已知环氧乙烷(EO)会引起炎症损伤,据报道,适当的体育锻炼会影响肾结石的风险。在这项研究中,我们的目的是调查EO与肾结石之间的关系,以及体育锻炼是否可能影响EO与肾结石之间的关系。总的来说,包括3336名成人参与者;其中,330人(9.9%)有自我报告的肾结石病史。数据来自2013-2016年全国健康和营养检查调查。体力活动是用代谢当量计算的,每周频率,和持续时间。使用Logistic回归和有限三次样条(RCS)曲线来探索身体活动之间的关联。EO,和肾结石。RCS的剂量反应曲线显示EO和肾结石之间呈非线性正相关。多变量逻辑回归分析显示,与最低四分位数(Q1)组相比,最高四分位数(Q4)组的参与者患肾结石风险的校正比值比(aOR)为1.548(95%置信区间1.123-2.135,P=0.008)。此外,与Q1组相比,在没有体力活动的参与者中,Q4组肾结石风险的aOR为1.326,低体力活动参与者的风险降低(aOR1.239),高体力活动者的风险增加(aOR1.981)。这项研究表明,EO是肾结石的危险因素,适当的体力活动可能在一定程度上缓和这种关系;然而,过度的体力活动会加剧这种关系。
Ethylene oxide (EO) is known to cause inflammatory damage, and suitable physical activity can reportedly affect the risk of kidney stones. In this
study, we aimed to investigate the relationship between EO and kidney stones and whether physical activity can potentially influence the relationship between EO and kidney stones. Overall, 3,336 adult participants were included; of them, 330 (9.9%) had a self-reported history of kidney stones. Data were obtained from the National Health and Nutrition Examination Survey 2013-2016. Physical activity was calculated using metabolic equivalent, weekly frequency, and duration. Logistic regression and restricted cubic spline (RCS) curves were used to explore the association between physical activity, EO, and kidney stones. Dose-response curves from the RCS showed a nonlinear positive association between EO and kidney stones. Multivariate logistic regression analysis revealed an adjusted odds ratio (aOR) of 1.548 (95% confidence interval 1.123-2.135, P = 0.008) for the risk of kidney stones among participants in the highest quartile (Q4) group compared with those in the lowest quartile (Q1) group. Furthermore, compared to the Q1 group, the aOR for risk of kidney stones in the Q4 group was 1.326 in participants without physical activity, a decreased risk (aOR 1.239) in participants with low physical activity, and an increased risk (aOR 1.981) in those with high physical activity. This
study suggests that EO is a risk factor for kidney stones and that suitable physical activity may moderate this relationship to some extent; however, excessive physical activity can exacerbate this relationship.