Detector

检测器
  • 文章类型: Journal Article
    放射性物质污染食物和水是一个严重的健康问题。有几种检测和测量放射性物质的方法,其中一些是近年来开发的。本文旨在探讨食品和水中放射性物质的检测和测量方法。讨论了每种方法的原理和优缺点。结果表明,其中一些方法,如光谱法γ射线高纯度锗,便携式氡气体测量师SILENA,RAD7和电感耦合等离子体质谱法,具有更高的检测和测量灵敏度。能谱γ射线高纯锗法因其能够以高分辨率测量宽范围的放射性核素而比其他方法受到更多关注。
    Contamination of food and water with radioactive substances is a serious health problem. There are several methods to detect and measure radioactive materials, some of which have been developed in recent years. This paper aims to discuss the methods of detecting and measuring radioactive substances in food and water. The principles and the advantages and disadvantages of each method have been discussed. The results showed that some of these methods, such as spectrometry γ-ray high-purity germanium, portable radon gas surveyor SILENA, RAD7, and inductively coupled plasma mass spectrometry, have a higher sensitivity for detection and measurement. The spectrometry γ-ray high-purity germanium method has attracted more attention than other methods because it can measure a wide range of radionuclides with high resolution.
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  • 文章类型: Journal Article
    高效液相色谱(HPLC)是分离和测定具有复杂性质的新药的最有用的技术之一。HPLC检测器的选择取决于分子的化学性质,潜在的杂质,样本的矩阵,灵敏度,可用性,和/或检测器的成本。使用UV/Vis检测器的HPLC方法是制药应用中最常用且简单的分析程序,但它仅限于具有发色团的化合物。因此,这篇综述概述了弱发色团化合物分析方法的发展。这篇综述描述了PubMed中有关基于HPLC的方法的精选论文,Scopus,语义学者和科学直接数据库,基本上在2006年至2023年之间。在分析研究中,UV-Vis的HPLC方法,FLD,CAD,ELSD,RID,ECD,发现了CLND和MS检测。这项研究是对科学文献中描述的不同类型的检测的比较,通常用于具有弱发色团的化合物。预计本综述将有助于分析开发领域的科学家改进与候选药物相关的研究,并根据监管水平确保其质量。
    High-performance liquid chromatography (HPLC) is one of the most useful techniques for the separation and determination of new drugs with a complex nature. The selection of an HPLC detector depends on the chemical nature of molecules, potential impurities, matrix of the sample, sensitivity, availability, and/or cost of the detector. HPLC methods with UV/Vis detectors are the most used and simple analytical procedures in pharmaceutical applications, but it is limited to compounds that possess a chromophore. Hence, this review provides an overview on the development of analytical methods for compounds with weak chromophores. The review described selected papers about HPLC based methods in the PubMed, Scopus, Semantic Scholar and ScienceDirect databases, basically between 2006 and 2023. Of the analytical studies, the HPLC methods with UV-Vis, FLD, CAD, ELSD, RID, ECD, CLND and MS detection were found. This study is a comparison of different types of detection that are described in scientific literature and are routinely used for compounds with weak chromophores. It is expected that this review will be helpful for scientists in the analytical development fields to improve research related to the drug candidates and to ensure its quality according to regulatory levels.
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  • 文章类型: Journal Article
    具有不同化学键特征的碳纳米材料-石墨烯(sp2)和纳米金刚石(sp3)-是一类新型全碳混合纳米材料的建筑用砖,其中两个具有sp3和sp2杂化的不同碳网络共存,相互作用,甚至相互转化。由两个边界纳米同素异形体的独特电子能带结构定义的非凡的物理化学性质确保了这些全碳纳米材料的巨大应用潜力和多功能性。综述了sp2-sp3纳米材料的研究现状,包括石墨烯/氧化石墨烯-纳米金刚石复合材料和杂化物,石墨烯/氧化石墨烯-金刚石异质结,和其他用于传感的sp2-sp3纳米碳混合物,电子,和其他紧急应用程序。还讨论了新型sp2-sp3过渡纳米碳相和结构。此外,从纳米尺度的SP2(石墨烯)到SP3(金刚石表面和纳米金刚石)的双向转变,对于创新制造至关重要,在广泛的理论基础上讨论了稳定性和化学反应性评估,计算和实验研究。
    Carbon nanomaterials with a different character of the chemical bond-graphene (sp2) and nanodiamond (sp3)-are the building bricks for a new class of all-carbon hybrid nanomaterials, where the two different carbon networks with sp3 and sp2 hybridization coexist, interacting and even transforming into one another. The extraordinary physiochemical properties defined by the unique electronic band structure of the two border nanoallotropes ensure the immense application potential and versatility of these all-carbon nanomaterials. The review summarizes the status quo of sp2 - sp3 nanomaterials, including graphene/graphene-oxide-nanodiamond composites and hybrids, graphene/graphene-oxide-diamond heterojunctions, and other sp2-sp3 nanocarbon hybrids for sensing, electronic, and other emergent applications. Novel sp2-sp3 transitional nanocarbon phases and architectures are also discussed. Furthermore, the two-way sp2 (graphene) to sp3 (diamond surface and nanodiamond) transformations at the nanoscale, essential for innovative fabrication, and stability and chemical reactivity assessment are discussed based on extensive theoretical, computational and experimental studies.
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