背景:丝虫病,由Dirofilariaspp引起的疾病。,特别是犬科动物的Dirofilariaimmitis和Dirofilariarepens,经常发生在犬科动物和猫科动物中,偶尔在人类中,在温带,全球亚热带和热带地区。虽然非常有效,在过去的三十年中,安全,方便的预防药物已用于治疗丝虫病,这种疾病仍然是流行地区的主要兽医和公共卫生问题。昆虫媒介,寄主与寄生虫的关系及其相互作用。在中国很少受到关注,而且关于该国动物和人类中丝虫病患病率的英语信息很少。本系统综述和荟萃分析的目的是根据可用的英文和中文文献评估中国犬种丝虫病的状况。
方法:我们系统地检索了5个关于中国犬源丝虫病流行情况的流行病学研究数据库,最终选择了42个符合纳入系统评价和荟萃分析的研究。使用Rv4.2.1中meta包中的随机效应模型进行荟萃分析。
结果:随机效应模型在过去100年中,中国犬类的混合加权患病率为13.8%(2896/51,313,95%置信区间8.2-20.4%),具有高度异质性(I2=99.5%)。
结论:我们的分析表明,中国犬类丝虫病的患病率逐渐下降,但是Dirofilariaspp的范围。扩大了。老年和户外犬的阳性感染率较高。结果表明,应更加重视宿主因素,以有效控制和管理该病。
BACKGROUND: Dirofilariasis, the disease caused by Dirofilaria spp., and in particular by Dirofilaria immitis and Dirofilaria repens in canines, occurs frequently in canids and felids, and occasionally in humans, in temperate, sub-tropical and tropical regions globally. Although highly effective, safe and convenient preventive medicines have been available for the treatment of dirofilariasis for the past three decades, the disease remains a major veterinary and public health concern in endemic areas. The insect vectors, host-parasite relationships and interactions of Dirofilaria spp. have received little attention in China, and there is very little information in English regarding the prevalence of dirofilariasis in animals and humans in the country. The aim of this systematic
review and meta-analysis is to evaluate the status of canine dirofilariasis in China based on the available literature in English and in Chinese.
METHODS: We systematically searched five databases for epidemiologic studies on the prevalence of canine dirofilariasis in China and finally selected 42 studies eligible for inclusion in the systematic
review and meta-analysis. The meta-analysis was performed using the random effects model in the meta package in R v4.2.1.
RESULTS: The random effects model gave a pooled and weighted prevalence of Dirofilaria infection among dogs in China in the past 100 years of 13.8% (2896/51,313, 95% confidence interval 8.2-20.4%) with a high level of heterogeneity (I2 = 99.5%).
CONCLUSIONS: Our analyses indicated that the prevalence of canine dirofilariasis in China has gradually declined, but that the range of Dirofilaria spp. has expanded. Older and outdoor dogs presented a higher rate of positive infection. The findings indicated that more attention should be paid to host factors for the effective control and management of this disease.