背景:被忽视的热带病(NTD)是主要影响边缘化人群的慢性传染病。可用于治疗NTD的化学治疗库有限且过时,这对控制和根除这些疾病构成了挑战。制药行业对开发新的治疗替代方案缺乏资金的兴趣加剧了这种情况。此外,在NTD治疗中使用的相当多的药物具有低水溶性。为了解决这个问题,溶解度增强策略,例如可以使用与环糊精(CD)的包合复合物。
目标:因此,本系统综述旨在介绍CD在与用于治疗一些全球最普遍的NTD的药物和化疗化合物复合中的应用,以及这些复合物如何增强这些疾病的治疗.
方法:两个书目数据库,科学直接和PubMed,被用来进行搜索。研究的选择和系统评价的撰写遵循了PRISMA指南概述的标准。
结果:在总共978篇文章中,在应用排除标准后选择23例。所有选择的研究与使用CD作为增加NTD中使用的治疗剂的溶解度的策略一致。
结论:结果表明,CD可以增强治疗被忽视热带病(NTD)的化学治疗剂的溶解度。这篇综述提供的数据清楚地突出了CD在开发被忽视的热带病新疗法中的潜在用途。它可以帮助制定更有效和更安全的未来治疗方法。
BACKGROUND: Neglected Tropical Diseases (NTD) are chronic infectious conditions that primarily affect marginalized populations. The chemotherapeutic arsenal available for treating NTD is limited and outdated, which poses a challenge in controlling and eradicating these diseases. This is exacerbated by the pharmaceutical industry\'s lack of interest in funding the development of new therapeutic alternatives. In addition, a considerable number of drugs used in NTD therapy have low aqueous solubility. To address this issue, solubility enhancement strategies, such as the use of inclusion complexes with cyclodextrins (CD) can be employed.
OBJECTIVE: Therefore, this systematic review aims to present the application of CD in complexing with drugs and chemotherapeutic compounds used in the therapy of some of the most prevalent NTD worldwide and how these complexes can enhance the treatment of these diseases.
METHODS: Two bibliographic databases, Science Direct and PubMed, were used to conduct the search. The selection of studies and the writing of this systematic review followed the criteria outlined by the PRISMA guidelines.
RESULTS: From a total of 978 articles, 23 were selected after applying the exclusion criteria. All the studies selected were consistent with the use of CD as a strategy to increase the solubility of therapeutic agents used in NTD.
CONCLUSIONS: The results indicate that CD can enhance the solubility of chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTD). This review presents data that clearly highlights the potential use of CD in the development of new treatments for neglected tropical diseases. It can assist in the formulation of future treatments that are more effective and safer.