家共识,筛选,评估,预防,干预,和HNC患者吞咽困难的监测。临床医生可以使用这些声明来提高护理质量,告知政策和协议,欣赏没有共识的领域。未来的研究,理想的随机对照试验,有必要解决与HNC患者吞咽困难相关的其他争议。
    To develop an expert consensus statement (ECS) on the management of dysphagia in head and neck cancer (HNC) patients to address controversies and offer opportunities for quality improvement. Dysphagia in HNC was defined as swallowing impairment in patients with cancers of the nasal cavity, paranasal sinuses, nasopharynx, oral cavity, oropharynx, larynx, or hypopharynx.
    Development group members with expertise in dysphagia followed established guidelines for developing ECS. A professional search strategist systematically reviewed the literature, and the best available evidence was used to compose consensus statements targeted at providers managing dysphagia in adult HNC populations. The development group prioritized topics where there was significant practice variation and topics that would improve the quality of HNC patient care if consensus were possible.
    The development group identified 60 candidate consensus statements, based on 75 initial proposed topics and questions, that focused on addressing the following high yield topics: (1) risk factors, (2) screening, (3) evaluation, (4) prevention, (5) interventions, and (6) surveillance. After 2 iterations of the Delphi survey and the removal of duplicative statements, 48 statements met the standardized definition for consensus; 12 statements were designated as no consensus.
    Expert consensus was achieved for 48 statements pertaining to risk factors, screening, evaluation, prevention, intervention, and surveillance for dysphagia in HNC patients. Clinicians can use these statements to improve quality of care, inform policy and protocols, and appreciate areas where there is no consensus. Future research, ideally randomized controlled trials, is warranted to address additional controversies related to dysphagia in HNC patients.
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  • 文章类型: Journal Article
    目的:由于小儿神经肌肉疾病(pNMD)中吞咽困难和构音障碍的患病率很高,因此言语语言病理学(SLP)被认为是必不可少的干预措施。pNMD中SLP的循证指南缺失,儿童可能得不到最好的照顾。本研究旨在达成共识,并就pNMD中的SLP干预提出最佳实践建议。方法:与一组经验丰富的荷兰语语言病理学家一起使用改良的Delphi技术。在两轮在线调查和面对面共识会议中,SLP专家提出了四种类型pNMD病例的干预项目(先天性肌病,杜氏肌营养不良症,强直性肌营养不良1型和脊髓性肌萎缩2型),包括吞咽困难的症状,构音障碍,流口水,和口腔卫生问题。他们对协议的级别进行了评级。结果:达成共识的干预项目被纳入最佳实践建议。这些建议涵盖了六个核心干预组成部分(等等,解释和建议,培训和治疗,辅助和调整,转介其他学科,和监测)适用于所述症状。结论:深入了解治疗方案对于促进语言病理学家的临床决策至关重要。当前的研究为pNMD领域的语言病理学家提供了最佳实践建议。
    UNASSIGNED: Speech-language pathology (SLP) is considered an essential intervention due to the high prevalence of dysphagia and dysarthria in paediatric neuromuscular disorders (pNMD). Evidence-based guidelines for SLP in pNMD are missing and children could be deprived the best of care. This study aimed to achieve consensus and present best practice recommendations on SLP intervention in pNMD.
    UNASSIGNED: A modified Delphi technique was used with a panel of experienced Dutch speech-language pathologists. In two online survey rounds and a face-to-face consensus meeting, the SLP experts proposed intervention items for cases of four types of pNMD (congenital myopathy, Duchenne muscular dystrophy, myotonic dystrophy type 1, and spinal muscular atrophy type 2), covering symptoms of dysphagia, dysarthria, drooling, and oral hygiene problems. They rated the level of agreement.
    UNASSIGNED: Intervention items that achieved consensus were incorporated into best practice recommendations. These recommendations cover six core intervention components (wait and see, explanation and advice, training and treatment, aids and adjustments, referral to other disciplines, and monitoring) suitable for the described symptoms.
    UNASSIGNED: Insight into treatment options is essential to facilitate speech-language pathologists in clinical decision-making. The current study led to best practice recommendations for speech-language pathologists working within the field of pNMD.
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  • 文章类型: Review
    目的:制定一套循证策略,以帮助老年人改善吞咽功能并防止并发症造成的进一步损害。
    方法:两轮德尔菲调查。
    方法:根据7名研究人员的文献综述,初步制定了一套针对老年人的吞咽困难治疗策略,包括74项相关项目。21名小组成员进行了一项在线调查,采用改进的德尔菲法收集和分析专家意见的数据。
    结果:两轮专家咨询的正系数分别为85.71%和83.33%,分别。达成共识,包括53个项目,并分配到以下五个部分:(1)筛选,(2)评估,(3)培训,(4)干预措施和(5)管理。这些策略以每个部分的首字母缩写命名-“SATIA”。该管理策略可用于指导老年人吞咽困难的管理。
    To develop a set of evidence-informed strategies to assist older people to improve swallowing functions and prevent further damage from complications.
    A two-round Delphi survey.
    An initial set of dysphagia care strategies with 74 relevant items for older people was formed based on a literature review by seven researchers. An online survey was conducted by 21 panellists, and data of experts\' opinions were collected and analysed by improved Delphi method.
    The positive coefficients in the two rounds of expert consultation were 85.71% and 83.33%, respectively. Consensus was reached with 53 items included and was allocated into the following five sections: (1) screening, (2) assessment, (3) training, (4) interventions and (5) management. These strategies were named with the acronym of each section-\"SATIA\". The management strategy can be applied to guide the management of older people with dysphagia.
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  • 文章类型: Journal Article
    嗜酸性粒细胞性食管炎(EoE)是儿童和成人吞咽困难的日益常见的原因,以及最常见的食管疾病之一,对身体健康和生活质量有重大影响。我们为儿科和成人胃肠病学家提供了关于EoE评估和管理的当前最佳实践的单一综合指南。
    临床标准服务委员会委托英国胃肠病学会的食道部门制定这些指南。指南发展小组包括成人和儿科胃肠病学家,外科医生,营养师,变态反应学家,病理学家和患者代表。人口,干预,比较和结果过程用于生成问题,以对证据进行系统审查。已发布的证据已审核并更新至2021年6月。建议的分级,评估,使用开发和评估(GRADE)系统来评估证据并提出建议。举行了两轮投票,评估协议的达成程度和建议的力度,接受需要80%的共识。
    关于EoE演示文稿的57项声明,诊断,调查,产生了管理和并发症,并就未来研究的领域发表了进一步的声明。
    这些英国胃肠病学会和英国儿科胃肠病学会的综合成人和儿科指南,肝病学和营养学基于多学科医疗保健专业人员小组的证据和专家共识,包括患者倡导者和患者支持团体,帮助临床医生管理EoE患者及其并发症。
    Eosinophilic oesophagitis (EoE) is an increasingly common cause of dysphagia in both children and adults, as well as one of the most prevalent oesophageal diseases with a significant impact on physical health and quality of life. We have provided a single comprehensive guideline for both paediatric and adult gastroenterologists on current best practice for the evaluation and management of EoE.
    The Oesophageal Section of the British Society of Gastroenterology was commissioned by the Clinical Standards Service Committee to develop these guidelines. The Guideline Development Group included adult and paediatric gastroenterologists, surgeons, dietitians, allergists, pathologists and patient representatives. The Population, Intervention, Comparator and Outcomes process was used to generate questions for a systematic review of the evidence. Published evidence was reviewed and updated to June 2021. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system was used to assess the evidence and make recommendations. Two rounds of voting were held to assess the level of agreement and the strength of recommendations, with 80% consensus required for acceptance.
    Fifty-seven statements on EoE presentation, diagnosis, investigation, management and complications were produced with further statements created on areas for future research.
    These comprehensive adult and paediatric guidelines of the British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition are based on evidence and expert consensus from a multidisciplinary group of healthcare professionals, including patient advocates and patient support groups, to help clinicians with the management patients with EoE and its complications.
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  • 文章类型: Journal Article
    食品增稠剂通常用于制备用于治疗吞咽困难的增稠液体。已知用商业食品增稠剂制备的增稠液体的国家吞咽困难饮食(NDD)厚度水平根据增稠剂类型而变化。增稠剂的推荐量,增稠剂品牌,和准备说明。特别是,制造商必须提供详细的准备说明,以达到正确的厚度水平。然而,制造商提供的产品标签上的流变信息通常不准确。这里,根据制造商的指南,通过混合商业黄原胶(XG)基增稠剂来制备各种布丁粘稠液体,并对其流变特性进行了表征。在韩国销售的四种不同的基于XG的增稠剂(A-D)制备的几种增稠液体不符合基于NDD指南的类似布丁的标准(>1,750mPa·s)。流变参数值的显著差异(ηa,50,n,和G\')也在各种增稠液体中被发现。只有一种在韩国制造的增稠剂(增稠剂A)显示出最佳结果,与其他增稠剂相比,它满足了各种食品液体的布丁稠度粘度范围,并且还显示出较低的粘性和增强的丸剂形成能力,可轻松安全地吞咽(B,C,andD).
    Food thickeners are commonly used to prepare thickened liquids for the management of dysphagia. The National Dysphagia Diet (NDD) thickness levels of thickened liquids prepared with commercial food thickeners are known to vary depending on the thickener type, recommended amount of thickener, thickener brand, and preparation instructions. Particularly, detailed preparation instructions must be provided by the manufacturers to achieve the correct thickness levels. However, the rheological information on product labels provided by manufacturers is typically not accurate. Here, various pudding-thick liquids were prepared by mixing commercial xanthan gum (XG)-based thickeners based on the manufacturers\' guidelines, and their rheological properties were characterized. Several thickened liquids prepared with four different XG-based thickeners (A-D) marketed in Korea did not meet the pudding-like criterion (> 1,750 mPa·s) based on the NDD guidelines. Significant differences in rheological parameter values (ηa,50, n, and G\') were also identified among the various thickened liquids. Only one thickener (thickener A) manufactured in Korea showed optimal results, which satisfied the pudding-thick viscosity range for various food liquids and also showed lower stickiness and enhanced bolus formation ability for easy and safe swallowing when compared to other thickeners (B, C, and D).
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  • 文章类型: Journal Article
    超声(US)具有评估吞咽和喉功能的新兴证据基础。可访问性和技术进步支持使用US作为临床评估工具;然而,没有足够的证据支持将其转化为临床实践。这项研究旨在就将US转化为临床实践以评估吞咽和喉功能的优先事项达成共识。名义组技术(NGT)被用作共识发展的正式方法。临床医生和学者,美国国际工作组的所有成员,被邀请参加这项研究。举行了两次NGT会议,参与者默默地产生然后分享想法。参与者匿名对项目进行排名。在参与者按优先级顺序对项目进行重新排名之前,先汇总排名。关于排名的讨论被记录和转录以告知分析。与参与者的成员核对告知了最终分析。参与者(n=15)是言语和语言病理学家,代表六个国家的物理治疗师和超声医师。确定了15个项目,并优先考虑1-13(包括两个同等排名的项目)。可靠性,有效性和规范性数据成为研究的关键领域,而培训方案的制定和与利益相关者的互动被认为对美国的实践至关重要。分析揭示了可能在研究中共同解决的共同主题,除了排名的优先级。将US转化为临床实践的方法将使该工具的有效实施成为可能。优先级可能会随着临床和专业环境的转变而发展,但这项研究为推进该领域的研究和临床实践提供了框架。
    Ultrasound (US) has an emerging evidence base for the assessment of swallowing and laryngeal function. Accessibility and technological advances support the use of US as a clinical assessment tool; however, there is insufficient evidence to support its translation into clinical practice. This study aimed to establish consensus on the priorities for translation of US into clinical practice for the assessment of swallowing and laryngeal function. Nominal Group Technique (NGT) was used as a formal method of consensus development. Clinicians and academics, all members of an international US working group, were invited to participate in the study. Two NGT meetings were held, where participants silently generated and then shared ideas. Participants anonymously ranked items. Rankings were aggregated before participants re-ranked items in order of priority. Discussions regarding rankings were recorded and transcribed to inform analysis. Member-checking with participants informed the final analysis. Participants (n = 15) were speech and language pathologists, physiotherapists and sonographers representing six countries. Fifteen items were identified and prioritised 1-13 (including two equally ranked items). Reliability, validity and normative data emerged as key areas for research while development of training protocols and engagement with stakeholders were considered vital to progressing US into practice. Analysis revealed common themes that might be addressed together in research, in addition to the ranked priority. A measured approach to the translation of US into clinical practice will enable effective implementation of this tool. Priorities may evolve as clinical and professional contexts shift, but this study provides a framework to advance research and clinical practice in this field.
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