与其他成瘾物质相比,大麻成瘾患者的数量明显超过那些报告依赖他人的患者,更容易上瘾的物质。不幸的是,大多数大麻成瘾未经治疗,在那些选择治疗的人中,对青少年和年轻人的要求要高得多。
研究大麻素依赖性在遗传背景下的关系-DRD2基因的rs1799732多态性与心理特征和焦虑之间的关联。
研究组由515名男性志愿者组成。其中,214例患者被诊断为大麻成瘾,301例未成瘾。患者被诊断为NEO五因素人格量表(NEO-FFI),和状态特质焦虑量表(STAI)问卷。使用实时PCR方法在一组大麻成瘾患者和非成瘾对照中研究了DRD2rs1799732基因的人格特质与多态性之间的相互作用。
与对照组相比,病例组在STAI状态上获得了明显更高的分数,STAI特征,神经质和开放量表,以及外向性得分较低,宜人,和尽责的尺度。成瘾者与对照组基因型频率无统计学差异,但是在DRD2等位基因rs179973的频率上,成瘾者和对照组之间存在统计学上的显着差异。多变量方差分析显示,DRD2rs1799732基因型对NEO-FFI一致性量表有统计学意义的影响,对大麻素成瘾或其不存在对NEO-FFI一致性量表评分有统计学意义的影响。
研究同质亚组——就像我们的研究一样——似乎是合理的,特别是当与遗传决定因素和心理特征相结合时。在多基因和多因素实体中,这样的战略是有前途的。
Compared to other addictive substances, patients with cannabis addiction are significantly outnumbered by those who report dependence on other, more addictive substances. Unfortunately, most cannabis addiction goes untreated, and among those who choose treatment, the requirements are much higher for adolescents and young adults.
To examine the relationship of cannabinoid dependency in the genetic context-the association between the rs1799732 polymorphism of the DRD2 gene and psychological traits and anxiety.
The study group consisted of 515 male volunteers. Of these, 214 patients were diagnosed with cannabis addiction and 301 were non-addicted. Patients were diagnosed with NEO Five-Factor Personality Inventory (NEO-FFI), and State-Trait Anxiety Inventory (STAI) questionnaires. The interactions between personality traits and polymorphisms in the DRD2 rs1799732 gene were investigated in a group of cannabis-addicted patients and non-addicted controls using the real-time PCR method.
Compared to the control group, the case group obtained significantly higher scores on the STAI State, STAI Trait, Neuroticism and Openness scales, as well as lower scores on the Extraversion, Agreeableness, and Conscientiousness scales. There was no statistically significant difference between addicts and the control group in the frequency of genotypes, but there was a statistically significant difference between addicts and the control group in the frequency of the DRD2 allele rs179973. The multivariate ANOVA analysis showed a statistically significant influence of the DRD2 rs1799732 genotype on the NEO-FFI agreeableness scale and a statistically significant effect of addiction to cannabinoids or its absence on the NEO-FFI agreeableness scale score.
Studying homogeneous subgroups-as in our study-seems reasonable, particularly when combined with genetic determinants and psychological traits. In multigenic and multifactorial entities, such a strategy has a future.