背景:一品红是被子植物的主要属之一,它广泛分布在世界各地,包括亚洲,非洲和中美洲和南美洲。大猩猩的根或块茎以药用而闻名,尤其是在中国。他们中的许多人,比如一品红,大猩猩和大猩猩KansuiS.L.LiouexS.B.Ho..被用作中草药。
目的:本文综述了从一品红属植物中分离的二萜类化合物及其药理活性,以评估其传统用途和潜在的未来发展。
方法:从科学期刊上收集了大品红属的研究信息,通过图书馆和电子数据搜索的书籍和报告(Scifinder,WebofScience,PubMed,Elsevier,Scopus,谷歌学者,Springer,科学直接,威利,ACS,CNKI和KewPlantsoftheWordOnline)。同时,它也是从发表的材料医学作品中获得的,民间记录,人物学文献,博士和硕士学位论文。
结果:被称为大品红属的主要成分,二萜具有许多药理特性,如抗炎,抗病毒活性和细胞毒性。迄今为止,从该属中鉴定出各种类型的二萜类化合物,包括异imarane,Rosane,abietane,ent-kaurane,ent-atisane.cembrane,卡班,lathyrane,Myrsinane,jatropholane,Tigliane,ingenane,jatrophane,paraliane,pepluane,和euphoractin.
结论:这篇综述描述了2012年至2021年从45种一品红中分离出的14种类型的二萜,总共615种化合物。其中,主要包括jatrophane(171),lathyrane(92),Myrsinane(62),abietane(70),ent-atisane(36),ent-kaurane(7),替吉兰(26)和吉兰(19)。推测了这些化合物可能的生物学途径。同时,总结了这些化合物的10多个生物活性,如抗炎,抗病毒活性和细胞毒性。
BACKGROUND: Euphorbia is one of the major genera in angiosperms, which is widely distributed all over the world, including Asia, Africa and Central and South America. The roots or tubers of Euphorbia are famous for medicinal purposes, especially in China. Many of them, such as Euphorbia pekinensis Rupr, Euphorbia fischeriana Steud and Euphorbia Kansui S.L.Liou ex S.B.Ho. . are used as Chinese herbal medicines.
OBJECTIVE: This paper reviews the diterpenoids isolated from the genus Euphorbia species and the pharmacological activities of these compounds to evaluate its traditional use and potential future development.
METHODS: Information on the studies of the genus Euphorbia Linn was collected from scientific journals, books and reports via library and electronic data search (Scifinder, Web of Science, PubMed, Elsevier, Scopus, Google Scholar, Springer, Science Direct, Wiley, ACS, CNKI and Kew Plants of the Word Online). Meanwhile, it was also obtained from published works of material medica, folk records, ethnophmacological literatures, Ph.D. and Masters dissertations.
RESULTS: Known as the main constituents of the genus Euphorbia Linn, Diterpenoids possess many pharmacological properties such as anti-inflammation, antiviral activities and cytotoxicity. To date, various types of diterpenoids were identified from this genus, including isopimarane, rosane, abietane, ent-kaurane, ent-atisane. cembrane, casbane, lathyrane, myrsinane, jatropholane, tigliane, ingenane, jatrophane, paraliane, pepluane, and euphoractin.
CONCLUSIONS: This
review describes 14 types of
diterpenoid isolated from 45 Euphorbia species from 2012 to 2021, a total of 615 compounds. Among them, mainly include jatrophane (171), lathyrane (92), myrsinane (62), abietane (70), ent-atisane (36), ent-kaurane (7), tigliane (26) and ingenane (19). The possible biological pathways of these compounds were presumed. At the same time, more than 10 biological activities of these compounds were summarized, such as anti-inflammation, antiviral activities and cytotoxicity.